Results 91 to 100 of about 346,542 (364)
Irreversible evolution, obstacles in fitness landscapes and persistent drug resistance [PDF]
arXiv, 2023 We use fitness graphs, or directed cube graphs, for analyzing evolutionary reversibility. The main application is antimicrobial drug resistance. Reversible drug resistance has been observed both clinically and experimentally. If drug resistance depends on a single point mutation, then a possible scenario is that the mutation reverts back to the wild ...
arxiv
Microbial Communities of the Providence River [PDF]
, 2015 The Providence River has been industrialized for over one-hundred years. Industries such as oil storage and metal recycling facilities have left high levels of pollutant metals, including lead (Pb), in the soil and water.
Kratch, Jacqueline
core +1 more source
Compounding Effects of Climate Warming and Antibiotic Resistance. [PDF]
, 2020 Bacteria have evolved diverse mechanisms to survive environments with antibiotics. Temperature is both a key factor that affects the survival of bacteria in the presence of antibiotics and an environmental trait that is drastically increasing due to ...
Cruz-Loya, Mauricio +4 more
core +1 more source
New strategies for surface modification of cotton and silk textiles with antimicrobial properties [PDF]
, 2014 Throughout the past decades hospitals have been facing a major challenge concerning the growing multi-drug microbial resistance, especially in immunodepressed patients.
Gouveia, Isabel C. +3 more
core +1 more source
Advanced Healthcare Materials, EarlyView.A hollow‐structured Fe3O4@AgAu@PDA‐ZnPc nanosphere has been developed, exhibiting controllable catalytic activity and “photothermal‐photodynamic‐Ag+” coupling antibacterial characteristics. When subjected to a rotating magnetic field, these performances are uniquely enhanced by magnetic propulsion, allowing the nanosphere to function as a magnetic ...
Jing Wang +7 more
wiley +1 more source
A Model for Emergence of Multiple Anti-Microbial Resistance in a Petri Torus [PDF]
arXiv, 2017 This work introduces a new statistical physics lattice model of bacteria interacting with anti-microbial drugs that can reproduce qualitative features of resistance emergence and whose model parameters and outputs can be measured with controlled \textit{in vitro} experiments. The lattice is inhabited by agents modeled by Ising perceptrons.
arxiv
Evolving generalists via dynamic sculpting of rugged landscapes [PDF]
, 2019 Evolving systems, be it an antibody repertoire in the face of mutating pathogens or a microbial population exposed to varied antibiotics, constantly search for adaptive solutions in time-varying fitness landscapes. Generalists correspond to genotypes that remain fit across diverse selective pressures; cross-reactive antibodies are much wanted but rare,
arxiv +1 more source
Advanced Healthcare Materials, EarlyView.This perspective provides an overview of the growing interest in utilizing various gasotransmitters—small gaseous signaling molecules namely nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S)—for several therapeutic applications, with emphasis on the potential use of porous materials as carriers to provide safe and controlled local ...
Rosana V. Pinto +2 more
wiley +1 more source
Graph2MDA: a multi-modal variational graph embedding model for predicting microbe-drug associations [PDF]
arXiv, 2021 Accumulated clinical studies show that microbes living in humans interact closely with human hosts, and get involved in modulating drug efficacy and drug toxicity. Microbes have become novel targets for the development of antibacterial agents. Therefore, screening of microbe-drug associations can benefit greatly drug research and development.
arxiv
Microbial drug resistance and the roles of the new antibiotics.
Cleveland Clinic Journal of Medicine, 2001 Physicians should be cautious in prescribing broad-spectrum antibiotics, particularly vancomycin and the fluoroquinolones, because widespread use of these drugs is promoting antibiotic resistance. Resistance is now found in many organisms, including staphylococci, enterococci, streptococci, pneumococci, and Pseudomonas aeruginosa.
openaire +3 more sources