Results 191 to 200 of about 588,081 (304)

Codevelopment of gut microbial metabolism and visual neural circuitry over human infancy. [PDF]

mBio
Bonham KS, Margolis ET, Fahur Bottino G, Sobrino AC, Patel F, McCann S, Zieff MR, Miles M, Herr D, Davel L, Bosco C, Khula South African Data Collection Team, Huttenhower C, Pini N, Alexander DC, Jones DK, Williams SCR, Amso D, Gladstone M, Fifer WP, Donald KA, Gabard-Durnam LJ, Klepac-Ceraj V.   +22 more
europepmc   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Development and Application of an LC-MS/MS Method for Simultaneous Quantification of Azathioprine and Its Metabolites: Pharmacokinetic and Microbial Metabolism Study of a Colon-Targeted Nanoparticle. [PDF]

Pharmaceuticals (Basel)
Zhang J, Han J, Sun N, Zhu Y, Mei D, Zhao L.   +5 more
europepmc   +1 more source

New microbial metabolism [PDF]

Nature, 2011
openaire   +1 more source

Rapid Proteome‐Wide Discovery of Protein–Protein Interactions With ppIRIS

Advanced Science, EarlyView.
ppIRIS is a lightweight deep learning framework for proteome‐wide protein–protein interaction prediction directly from sequence. By fusing evolutionary and structural embeddings with a regularized Siamese architecture, ppIRIS achieves state‐of‐the‐art accuracy across species, enables minute‐scale screening, and reveals biologically validated bacterial ...
Luiz Felipe Piochi, Di Tang, Johan Malmström, Yasaman Karami, Hamed Khakzad   +4 more
wiley   +1 more source

Microbial metabolism mediates the deteriorative effects of sedentary behaviour on insulin resistance. [PDF]

Clin Transl Med
Ju J, He J, Ye B, Li S, Zhao J, Chen W, Zhang Q, Zhao W, Yang J, Liu L, Li Y, Xia M, Liu Y.   +12 more
europepmc   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Engrafting gut bacteriophages have potential to modulate microbial metabolism in fecal microbiota transplantation. [PDF]

Microbiome
Ji S, Ahmad F, Peng B, Yang Y, Su M, Zhao X, Vatanen T.   +6 more
europepmc   +1 more source

Bacterial Outer Membrane Vesicles in Potentiating Cancer Vaccines: Progress and Prospects

Advanced Science, EarlyView.
Bacterial outer membrane vesicles (OMVs) have emerged as versatile platforms for cancer vaccine development owing to their intrinsic immunostimulatory properties and high engineering flexibility. This review summarizes OMV biology, immune mechanisms, and engineering strategies that enhance vaccine efficacy, discusses key translational challenges, and ...
Jiabeini Zhang, Tianyu Shao, Fengjiang Qu, Caiyun Bai, Sijie Li, Pin Gao, Wenna Li, Keman Cheng, Xiao Zhao, Zhimin Fan   +9 more
wiley   +1 more source

Microbial metabolism in laboratory reared marine snow as revealed by a multi-omics approach. [PDF]

Microbiome
Hou L, Zhao Z, Steger-Mähnert B, Jiao N, Herndl GJ, Zhang Y.   +5 more
europepmc   +1 more source