Results 141 to 150 of about 155,517 (332)

Response to Phenotyping the Microcirculation With Contrast-Enhanced Ultrasound [PDF]

open access: bronze, 2012
Harry A.J. Struijker-Boudier   +3 more
openalex   +1 more source

Adipose‐derived small extracellular vesicles exacerbate microvascular dysfunction in heart failure with preserved ejection fraction via mmu‐miR‐582‐3p‐mediated Rap1b suppression

open access: yesInterdisciplinary Medicine, EarlyView.
This study reveals that small extracellular vesicles (sEVs) from visceral fat compromise coronary microcirculation in a mouse model of heart failure with preserved ejection fraction (HFpEF). The SGLT2 inhibitor canagliflozin emerges as a therapeutic strategy, improving cardiac function and endothelial health.
Lu Chen   +12 more
wiley   +1 more source

Organoids and organ‐on‐a‐chip models for investigating the pathophysiology of the human reproductive system

open access: yesInterdisciplinary Medicine, EarlyView.
Organoids and organ‐on‐a‐chips are advancing reproductive system research. In the female reproductive system, applications include cancer organoid models, placental chips, and hormone simulation models. For the male reproductive system, research focuses on drug resistance mechanisms, co‐culture platforms, and infertility studies. These refined in vitro
Hongqi Zhang   +6 more
wiley   +1 more source

Periodontitis and metabolic diseases (diabetes and obesity): Tackling multimorbidity

open access: yesPeriodontology 2000, EarlyView., 2023
Abstract Noncommunicable diseases (NCDs) are multifactorial, long‐term, chronic conditions that represent a burden to health‐care systems worldwide as they can only be controlled rather than cured; hence, they require long‐term care. With the exponential increase in NCDs, the occurrence of individuals presenting with more than one chronic disease is ...
Crystal Marruganti   +2 more
wiley   +1 more source

Comparison of the SMI Technique and CEUS for the Assessment of Microvasculature in Leiomyosarcoma and Its Clinical Value for Application

open access: yesJournal of Clinical Ultrasound, EarlyView.
SMI and CEUS can clearly reflect the microvascular situation in fibroids and effectively guide the clinical treatment of patients with uterine fibroids, but the effect of SMI is better than that of CEUS in guiding the treatment of patients, which can provide a reference for the selection of clinical treatment programs.
Qiufeng Li, Junbin Du
wiley   +1 more source

IL-1β primed mesenchymal stromal cells moderate hemorrhagic shock-induced vascular permeability

open access: yesJournal of Translational Medicine
Background Hemorrhagic shock (HS) corresponds to absolute hypovolemia creating an imbalance between oxygen supply and consumption. This causes an impaired hemostasis, a systemic inflammatory response, and microvascular permeability which can lead to ...
Nathalie Baudry   +7 more
doaj   +1 more source

Investigation Into the Utility of 3D Speckle‐Tracking Echocardiography in Detecting Coronary Artery Microcirculation Dysfunction in Ischemia With Non‐Obstructive Coronary Artery Disease

open access: yesJournal of Clinical Ultrasound, EarlyView.
By detecting the subtle regional contractile dysfunction, 3D‐STE can efficiently distinguish CMCD and present a novel strategy for diagnosing INOCA. ABSTRACT Aim To assess the utility of three‐dimensional speckle‐tracking echocardiography (3D‐STE) in detecting coronary artery microcirculation dysfunction (CMCD) with non‐obstructive coronary artery ...
Yuexia Ma   +5 more
wiley   +1 more source

Non-coding RNAs in the pathophysiology of heart failure with preserved ejection fraction

open access: yesFrontiers in Cardiovascular Medicine
Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still limited, indicating our ongoing incomplete understanding on the ...
Elisabeth A. Jalink   +9 more
doaj   +1 more source

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