Results 61 to 70 of about 3,415,645 (289)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Quantification and identification of bacterial presence in salted eggs

Current Biomedicine
Objective This study aimed to quantify the total bacterial count in salted eggs and identify bacterial species that may affect their quality. Methods Fifty samples consisted of 10 fresh salted eggs that passed the candling test, 10 portions of pasta ...
Zukhrufa Vista Vindriati, Usamah Afiff, Trioso Purnawarman   +2 more
doaj   +1 more source

Identification and Biological Activity of Microbial Metabolites of Xanthohumol

Chemical and Pharmaceutical Bulletin, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Herath, Wimal, Ferreira, Daneel, Khan, Shabana Iqrar, Khan, Ikhlas Ahmad   +3 more
openaire   +3 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Isolation, identification and conservation of bacteria of biotechnological interest

One Health & Risk Management, 2023
Introduction. The evaluation of microbial biodiversity is an important step in the process of its conservation, and the identification of bacterial strains of biotechnological interest allows their application as support for the development of ...
Ludmila BALAN, Valerina SLANINA, Nina BOGDAN-GOLUBI   +2 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

From microbial fuel cell (MFC) to microbial electrochemical snorkel (MES): maximizing chemical oxygen demand (COD) removal from wastewater [PDF]

, 2011
The paper introduces the concept of the microbial electrochemical snorkel (MES), a simplified design of a “short-circuited” microbial fuel cell (MFC). The MES cannot provide current but it is optimized for wastewater treatment.
Benjamin Erable, Erable, Benjamin, Luc Etcheverry, Bergel, Alain, Alain Bergel, Etcheverry, Luc   +5 more
core   +1 more source

BacT-Seq, a Nanopore-Based Whole-Genome Sequencing Workflow Prototype for Rapid and Accurate Pathogen Identification and Resistance Prediction from Positive Blood Cultures: A Feasibility Study

Diagnostics
Background/Objectives: Rapid and accurate pathogen identification and antimicrobial susceptibility testing (AST) are critical for the proper management of patients with bloodstream infection (BSI).
Meriem El Azami, Véronique Lanet, Corinne Beaulieu, Aurélien Griffon, Stéphane Schicklin, Pierre Mahé, Marion Darnaud, Marion Helsmoortel, Erwin Sentausa, Adrien Saliou, Mallory Poncelet, Raphaël Fleury, Marine Ibranosyan, François Vandenesch, Emmanuelle Santiago-Allexant   +14 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Proteomic applications in microbial identification [PDF]

Microbiology Australia, 2011
Proteomics-based approaches have been used in microbial taxonomy for the last several decades. Recent improvements in instruments and software have led to the appearance of mass spectrometric fingerprinting and peptide survey approaches allowing for highly rapid and accurate taxonomic diagnoses suitable for high-throughput laboratories as well as means
openaire   +1 more source