Results 141 to 150 of about 4,488,653 (302)

Oral Prebiotic Polysaccharide Hydrogels Sustaining Colon Antibody Release Alleviate Inflammatory Bowel Disease

Advanced Science, EarlyView.
An orally administered prebiotic polysaccharide hydrogel (predaGel) based on inulin and alginate‐dopamine is stable in the stomach, adheres to the intestine, and degrades slowly in the colon. It enables site‐specific delivery of anti‐TNF‐α and anti‐IL‐12/23 antibodies, scavenges reactive oxygen species, and remodels gut microbiota, offering effective ...
Xinyi Dong, Huan He, Li Cao, Fenghua Meng, Zhiyuan Zhong   +4 more
wiley   +1 more source

The importance of sample size in the determination of a flock-level antimicrobial resistance profile for Escherichia coli in broilers

, 2011
Determining herd- or flock-specific antimicrobial resistance profiles is important to guide therapeutic use of antimicrobials and to assess risk factors for the development and spread of antimicrobial resistance.
A. Smet, Jeroen Dewulf, P. Butaye, Boudewijn Catry, An Martel, Persoons, Davy, M. Heyndrickx, Annemieke Smet, Dewulf, Jeroen, Bollaerts, Kaatje, F. Haesebrouck, Persoons, DavyUGent001999096238802000105019975254989144F899BE38-F0ED-11E1-A9DE-61C894A0A6B4, Heyndrickx, MarcDI058010005656870000-0002-2913-26862DFF7EC8-F0EE-11E1-A9DE-61C894A0A6B4, Martel, AnDI058010014327280000-0001-7609-5649F5F50C8C-F0ED-11E1-A9DE-61C894A0A6B4, A. Martel, Lieve Herman, Martel, An, J. Dewulf, Catry, Boudewijn, Patrick Butaye, Marc Heyndrickx, K. Bollaerts, Butaye, Patrick, Davy Persoons, B. Catry, Haesebrouck, Freddy, Heyndrickx, Marc, L. Herman, Freddy Haesebrouck, D. Persoons, Herman, Lieve, Dewulf, JeroenCA05DI080019920941518010012560070000-0001-9843-5990F57DE986-F0ED-11E1-A9DE-61C894A0A6B4, Smet, AnnemiekeUGent0020001015038020001010769776015886900000-0001-9852-9137F897F832-F0ED-11E1-A9DE-61C894A0A6B4, Smet, Annemieke, Kaatje Bollaerts, Butaye, PatrickDI05801001126570F5276C1E-F0ED-11E1-A9DE-61C894A0A6B4, Haesebrouck, FreddyDI058010005165810000-0002-1709-933XF4151B78-F0ED-11E1-A9DE-61C894A0A6B4   +36 more
core   +1 more source

Microalgae Hybrid Biosystem for Enhanced Oral Delivery of Rifaximin in Hepatic Encephalopathy Treatment

Advanced Science, EarlyView.
The microalgae‐nanoparticle hybrid system with antibacterial activity can improve the oral delivery and therapeutic efficiency for hepatic encephalopathy treatment. Oral administration of the system can reduced systemic ammonia levels, enhanced intestinal barrier function, attenuated systemic and neuroinflammation, ameliorated cognitive impairments ...
Kaiyue Wang, Xueting Huang, Lingxiao Yang, Jin Liu, Lei Lei, Shaomin Zou, Kai Wang, Min Zhou, Zhe Tang   +8 more
wiley   +1 more source

An exploration of the ocular mysteries linking nanoparticles to the patho-therapeutic effects against keratitis

Journal of Nanobiotechnology
Microbial keratitis, a sight-threatening corneal infection, remains a significant global health concern. Conventional therapies using antimicrobial agents often suffers from limitations such as poor drug penetration, side effects, and occurrence of drug ...
Siying Qu, Shuihua Zheng, Sibtain Muhammad, Liang Huang, Bing Guo   +4 more
doaj   +1 more source

Hygiene: microbial strategies to reduce pathogens and drug resistance in clinical settings

Microbial Biotechnology, 2017
Summary Healthcare‐associated infections ( HAI s) are a global concern, affecting all western hospitals, and profoundly impairing the clinical outcome of up to 15% of all hospitalized patients.
openaire   +2 more sources

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Microbial spectrum and drug-resistance profile of isolates causing bloodstream infections in febrile cancer patients at a referral hospital in Addis Ababa, Ethiopia

Infection and Drug Resistance, 2018
Balew Arega,1,2 Yimtubezinash Woldeamanuel,2 Kelemework Adane,3 Abdulaziz A Sherif,4 Daniel Asrat2 1College of Health Sciences, Debre Markos University, Debre Markos, 2Department of Microbiology, Immunology, and Parasitology, School of Medicine, College ...
Arega B, Woldeamanuel Y, Adane K, Sherif AA, Asrat D   +4 more
doaj  

Intermittent Fasting Restores Cardiac Lipid Homeostasis in Diabetic Cardiomyopathy in Association With Akkermansia Muciniphila and 1‐methyl‐L‐histidine

Advanced Science, EarlyView.
Intermittent fasting reshapes the gut microbiota in diabetic cardiomyopathy, restoring Akkermansia muciniphila and the microbiota‐associated metabolite 1‐methyl‐L‐histidine. This shift is linked to improved cardiac lipid homeostasis, reduced lipid peroxidation, and attenuated myocardial injury, highlighting a gut microbiota–metabolite–lipid axis in ...
Kaiyuan Jiang, Fen Xiong, Yiwen Peng, Lingfei Meng, Xinran Wang, Yingruo Xu, Tian Tang, Hongchang Gao   +7 more
wiley   +1 more source

Prevalence of Over-the-counter use of Antibiotics among Patients visiting Outpatient Department of a Primary Health Centre: An Observational Study

Journal of Nepal Medical Association
Introduction: Antimicrobials are the most commonly used medicine. Over-the-counter use of antibiotics is more prevalent in developing countries, contributing to inappropriate use and increasing antimicrobial resistance.
Shova Sapkota, Kiran Shrestha, Parikshit Prasai, Mausam Thapa Magar, Ojaswee Karki   +4 more
doaj   +1 more source

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source