Advanced Science, EarlyView.BLP‐trained macrophages show augmented resistance to infection, but their mechanisms remain unclear. scRNA‐seq identified 13 BMDM subsets, with two novel anti‐inflammatory/antibacterial subpopulations (C5/C7) emerging post‐BLP training. BLP training activates NRF2, attenuates oxidative stress/ferroptosis, and boosts glycolysis/OXPHOS. Adoptive transfer
Yantong Wan +13 more
wiley +1 more source
Recent advances in understanding microbial regulation of host multi-drug resistance transporters
, 2021 Sage E. Foley +2 more
openalex +1 more source
Advanced Science, EarlyView.Single‐cell RNA sequencing revealed that MIF signaling drives inflammatory fibroblastmyeloid cell crosstalk in atopic dermatitis. Cinobufagin, a potent PDE4D inhibitor, suppresses MIF and reduces inflammation by restoring the cAMP/PKA/CREB pathway. Genetic knockout validates PDE4D as a key driver and promising therapeutic target for atopic dermatitis ...
Shicong Li +14 more
wiley +1 more source
Effect of AcrAB Efflux Pump on Ciprofloxacin Resistance Rate in Escherichia coli Isolates
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2018 Background and Objectives: One of the important mechanisms of resistance to fluoroquinolones in Escherichia coli, is AcrAB efflux pumps activity. In this study, the frequency of acrA and acrB genes and the effect of efflux pumps on the ciprofloxacin ...
Alisha Akya +2 more
doaj
Exploring Drug Resistance: Microbial Profiles, Antibiotic Sensitivity, and Biofilm Development in Orthopedic Implant Infections [PDF]
Kristi Sarkar +2 more
openalex +1 more source
Geraniol, a Potential Alternative to Antibiotics for Bovine Mastitis Treatment Without Disturbing the Host Microbial Community, Does Not Lead to Drug Residues or Induce Drug Resistance [PDF]
, 2021 Wei Guo +13 more
openalex +1 more source
Advanced Science, EarlyView.Mobile messenger RNAs (mRNAs) can travel long distances, serving as systemic signals that participate in plant growth and stress acclimation. This work determines that PHR proteins mediate the Pi starvation response (PSR)‐specific long‐distance transport of mRNAs and that these PSR‐specific mobile mRNAs represent noncoding transcripts in recipient ...
Weiguo Dong +9 more
wiley +1 more source
Advanced Science, EarlyView.This study explores how iron and manganese oxides transform sewage sludge into plant biostimulants during composting. Non‐targeted identification reveals the main species of plant biostimulants. Metagenomic analysis reveals that 2‐line ferrihydrite specifically enriches microbial genes for biosynthesis, boosting plant‐growth promoters.
Yu Zhang +7 more
wiley +1 more source
Non-canonical Metatranscriptomic analysis of COVID-19 and Dengue reveals an expanded microbial and AMR landscape in COVID-19 mortality patients. [PDF]
PLoS PathogYadav A +9 more
europepmc +1 more source
Hyperelastic Starch Hydrogel Configures Edible and Biodegradable All‐Components for Soft Robots
Advanced Science, EarlyView.Hyperelastic starch hydrogel is tailored via a phase separation strategy of solvent‐antisolvent co‐modulation. The mechanical performance of starch hydrogel is widely tuned with maximum strains: 194.4–361.4%; maximum tensile stresses: 34–192 kPa; and Young's moduli: 36.0–205.8 kPa. Notably, the hydrogel achieves complete soil degradation within 24 days
Siyu Yao +7 more
wiley +1 more source