Results 71 to 80 of about 100,018 (314)

Modeling the Measurements of Cochlear Microcirculation and Hearing Function after Loud Noise [PDF]

, 2011
Objective: Recent findings support the crucial role of microcirculatory disturbance and ischemia for hearing impairment especially after noise-induced hearing loss (NIHL).
Canis, Martin, Arpornchayanon, Warangkana, Strieth, Sebastian, Markus Suckfuell, Sebastian Strieth, Bernhard Olzowy, Olzowy, Bernhard, Suckfuell, Markus, Ihler, Fritz, Martin Canis, Warangkana Arpornchayanon, Fritz Ihler   +11 more
core   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

A multi-organ atlas of microcirculatory signatures for systemic profiling of diabetic and therapeutic states

Scientific Data
Microcirculatory deterioration in diabetes mellitus causes severe organ-specific complications, yet a systemic understanding of its cross-organ pathophysiology remains elusive due to a lack of comprehensive data.
Yuan Li, Weiqi Liu, Yingyu Wang, Bing Wang, Xiang Xu, Bingwei Li, Xu Zhang, Mingming Liu   +7 more
doaj   +1 more source

Navigating the Landscape of Coronary Microvascular Research: Trends, Triumphs, and Challenges Ahead

Reviews in Cardiovascular Medicine
Coronary microvascular dysfunction (CMD) refers to structural and functional abnormalities of the microcirculation that impair myocardial perfusion. CMD plays a pivotal role in numerous cardiovascular diseases, including myocardial ischemia with non ...
Yingyu Wang, Bing Wang, Hao Ling, Yuan Li, Sunjing Fu, Mengting Xu, Bingwei Li, Xueting Liu, Qin Wang, Ailing Li, Xu Zhang, Mingming Liu   +11 more
doaj   +1 more source

Tumor Exposomics: A New Paradigm for Individualized Continuous Exposure Monitoring

Advanced Science, EarlyView.
Tumor exposomics integrates continuous monitoring of environmental exposures, endogenous biological responses, and behavioral factors within a unified temporal framework. By combining multimodal sensing technologies with AI‐enabled causal modeling, this emerging paradigm reconstructs exposure‐damage trajectories and supports individualized dynamic risk
Kaicheng Shen, Weiyi Wang, Yang Wang, Yiqiang Wu, Xiaohong Liu, Wei Zhang, Juanjuan Ou   +6 more
wiley   +1 more source

Measurement of the blood flow rate and velocity in coronary artery stenosis using intracoronary frequency domain optical coherence tomography: Validation against fractional flow reserve

International Journal of Cardiology: Heart & Vasculature, 2014
Objectives: The main objective of this study was to assess the blood flow rate and velocity in coronary artery stenosis using intracoronary frequency domain optical coherence tomography (FD-OCT). A correlation between fractional flow reserve (FFR) and FD-
Haroon Zafar, Faisal Sharif, Martin J. Leahy   +2 more
doaj   +1 more source

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Pentoxifylline dose finding trial in preterm neonates with suspected late onset sepsis (PTX‐trial)

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study (PTX‐trial) is to determine the optimal dose of pentoxifylline (PTX) in preterm neonates (gestational age < 30 weeks) with (suspected) late onset sepsis (LONS). Methods The PTX‐trial is a prospective multicentre open‐label sequential dose‐optimization study with an adapted continual reassessment method.
Serife Kurul, H. Rob Taal, Jan Mazela, Ryszard Lauterbach, Irwin K. M. Reiss, Karel Allegaert, Robert B. Flint, Sinno H. P. Simons   +7 more
wiley   +1 more source

Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation

Renal Failure
Background Renal microcirculation plays a pivotal role in kidney function by maintaining structural and functional integrity, facilitating oxygen and nutrient delivery, and waste removal.
Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu   +12 more
doaj   +1 more source

Cerebral Microcirculation: Progress and Outlook of Laser Doppler Flowmetry in Neurosurgery and Neurointensive Care [Elektronisk resurs]

Laser Doppler flowmetry (LDF) is a well-established technique for the investigation of tissue microcirculation. Compared to skin, the use in the human brain is sparse.
Zsigmond, Peter,, Wårdell, Karin, Richter, Johan, Richter, Johan,, Zsigmond, Peter, Wårdell, Karin,   +5 more
core   +1 more source