Results 61 to 70 of about 4,488,653 (302)

Transferable drug resistance plasmids in fish-pathogenic bacteria [PDF]

, 2000
Chemotherapeutic agents have been developed for treating bacterial infections and have been widely used for cultured fish for the last 30 years in Japan.
Aoki, Takashi
core   +1 more source

The challenge of developing robust drugs to overcome resistance

, 2011
Drug resistance is problematic in microbial disease, viral disease and cancer. Understanding at the outset that resistance will impact the effectiveness of any new drug that is developed for these disease categories is imperative.
Schiffer, Celia A., Pollastri, Michael P., Amy C. Anderson, Peet, Norton P., Norton P. Peet, Anderson, Amy C., Celia A. Schiffer, Michael P. Pollastri   +7 more
core   +1 more source

Epigenetics as a mechanism driving polygenic clinical drug resistance [PDF]

, 2006
Aberrant methylation of CpG islands located at or near gene promoters is associated with inactivation of gene expression during tumour development.
Glasspool, R.M., Teodoridis, JM, Glasspool, RM, Teodoridis, J.M., Brown, R, R M Glasspool, Brown, R., J M Teodoridis, R Brown   +8 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

_M. tuberculosis_ interactome analysis unravels potential pathways to drug resistance [PDF]

, 2008
Drug resistance is a major problem for combating tuberculosis. Lack of understanding of how resistance emerges in bacteria upon drug treatment limits our ability to counter resistance.
Nagasuma Chandra, Karthik Raman
core  

Drug resistance mutations in drug-naive HIV type 1 subtype C-infected individuals from rural Malawi. [PDF]

, 2010
In this preliminary study we show that in 2008, 3 years after antiretroviral therapy was introduced into the Karonga District, Malawi, a greater than expected number of drug-naive individuals have been infected with HIV-1 subtype C virus harboring major ...
Grace P. McCormack, Emmanuel Banda, Judith R. Glynn, Bansode, Vijay, McCormack, Grace P., Glynn, Judith R., Neil French, French, Neil, Glynn, Judith R, Zuzanna J. Drebert, Banda, Emmanuel, Drebert, Zuzanna J., Molesworth, Anna, Vijay Bansode, Travers, Simon AA, Amelia Crampin, Drebert, Zuzanna, McCormack, Grace P, Crampin, Amelia, Anna Molesworth, Drebert, Zuzanna J, Simon A.A. Travers, Travers, Simon A A, Travers, Simon A.A., Ngwira, Bagrey, Bagrey Ngwira   +25 more
core   +1 more source

Current Research on HIV Drug Resistance [PDF]

, 2022
HIV drug resistance is an unavoidable challenge for HIV/AIDS professionals, and it has long been a major obstacle hindering the global effort to contain HIV/AIDS.

core   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

Molecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen, Zhi Zhao, Henrik Horndalsveen, Maria Moksnes Bjaanæs, Bjørn Henning Grønberg, Tarje Halvorsen, Tesfaye Madebo, Marianne Aanerud, Jussi Koivunen, Kersti Oselin, Saulius Cicenas, Nina Helbekkmo, Jarkko Ahvonen, Maria Silvoniemi, Tine Norman Alver, Tonje Dalen, Åsa Kristina Öjlert, Saima Jamil Farooqi, Åslaug Helland, Vilde Drageset Haakensen   +19 more
wiley   +1 more source

New Delhi metallo-beta-lactamase-1-producing Acinetobacter spp. infection: report of a survivor

Revista da Sociedade Brasileira de Medicina Tropical, 2016
: New Delhi metallo-beta-lactamase-1 (NDM-1) is a bacterial enzyme that renders the bacteria resistant to a variety of beta-lactam antibiotics. A 20-year-old man was hospitalized several times for surgical treatment and complications caused by a right ...
Fabiana Schuelter-Trevisol, Graciane Jacinta Schmitt, Jane Martins de Araújo, Liliane Braga de Souza, Juliana Gomes Nazário, Raquel Landuchi Januário, Rogério Sobroza de Mello, Daisson José Trevisol   +7 more
doaj   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source