Results 151 to 160 of about 862,177 (279)

Role of MalQ Enzyme in a Reconstructed Maltose/Maltodextrin Pathway in Actinoplanes sp. SE50/110

Microorganisms
The pseudotetrasaccharide acarbose, produced by Actinoplanes sp. SE50/110, is a relevant secondary metabolite used in diabetes type II medication.
Camilla März, Sophia Nölting, Lars Wollenschläger, Alfred Pühler, Jörn Kalinowski   +4 more
doaj   +1 more source

Single-cell genomics of microbial dark matter

, 2018
Single-cell genomics allows bypassing the culturing step and to directly access environmental microbes one cell at a time. The method has been successfully applied to explore archaeal and bacterial candidate phyla, referred to as microbial dark matter ...
Rinke, Christian, Christian Rinke
core   +1 more source

Rainfall Shapes the Diversity of Soil Nitrogen‐Fixing Microorganisms Worldwide

Advanced Science, EarlyView.
This study reveals the distinctive pattern and mechanism of rainfall driving the global biodiversity and biogeography of soil potential N‐fixing microorganisms, and constructs the theoretical framework. The results guide us on how to maintain ecosystem productivity under future climate changes (e.g., whether a specific region needs more N fertilizers ...
Bin Hua, Shuang Pang, Ang Li, Zonghao Hu, Honghui Wu, Shuhan Zhang, Yi Fan, Yi Wu, Wei Yang, Yachao Zhao, Yupeng Guan, Baoming Ji, Deliang Kong, Yong Zhao, Anton A. Goncharov, Anastasia Yu. Korotkevich, Rong Mao, Yang Zhang, Ximei Zhang   +18 more
wiley   +1 more source

Strain sharing and persistence of microbial pathogens colonizing the skin of residents in a regional nursing home network

Nature Communications
Antimicrobial resistance (AMR) is a health threat disproportionately affecting nursing home (NH) residents. Surveillance and infection control in NHs are restricted to nares or perirectal cultures, overlooking skin colonization and multidrug-resistant ...
Yaovi M. G. Hounmanou, Gabrielle M. Gussin, Sean Conlan, Raveena D. Singh, Clay Deming, Diana M. Proctor, Marco Teixeira, Ashlee M. Earl, Colin J. Worby, Heidi H. Kong, Susan S. Huang, Julia A. Segre   +11 more
doaj   +1 more source

6. Genomics and the microbial world

, 2018
Together, molecular biology and genomics have made it possible to explore the diversity and ecology of the 99 per cent of microbes that cannot be cultured in laboratories.
John Archibald
core   +1 more source

Highly Sensitive Spatial Host‐Microbiome Transcriptomics in FFPE Tissues via Iterative Hydrogel Expansion

Advanced Science, EarlyView.
Ex‐spRandom is a spatial transcriptomics platform that synergizes random‐primed chemistry with iterative hydrogel expansion. By physically decrowding the dense FFPE matrix, this scalable technology shatters the traditional resolution‐sensitivity barrier.
Shunji Zhang, Mengyuan Wang, Jiaye Chen, Yuyi Zhu, Bin Zhu, Ziye Xu, Yuan Liao, Yongcheng Wang   +7 more
wiley   +1 more source

ROS‐Responsive Eye Drop for Controlled Release of 20‐Deoxyingenol Improves Diabetic Corneal Healing by Activating Macrophage Autophagy and Metabolic Reprogramming

Advanced Science, EarlyView.
Schematic illustration of ROS‐responsive TSPBA‐PVA microspheres loaded with 20‐deoxyingenol (TP/20‐DOI) for diabetic corneal wound healing: (a) fabrication and ROS‐triggered release; (b) autophagy activation and metabolic reprogramming in macrophages; (c) suppression of macrophage‐derived CXCL3/CXCL5, attenuation of neutrophil infiltration, and ...
Jiaxin Wu, Wanying Chen, Haijiang Qiu, Weihan Zheng, Ying Jiao, Jingheng Du, Zhudan Zhuang, Xing Hua, Jingyi Gu, Yuheng Liu, Zhaojin Li, Jingbin Xie, Hanxiao Sun, Huifei Lan, Xin Sun, Yunxia Xue, Ting Fu, Zhijie Li, Guobing Chen, Shiyu Li, Jun Liu   +20 more
wiley   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

From Microbial Genomics to Metagenomics. [PDF]

Int J Genomics, 2020
Kant R, Kumar A, Sironen T.
europepmc   +1 more source

Programming Gut Microbiome Function Through Cross‐Feeding: From Ecological Mechanisms to Live Biotherapeutics

Advanced Science, EarlyView.
This graphical abstract presents gut microbial cross‐feeding through a Mechanism–Technology–Application framework. It summarizes major resource‐transfer modes, the experimental and computational tools used to establish causality, and potential interventions involving dietary substrates, live biotherapeutic products, and engineered microbes.
Chuankai Sun, Teng Ma, Hao Jin, Zelong Li, Yi Cheng, Jingjin Li, Lai‐Yu Kwok, Zhihong Sun   +7 more
wiley   +1 more source