Results 81 to 90 of about 876,917 (302)

Artificial intelligence‐driven anticancer peptide discovery

iMetaOmics
Cancer has become a major global health threat. Despite advances in modern medicine, current therapeutic strategies still face many limitations. Anticancer peptides (ACPs), due to their high selectivity, low toxicity, and multitarget effects, have ...
Junrui Wu, Shuaiqi Ji, Kashif Iqbal Sahibzada, Mengxue Lou, Feiyu An, Wenqian Li, Jiawei Guo, Taowei Zhang, Xinyi Zhang, Yilin Chou, Henan Zhang, Hao Jin, Teng Ma, Weichi Liu, Begali Alikulov, Natalia Alekseevna Golovneva, Hooi Ling Foo, Issayeva Kuralay, Zhihong Sun, Dongqing Wei, Rina Wu   +20 more
doaj   +1 more source

Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection

Advanced Science, EarlyView.
Dual LILRB1/B2 blockade with mac20G10 reshapes myeloid activation during acute SIV infection by targeting LILRB1 and LILRB2 on myeloid cells. This treatment enhances CD80 expression on selected myeloid subsets and increases plasma IFN‐λ, IL‐8, and IL‐1RA.
Florian Meurisse, Sixtine Coindre, Anne Wijkhuisen, Romain Marlin, Laure Fournier Le Ray, Juliette Pons, Melyssa Yaugel‐Novoa, Véronique Avettand‐Fenoel, Laurent Abi‐Rached, Anne‐Sophie Gallouet, Francis Relouzat, Mael Gourves, Asier Saez‐Cirion, Hisashi Arase, Gerard Zurawski, Sandra Zurawski, Nathalie Dereuddre‐Bosquet, Roger Le Grand, Stéphanie Simon, Olivier Lambotte, Benoit Favier   +20 more
wiley   +1 more source

Beyond antibiotics: probiotics as a promising ally against Helicobacter pylori

Frontiers in Pharmacology
Helicobacter pylori (H. pylori) is considered a key causative agent of gastritis, peptic ulcer, and gastric cancer, affecting more than half of the world’s population.
Lin Yuan, Lin Yuan, Chong Yang, Chong Yang, Ying Han, Ying Han, Fan Yang, Fan Yang, Huabing Tu, Huabing Tu   +9 more
doaj   +1 more source

Valorization of Fruit Pomace by Enzymatic Treatment and Microbial Fermentation

Fruit pomace is a major processing byproduct abundant in fermentable sugars, dietary fibers, and phenolic and other bioactive compounds. This review provides a summary of the latest developments in fruit pomace enzymatic valorization and microbial ...
Clinton E. Okonkwo, Ali H. Al-Marzouqi, Mutamed Ayyash, Oni Yuliarti, Afaf Kamal-Eldin, Nadiya Samad   +5 more
core   +1 more source

Macromolecular excipients exert biological effects via their microbial fermentation absorbable products. [PDF]

, 2016
Fermentation of these macromolecular food or pharmaceutical excipient ingredients by the gut microbiota leads to the formation of short chain fatty acids (SCFA) which can be absorbed from the gut into the general circulation.
Shireesh Apte
core  

Phylogenetic analysis of microbial communities in different regions of the gastrointestinal tract in Panaque nigrolineatus, a wood-eating fish [PDF]

, 2012
The Neotropical detritivorous catfish Panaque nigrolineatus imbibes large quantities of wood as part of its diet. Due to the interest in cellulose, hemi-cellulose and lignin degradation pathways, this organism provides an interesting model system for the
McDonald, R., Watts, Joy, Joy E. M. Watts (124946), Schreier, H., Ryan McDonald, Joy E M Watts, Ryan McDonald (74014), Harold J. Schreier (124940), Harold J Schreier   +8 more
core   +2 more sources

Targeted β‐Glucan‐Veiled Oral Apremilast Nanotherapy Modulates Key Dysbiosis‐Associated Gut Microbiota and Alleviates Ulcerative Colitis‐Associated Anxiety, Depression, and Neuropsychiatric Behaviors

Advanced Science, EarlyView.
This study introduces β‐glucan‐shielded apremilast laden nanomicelles that withstand gastrointestinal degradation, selectively accumulate in inflamed colon tissue, and modulate the microbiota–gut–brain axis. The formulation restores barrier integrity, reduces systemic and neuroinflammation, and improves anxiety‐ and depression‐like behaviors in colitis
Chandrashekhar Jori, Ahmed Shaney Rehman, Taruna Lamba, Anas Ahmad, Jattin Kumar, Aneesh Ali, Ajesh Joshi, Ashraf Ali, Suhel Parvez, Javed N. Agrewala, Rehan Khan   +10 more
wiley   +1 more source

Bactericidal and cell membrane disruption potential of protein extract from buttermilk-derived probiotic Pediococcus pentosaceus OBK05 against Salmonella typhimurium ATCC 14028

Frontiers in Microbiology
IntroductionFoodborne Salmonellosis remains a significant global health challenge, and the rise of antimicrobial resistance is limiting the efficacy of traditional antibiotic treatments, emphasising the need to develop natural biopreservatives to improve
Priyadarshini Boda, Mohammad Saddam Hussain, Bhima Bhukya   +2 more
doaj   +1 more source

Chemical Composition and Antioxidant Characteristic of Traditional and Industrial Zhenjiang Aromatic Vinegars during the Aging Process

Molecules, 2018
Zhenjiang aromatic vinegar (ZAV) is one of the well-known fermented condiments in China, which is produced by solid-state fermentation. It can be classified into traditional Zhenjiang aromatic vinegar (TZAV) and industrial Zhenjiang aromatic vinegar ...
Chaoya Zhao, Ting Xia, Peng Du, Wenhui Duan, Bo Zhang, Jin Zhang, Shenghu Zhu, Yu Zheng, Min Wang, Yongjian Yu   +9 more
doaj   +1 more source

Probiotic‐Derived Vesicles Rectally Delivered via Thermo‐Gelling Copolymer Promote Mucosal Healing and Reduce Inflammation in Ulcerative Colitis

Advanced Science, EarlyView.
A thermo‐responsive rectal delivery platform integrating probiotic‐derived extracellular vesicles within a hyaluronic acid‐based copolymer enables localized and sustained therapy for ulcerative colitis. The formulation effectively suppresses inflammation, promotes macrophage polarization toward a regenerative phenotype, restores epithelial barrier ...
Ayushi Mairal, Ubaid Tariq, Shreya Mehrotra, Saravanan Matheshwaran, Jan Marsal, Ashok Kumar   +5 more
wiley   +1 more source