Results 41 to 50 of about 29,995 (215)

Microcirculation: physiology, pathophysiology, and clinical application [PDF]

, 2020
This paper briefly reviews the physiological components of the microcirculation, focusing on its function in homeostasis and its central function in the realization of oxygen transport to tissue cells. Its pivotal role in the understanding of circulatory
Guven, Goksel; https://orcid.org/, Hilty, Matthias P., Ince, Can, Guven, Goksel, Hilty, Matthias P; https://orcid.org/, Hilty, MP (Matthias)   +5 more
core   +2 more sources

Ethical Precision in Nanoscale Brain Interfacing

Advanced Science, EarlyView.
As brain interfaces approach the nanoscale, precision no longer only measures—it knows, predicts, and potentially reshapes the mind. This work argues that traditional ethics fails under such conditions and proposes a shift toward continuous, operation‐based governance using the recovery–discovery framework to track, constrain, and responsibly steer ...
Guilherme Wood
wiley   +1 more source

Accessing depth-resolved high spatial frequency content from the optical coherence tomography signal

Scientific Reports, 2021
Optical coherence tomography (OCT) is a rapidly evolving technology with a broad range of applications, including biomedical imaging and diagnosis. Conventional intensity-based OCT provides depth-resolved imaging with a typical resolution and sensitivity
Sergey Alexandrov, Anand Arangath, Yi Zhou, Mary Murphy, Niamh Duffy, Kai Neuhaus, Georgina Shaw, Ryan McAuley, Martin Leahy   +8 more
doaj   +1 more source

Bioinformatics exploration of potential common therapeutic targets for systemic and pulmonary arterial hypertension-induced myocardial hypertrophy

Acta Biochimica et Biophysica Sinica, 2023
Systemic and pulmonary arterial hypertension (PAH) can induce left and right ventricular hypertrophy, respectively, but common therapeutic targets for both left and right hypertrophy are limited.
Chen Lu, Li Mingjue, Shen Mengjia, Zhu Yingqi, Chen Kaitong, Huang Xiaoxia, Zheng Cankun, Wang Qiancheng, Lin Hairuo, Liao Wangjun, Bin Jianping, Ma Siyuan, Liao Yulin   +12 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Role of GABRD Gene Methylation in the Nucleus Accumbens in Heroin-Seeking Behavior in Rats

Frontiers in Pharmacology, 2021
Epigenetic modifications such as DNA methylation play important roles in regulating gene expression and may mediate neuroplasticity and lead to drug-induced aberrant behaviors.
Qingxiao Hong, Qingxiao Hong, Wenjin Xu, Wenjin Xu, Zi Lin, Jing Liu, Weisheng Chen, Weisheng Chen, Huaqiang Zhu, Huaqiang Zhu, Miaojun Lai, Miaojun Lai, Dingding Zhuang, Dingding Zhuang, Zemin Xu, Zemin Xu, Dan Fu, Dan Fu, Wenhua Zhou, Wenhua Zhou, Huifen Liu, Huifen Liu   +21 more
doaj   +1 more source

Magnetically Guided Macrophage Immunobots Coordinate Iron‐Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy

Advanced Science, EarlyView.
Magnetically guided macrophage immunobots integrate active tumor targeting with immunometabolic therapy. After systemic administration, magnetic actuation enhances immunobot retention and tumor penetration, while LPS‐functionalized FePt microrollers sustain M1‐like polarization through inflammatory and iron‐amplified oxidative signaling and trigger ...
Xirui Zeng, Yingfei Zhang, Chong Wu, Qijia Duan, Mengqi Fan, Kuan Wang, Shirong Cai, Immihan Ceren Yasa   +7 more
wiley   +1 more source

Performance Review of Multiple Reference Versus Time Domain Optical Coherence Tomography

IEEE Photonics Journal, 2018
We present a detailed characterization of noise sources in multiple reference optical coherence tomography (MR-OCT) compared to time-domain OCT (TD-OCT).
Kai Neuhaus, Paul M. McNamara, Sergey Alexandrov, Sean O'Gorman, Josh Hogan, Carol Wilson, Martin J. Leahy   +6 more
doaj   +1 more source

Improving vasculoprotective effects of MSCs in coronary microvessels – benefits of 3D culture, sub-populations and heparin

Frontiers in Immunology, 2023
IntroductionOpening occluded coronary arteries in patients with myocardial infarction (MI) damages the delicate coronary microvessels through a process called myocardial ischaemia-reperfusion injury.
Kobkaew Bumroongthai, Dean P. J. Kavanagh, Paul Genever, Neena Kalia   +3 more
doaj   +1 more source

Programmable Self‐Heating Microneedle Patch for on‐Demand Postprandial Glucose Management

Advanced Science, EarlyView.
A programmable self‐heating microneedle patch enables on‐demand, timed‐sequence insulin delivery via user‐triggered quadrant activation. Each activation generates localized heat that melts a phase‐change barrier, accelerating drug release. In diabetic rats, sequential quadrant activation counteracts four meal‐mimicking glucose spikes over 24 h without ...
Yang Zhao, Guifang Pan, Jincai Zhang, Yue Gong, Wenjian Zhang, Huiling Shen, Xingxing Li, Yuehan Ouyang, Hanhan Xie, Jundong Shao   +9 more
wiley   +1 more source