Results 141 to 150 of about 195,207 (265)

Protein Lactylation in Cancer: Mechanisms and Therapeutic Targets. [PDF]

MedComm (2020)
Ouyang Q, Hu Q, Wang C, He Y, Zeng R, Li Y, Su C, Lu G, Zhu X, Xiao L, Zhou H.   +10 more
europepmc   +1 more source

Extracellular Vesicles in Autoimmune Diseases: From Diagnostic Biomarkers to Engineered Therapeutics

Advanced Science, EarlyView.
This review provides a systematic comparison of extracellular vesicles (EVs) from both mammalian and plant sources in the context of autoimmune diseases. It highlights their emerging roles as precision biomarkers and engineered therapeutic platforms.
Yufei Wu, Huiyuan Ma, Tinghui Zhu, Shuwei Huang, Manxi Lu, Qiong Wang, Zai‐Long Chi   +6 more
wiley   +1 more source

Editorial: Pseudomonas and Acinetobacter: From Drug Resistance to Pathogenesis

Frontiers in Cellular and Infection Microbiology, 2018
Ghassan M. Matar
doaj   +1 more source

Structure-Based Screening of Deep-Sea Microbial Metabolites Against <i>Plasmodium falciparum</i> Dihydroorotate Dehydrogenase. [PDF]

Biology (Basel)
Singh A, Rengasamy KRR, Benjakul S.
europepmc   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Metagenomic and metatranscriptomic profiling of bronchoalveolar lavage fluid identifies microbial and host biomarkers of drug-resistant tuberculosis. [PDF]

Front Cell Infect Microbiol
Zhang H, Zhang L, Yang B, Gao C, Liu H, Zhang Y, Chen X.   +6 more
europepmc   +1 more source

Therapeutic Gases in Biomedicine: Updates on Nitric Oxide and Beyond

Advanced Science, EarlyView.
Therapeutic gases, including NO, CO, H2S, H2, CO2, O2, and Xe, play vital roles in cellular signaling and repair. This review highlights the emerging carriers and delivery systems that enable controlled, localized gas release for diagnostic and therapeutic applications.
Syed Muntazir Andrabi, Navatha Shree Sharma, Imran Ibn Gani Rather, S. M. Shatil Shahriar, Jingwei Xie   +4 more
wiley   +1 more source

Age- and diet-driven assembly of the gut antibiotic resistome in humans and food-producing animals. [PDF]

Gut Microbes
Zhang T, Wang J, Feng Q, Xu X, Zhu W, Mao S, Liu J.   +6 more
europepmc   +1 more source

TrxR2 Lactylation Facilitates Mitochondrial Protection and Endothelial Ferroptosis Resistance in Diabetic Cardiomyopathy

Advanced Science, EarlyView.
TrxR2 deletion in diabetic mice suppresses TUFM‐AMPK‐FUNDC1‐dependent mitophagy in endothelial cells, resulting in SCP2 upregulation and mitochondrial translocation of ACSL4. Mitochondrial ACSL4 promotes mitochondrial eicosanoid biosynthesis and ferroptosis, thereby aggravating cardiac microvascular injury and diabetic cardiomyopathy.
Su Li, Muyin Liu, Chao Chen, Xinyan Li, Xiaopei Yan, Wentao Zhu, Wenyan Qiu, Qiyu Li, Xiangyu Sun, Chao Huang, Ming Yin, Zhangwei Chen, Yao Lu, Junbo Ge, Xiangqing Kong, Juying Qian, Yuqiong Chen   +16 more
wiley   +1 more source

Microbiome-driven resistance in cervical cancer therapy: from mechanistic dissection to clinical translation. [PDF]

Expert Rev Mol Med
Wu X, Wang D, Mao X, Dong B, Wang Y.
europepmc   +1 more source