Results 61 to 70 of about 100,018 (314)

Comparative study of the effects of cigarette smoke versus next generation tobacco and nicotine product extracts on endothelial function

Redox Biology, 2021
Tobacco smoking and hemodynamic forces are key stimuli for the development of endothelial dysfunction. As an alternative to smoking, next generation tobacco and nicotine products (NGP) are now widely used.
Sindy Giebe, Anja Hofmann, Melanie Brux, Frazer Lowe, Damien Breheny, Henning Morawietz, Coy Brunssen   +6 more
doaj   +1 more source

The macro- and microcirculation of the kidney

, 2017
Acute kidney injury (AKI) remains one of the main causes of morbidity and mortality in the intensive care medicine today. Its pathophysiology and progress to chronic kidney disease is still under investigation.
Ergin, Bulent, Can Ince, Guerci, Philippe, Ince, Can, Philippe Guerci, Guerci, P, Bulent Ergin   +6 more
core   +1 more source

A Novel IDO1/NE Dual Inhibitor, IMM‐H018 Prevents the Primary and Secondary Sepsis and Ameliorates the Kidney Injury Through Inhibiting the Cytokine Storm and Microthrombosis, and Reversing Immunosuppression

Advanced Science, EarlyView.
IMM‐H018, a dual IDO1/NE inhibitor, demonstrates potent therapeutic efficacy in sepsis by simultaneously targeting excessive inflammation and immune dysfunction. It prevents both primary and secondary sepsis through anti‐inflammatory, immune‐restoring, and renoprotective mechanisms, reducing organ damage, improving immune homeostasis, preserving kidney
Yi Zhou, Xiaodi Zhao, Xiaochen Pan, Zhiling Ma, Huaqing Cui, Hui Wen, Peng Wang, Xiufeng Liao, Kejie Qin, Yuchen Wang, Li Sheng, Sen Zhang   +11 more
wiley   +1 more source

Associations of Menstrual Cycle Regularity and Length With Cardiovascular Diseases: A Prospective Study From UK Biobank

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background The association between menstrual cycle characteristics and cardiovascular outcomes remains unclear. This study was undertaken to evaluate whether menstrual cycle regularity and length throughout the life course are associated with ...
Chensihan Huang, Bingquan Lin, Youwen Yuan, Kangli Li, Bingyan Xu, Peizhen Zhang, Xueyun Wei, Weiwei Wang, Wenhui Liu, Yajuan Deng, Deying Liu, Jiayang Lin, Yan Huang, Huijie Zhang   +13 more
doaj   +1 more source

The medullary microcirculation

Kidney International, 1987
Like other regional circulations, the medullary circulation supplies oxygen and other primary substrates to the medulla and removes carbon dioxide and other waste metabolites. It also acts as a countercurrent exchanger and simultaneously removes water reabsorbed from the renal tubule to preserve mass balance.
Zimmerhackl, Bernd L., Robertson, Channing R., Jamison, Rex L.   +2 more
openaire   +2 more sources

Microcirculation: physiology, pathophysiology, and clinical application [PDF]

, 2020
This paper briefly reviews the physiological components of the microcirculation, focusing on its function in homeostasis and its central function in the realization of oxygen transport to tissue cells. Its pivotal role in the understanding of circulatory
Guven, Goksel; https://orcid.org/, Hilty, Matthias P., Ince, Can, Guven, Goksel, Hilty, Matthias P; https://orcid.org/, Hilty, MP (Matthias)   +5 more
core   +2 more sources

Modulating Calcium Homeostasis via a Biomimetic Scaffold to Rescue Diabetic Ischemic Wounds

Advanced Science, EarlyView.
This strategy addresses impaired microcirculation and loss of extracellular matrix (ECM) guidance in diabetic wound healing. Musc@CP, a nanofibrous dressing combining an ECM‐mimetic chitosan‐pullulan scaffold with muscone, enhances perfusion by attenuating intracellular Ca2+ overload‐associated endothelial dysfunction.
Xiang Zheng, Mingmei Li, Jianjun Jiang, Yongchao Wang, Yaru Jia, Weilun Sun, Yi Yao, Pengli Gao, Linhua Zhang, Qi Guo, Guang Jia, Xing‐Jie Liang, Dunwan Zhu, Jinchao Zhang, Fangzhou Li   +14 more
wiley   +1 more source

The association between hypoalbuminemia and microcirculation, endothelium, and glycocalyx disorders in children with sepsis [PDF]

, 2023
11 páginasObjetivo: El objetivo de este estudio fue evaluar la asociación entre los niveles de albúmina sérica y los cambios en la microcirculación, la degradación del glicocáliz y los resultados clínicos de interés.
Salazar, María Paula, Fernández Sarmiento, Jaime, Barrera, Sofia, Hernández Sarmiento, Ricardo   +3 more
core   +1 more source

Engineering Morphological Anisotropy to Control the In Vivo Transport Dynamics, Clearance, and Biodistribution of Silica Nanocarriers

Advanced Science, EarlyView.
Morphological anisotropy directs the in vivo transport under physiological flow and clearance of silica nanocarriers. Increasing anisotropy reduces cellular uptake, suppresses hepatic and splenic sequestration, and prolongs systemic circulation by steering particles toward the central flow core.
Xiaofei Li, Yingjie Yu, Tianchang He, Xiaoyan Fang, Wenhua Yang, Luying Zhou, Hao Fan, Guimei Lin, Daniel Crespy, Katharina Landfester, Junfeng Zhang, Shuai Jiang   +11 more
wiley   +1 more source

Selenium-Containing Protein From Selenium-Enriched Spirulina platensis Attenuates Cisplatin-Induced Apoptosis in MC3T3-E1 Mouse Preosteoblast by Inhibiting Mitochondrial Dysfunction and ROS-Mediated Oxidative Damage

Frontiers in Physiology, 2019
Accumulated evidences have verified that cancer chemotherapy may increase the risk of osteoporosis and severely affected the life quality. Osteoclasts hyperactivation was commonly accepted as the major pathogenesis of osteoporosis.
Jing-yi Sun, Ya-jun Hou, Xiao-yan Fu, Xiao-ting Fu, Jin-kui Ma, Ming-feng Yang, Bao-liang Sun, Cun-dong Fan, Jinrok Oh   +8 more
doaj   +1 more source