Results 31 to 40 of about 26,493 (264)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

Astaxanthin Attenuates Homocysteine-Induced Cardiotoxicity in Vitro and in Vivo by Inhibiting Mitochondrial Dysfunction and Oxidative Damage

Frontiers in Physiology, 2017
Homocysteine (Hcy) as an independent risk factor contributes to the occurrence and development of human cardiovascular diseases (CVD). Induction of oxidative stress and apoptosis was commonly accepted as the major mechanism in Hcy-induced cardiotoxicity.
Cun-dong Fan, Jing-yi Sun, Xiao-ting Fu, Ya-jun Hou, Yuan Li, Ming-feng Yang, Xiao-yan Fu, Bao-liang Sun, Bao-liang Sun   +8 more
doaj   +1 more source

Non-invasive imaging of microcirculation: a technology review. [PDF]

, 2014
Microcirculation plays a crucial role in physiological processes of tissue oxygenation and nutritional exchange. Measurement of microcirculation can be applied on many organs in various pathologies.
Sturesson, Christian, Eriksson S, Nilsson, Jan, Nilsson J, Eriksson, Sam, Sturesson C   +5 more
core   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

Mesenteric Lymph Drainage Alleviates Acute Kidney Injury Induced by Hemorrhagic Shock without Resuscitation

The Scientific World Journal, 2014
This study aimed to investigate the effect of mesenteric lymph drainage on the acute kidney injury induced by hemorrhagic shock without resuscitation. Eighteen male Wistar rats were randomly divided into sham, shock, and drainage groups.
Zi-Gang Zhao, Hong-Xia Zhu, Li-Min Zhang, Yu-Ping Zhang, Chun-Yu Niu   +4 more
doaj   +1 more source

Insights into the toxicological effects of nanomaterials on atherosclerosis: mechanisms involved and influence factors

Journal of Nanobiotechnology, 2023
Atherosclerosis is one of the most common types of cardiovascular disease and is driven by lipid accumulation and chronic inflammation in the arteries, which leads to stenosis and thrombosis.
Siyu Chen, Yuan Su, Manjin Zhang, Yulin Zhang, Peiming Xiu, Wei Luo, Qiuxia Zhang, Xinlu Zhang, Hongbin Liang, Alex Pui-Wai Lee, Longquan Shao, Jiancheng Xiu   +11 more
doaj   +1 more source

The Cutaneous Microcirculation [PDF]

Journal of Investigative Dermatology Symposium Proceedings, 2000
The cutaneous microcirculation is organized as two horizontal plexuses. One is situated 1-1.5 mm below the skin surface and the other is at the dermal-subcutaneous junction. Ascending arterioles and descending venules are paired as they connect the two plexuses.
openaire   +2 more sources

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

The Regulatory Role of GBF1 on Osteoclast Activation Through EIF2a Mediated ER Stress and Novel Marker FAM129A Induction

Frontiers in Cell and Developmental Biology, 2021
Bone-resorbing activities of osteoclasts (OCs) are highly dependent on actin cytoskeleton remodeling, plasma membrane reorganization, and vesicle trafficking pathways, which are partially regulated by ARF-GTPases.
Cailing Wen, Yuheng Zhou, Yanting Xu, Huijing Tan, Caixia Pang, Haiqian Liu, Kaifei Liu, Linlin Wei, Hui Luo, Tian Qin, Chonghua He, Cuiling Liu, Chun Zhou   +12 more
doaj   +1 more source

Evaluation of cutaneous microcirculation in systemic sclerosis. An update

, 2023
The impairment of the microcirculation is a crucial aspect of systemic sclerosis which manifests as a plethora of vascular abnormalities. This review examines the methods used in the evaluation of the changes to the microcirculation.
Katarzyna Pawlik, Anna Bohdziewicz, Joanna Czuwara, Małgorzata Olszewska, Jefte Prado, Lidia Rudnicka, Magdalena Maciejewska   +6 more
core   +1 more source