Results 101 to 110 of about 346,542 (364)

Promising approaches to optimize the biological properties of the antimicrobial peptide esculentin-1a(1-21)NH2. amino acids substitution and conjugation to nanoparticles [PDF]

, 2017
Antimicrobial peptides (AMPs) represent an interesting class of molecules with expanding biological properties which make them a viable alternative for the development of future antibiotic drugs.
Cacciafesta, Mauro, Cappiello, Floriana, Casciaro, Bruno, Mangoni, Maria Luisa   +3 more
core   +2 more sources

Short‐Chain Fatty Acids Modulate Anti‐ROR1 CAR T‐Cell Function and Exhaustion in an Intestinal Adenocarcinoma‐on‐Chip Model

Advanced Healthcare Materials, EarlyView.
Short‐chain fatty acids modulate anti‐ROR1 chimeric antigen receptor (CAR) T‐cell function in an intestinal adenocarcinoma‐on‐chip model. Butyrate and propionate reduce cytotoxicity, cytokine release, and infiltration by inducing a regulatory T‐cell phenotype and T‐cell exhaustion via histone deacetylase inhibition.
Valentin D. Wegner, Adrian Feile, Miriam Alb, Michael Hudecek, Philip Hewitt, Alexander S. Mosig   +5 more
wiley   +1 more source

Microbial extracellular vesicles contribute to antimicrobial resistance.

PLoS Pathogens
With the escalating global antimicrobial resistance crisis, there is an urgent need for innovative strategies against drug-resistant microbes. Accumulating evidence indicates microbial extracellular vesicles (EVs) contribute to antimicrobial resistance ...
Bowei Jiang, Yi Lai, Wenhao Xiao, Tianyu Zhong, Fengping Liu, Junjie Gong, Junyun Huang   +6 more
doaj   +1 more source

GCGACNN: A Graph Neural Network and Random Forest for Predicting Microbe–Drug Associations

Biomolecules
The interaction between microbes and drugs encompasses the sourcing of pharmaceutical compounds, microbial drug degradation, the development of drug resistance genes, and the impact of microbial communities on host drug metabolism and immune modulation ...
Shujuan Su, Meiling Liu, Jiyun Zhou, Jingfeng Zhang   +3 more
doaj   +1 more source

Tri‐Layered Bioactive Cutaneous Scaffold with Integrated Bioactive Metal Organic Frameworks to Promote Full‐Thickness Infected Diabetic Wound Healing: Multifaceted Therapeutic Strategies

Advanced Healthcare Materials, EarlyView.
The limitations of existing clinical treatments highlight the need for a more comprehensive strategy for addressing infected diabetic wounds. A tri‐layered scaffold is developed to deliver therapeutics loaded in CuBDC and ZIF‐8 MOFs that are tailored to the requirements of deep‐infected diabetic wounds.
Ayse Gunyakti Mujtaba, Ayşe Karakeçili, Berna Topuz, Barış Batur, Okan Onar, Mehmet Eray Elçiğir, Çağdaş Oto, Alireza Hanifehnezhad, Kaan Orhan   +8 more
wiley   +1 more source

Detection of Multi-drug Resistant \u3cem\u3eEscherichia coli\u3c/em\u3e in the Urban Waterways of Milwaukee, WI [PDF]

, 2015
Urban waterways represent a natural reservoir of antibiotic resistance which may provide a source of transferable genetic elements to human commensal bacteria and pathogens. The objective of this study was to evaluate antibiotic resistance of Escherichia
Ahuja, Neha H., DeNies, Maxwell S., Hristova, Krassimira R., Kappell, Anthony D., Ledeboer, Nathan A., Newton, Ryan J.   +5 more
core   +1 more source

Designing for Degradation: Transient Devices Enabled by (Nano)Cellulose

Advanced Materials, EarlyView.
Recent progress in transient devices enabled by (nano)cellulosic materials is reviewed. Transiency mechanisms, advantages of nanocelluloses, and a suite of applications are discussed. A circular thinking approach coupled with life cycle assessment is applied to critically revisit the potential, advantages, and challenges of nanocellulose‐enabled ...
Lucas J. Andrew, Erlantz Lizundia, Mark J. MacLachlan   +2 more
wiley   +1 more source

"DRUG RESISTANCE PATTERN IN ISOLATED BACTERIA FROM BLOOD CULTURES" [PDF]

Acta Medica Iranica, 2004
Bacteremia is an important infectious disease which may lead to death. Common bacteria and pattern of antibiotic resistance in different communities are different and understanding these differences is important.
A. Sobhani, H. Shodjai S. Javanbakht
doaj   +2 more sources

An Environmental Science and Engineering Framework for Combating Antimicrobial Resistance [PDF]

, 2018
On June 20, 2017, members of the environmental engineering and science (EES) community convened at the Association of Environmental Engineering and Science Professors (AEESP) Biennial Conference for a workshop on antimicrobial resistance.
Alcalde, Reinaldo E., Alvarez, Pedro J.J., Ashbolt, Nicholas, Bischel, Heather, Capiro, Natalie L., Crossette, Emily, Frigon, Dominic, Grimes, Kassandra, Haas, Charles N., Ikuma, Kaoru, Kappell, Anthony D., Kimbell, Lee K., LaPara, Timothy M., Li, Mengyan, Li, Xu, McNamara, Patrick J., Navab-Daneshmand, Tala, Pruden, Amy, Raskin, Lutgarde, Riquelme, Maria Virginia, Seo, Youngwoo, Sobsey, Mark D., Sozzi, Emanuele, Vikesland, Peter, Wigginton, Krista, Zhou, Zhi   +25 more
core   +1 more source

Elucidation of the RamA Regulon in Klebsiella pneumoniae Reveals a Role in LPS Regulation [PDF]

, 2014
Klebsiella pneumoniae is a significant human pathogen, in part due to high rates of multidrug resistance. RamA is an intrinsic regulator in K. pneumoniae established to be important for the bacterial response to antimicrobial challenge; however, little ...
Bengoechea, J, De Majumdar, S, Elborn, JS, Fanning, S, Finn, S, Fookes, M, Gally, DL, Ingram, RJ, Kissenpfennig, A, Llobet, E, McAteer, SP, Monahan, A, Schneiders, T, Spence, S, Yu, J   +14 more
core   +1 more source