Results 181 to 190 of about 2,028,087 (333)

Neuro‐Cancer Interactions Shape Glioma Intratumoral Heterogeneity

open access: yesAdvanced Science, EarlyView.
This review proposes a conceptual framework for understanding glioma intratumoral heterogeneity shaped by neuro‐cancer interactions: functional patterns and transcriptional states. Functional patterns manifest as three major neural‐like adaptations with spatial and potentially hierarchical relationships, including neurogliomal synapses, glioma networks,
Tong Wu   +8 more
wiley   +1 more source

STS-3 medical report [PDF]

open access: yes
The medical operations report for STS-3, which includes a review of the health of the crew before, during, and immediately after the third Shuttle orbital flight is presented.
Johnson, P. C., Jr.   +2 more
core   +1 more source

A Genetically Encoded Biosensor for Characterizing Transport and Metabolism of Glutarate

open access: yesAdvanced Science, EarlyView.
Here, a genetically encoded glutarate biosensor, Glusor, is developed based on transcriptional regulator CsiR. Glusor can quantify glutarate concentrations with good accuracy and precision. Then, the role of KgtP and YnfM are identified and characterized by using Glusor. Glusor also allows glutarate spatiotemporal resolution in live cells, facilitating
Kaiyu Gao   +12 more
wiley   +1 more source

Protein Spatial Structure Meets Artificial Intelligence: Revolutionizing Drug Synergy–Antagonism in Precision Medicine

open access: yesAdvanced Science, EarlyView.
This review comprehensively examines the applications of protein three‐dimensional structures and artificial intelligence in investigating drug synergistic and antagonistic effects. The research findings provide compelling evidence for the precision treatment of cancer and metabolic diseases, thereby promoting the development of personalized medicine ...
Anqi Lin   +11 more
wiley   +1 more source

MICROBIOLOGICAL HYDROXYLATION OF STEROIDS

open access: bronze, 1958
Toshinobu ASAI   +5 more
openalex   +2 more sources

In Vitro Monitoring of Babesia microti Infection Dynamics in Whole Blood Microenvironments

open access: yesAdvanced Science, EarlyView.
Here, an open microfluidic platform termed “µ‐Blood” is reported for real‐time, continuous monitoring of Babesia microti infection dynamics in vitro. µ‐Blood allows direct interrogation of whole blood with preserved integrity of the original whole blood microenvironment through an extended period (e.g., 72 h with mouse red blood cells) ex vivo. µ‐Blood
Chao Li   +4 more
wiley   +1 more source

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