Results 21 to 30 of about 138,918 (303)

Genetic predisposition to porto‐sinusoidal vascular disorder: A functional genomic‐based, multigenerational family study

Hepatology, EarlyView., 2022
A deleterious variant of FCHSD1 results in mTOR pathway overactivation and may cause porto‐sinusoidal vascular disorder (PSVD). The pedigree of the family demonstrated an autosomal dominant disease with variable expressivity. Whole‐genome sequencing and Sanger sequencing both validated the existence of the FCHSD1 variant and the heterozygosity of c ...
Jingxuan Shan, André Megarbane, Aziz Chouchane, Deepak Karthik, Ramzi Temanni, Atilio Reyes Romero, Huiying Hua, Chun Pan, Xixi Chen, Murugan Subramanian, Chadi Saad, Hamdi Mbarek, Cybel Mehawej, Eliane Chouery, Sirin W. Abuaqel, Alexander Dömling, Sami Remadi, Cesar Yaghi, Pu Li, Lotfi Chouchane   +19 more
wiley   +1 more source

p53 SUMOylation Mediates AOPP-Induced Endothelial Senescence and Apoptosis Evasion

Frontiers in Cardiovascular Medicine, 2022
The aging of endothelial cells plays a critical role in the development of age-related vascular disease. We established a model of endothelial premature senescence by application of Advanced oxidation protein products (AOPPs) modified bovine serum ...
Yanjia Chen, Yanjia Chen, Zhuanhua Liu, Hongyu Chen, Xingfu Huang, Xiaoxia Huang, Yang Lei, Qing Liang, Jiayi Wei, Qin Zhang, Xiaohua Guo, Qiaobing Huang   +11 more
doaj   +1 more source

CD11b+CD43hiLy6Clo splenocyte‐derived macrophages exacerbate liver fibrosis via spleen–liver axis

Hepatology, EarlyView., 2022
A population of splenic monocytes migrate into the liver and shift to macrophages, which account for the exacerbation of liver fibrosis. Abstract Background and Aims Monocyte‐derived macrophages (MoMFs), a dominant population of hepatic macrophages under inflammation, play a crucial role in liver fibrosis progression.
Shaoying Zhang, Dan Wan, Mengchen Zhu, Guihu Wang, Xurui Zhang, Na Huang, Jian Zhang, Chongyu Zhang, Qi Shang, Chen Zhang, Xi Liu, Fanfan Liang, Chunyan Zhang, Guangyao Kong, Jing Geng, Libo Yao, Shemin Lu, Yongyan Chen, Zongfang Li   +18 more
wiley   +1 more source

The marginated pool [PDF]

, 2002
The pulmonary circulation harbors a large intravascular reservoir of leukocytes refered to as the Marginated Pool. This marginated pool is balanced by propeling and retaining forces acting on leukocytes during their passage through the pulmonary ...
Goetz, Alwin Eduard, Kuebler, Wolfgang M.   +1 more
core   +1 more source

Combinatorial targeting of G‐protein‐coupled bile acid receptor 1 and cysteinyl leukotriene receptor 1 reveals a mechanistic role for bile acids and leukotrienes in drug‐induced liver injury

Hepatology, EarlyView., 2022
CHIN117 is a dual cysteinyl leukotriene receptor 1 (CYSLTR1) antagonist and G‐protein‐coupled bile acid receptor 1 (GPBAR1) agonist. In the liver, GPBAR1 and CYSLTR1 are coexpressed by liver sinusoidal endothelial cells (LSECs), HSCs, circulating monocytes/macrophages, and liver resident macrophages (Kupffer cells).
Michele Biagioli, Silvia Marchianò, Cristina di Giorgio, Rosalinda Roselli, Martina Bordoni, Rachele Bellini, Bianca Fiorillo, Valentina Sepe, Bruno Catalanotti, Chiara Cassiano, Maria Chiara Monti, Eleonora Distrutti, Angela Zampella, Stefano Fiorucci   +13 more
wiley   +1 more source

Renal microcirculation.

Folia Pharmacologica Japonica, 1999
The blood flow to the kidney averages about 20% of the cardiac output and the renal circulation affects urine formation. The renal microcirculation is unique. Glomerular circulation is mainly regulated by two resistance arterioles, the afferent arteriole and the efferent arteriole.
T, Tamaki, M, Yoshizumi
openaire   +3 more sources

Platelet kinetics in the pulmonary microcirculation in vivo assessed by intravital microscopy [PDF]

, 2002
Growing evidence supports the substantial pathophysiological impact of platelets on the development of acute lung injury. Methods for studying these cellular mechanisms in vivo are not present yet.
Eichhorn, M. E., Goetz, Alwin Eduard, Massberg, S., Ney, L.   +3 more
core   +1 more source

Contrast agents for photoacoustic imaging: a review of stem cell tracking

Stem Cell Research & Therapy, 2021
With the advent of stem cell therapy for spinal cord injuries, stroke, burns, macular degeneration, heart diseases, diabetes, rheumatoid arthritis and osteoarthritis; the need to track the survival, migration pathways, spatial destination and ...
Soorya James, Kai Neuhaus, Mary Murphy, Martin Leahy   +3 more
doaj   +1 more source

Absolute Circulating Pericyte Progenitor Cell Counts in Mice by Flow Cytometry: comparison of 2 single-platform technologies

The International Journal of Biological Markers, 2015
Background Accumulating evidence indicates that circulating pericyte progenitor cells (CPPCs) may be angiogenic biomarkers in cancer and diabetes. Their validity as biomarkers depends on the accuracy of techniques used for enumeration.
Xiaochen Yuan, Qingbin Wu, Hongwei Li, Bingwei Li, Ruijuan Xiu MD, PhD   +4 more
doaj   +1 more source

Chinese herbal remedies affecting thrombosis and hemostasis: A review

World Journal of Traditional Chinese Medicine, 2015
Acute coronary syndrome, stroke and other ischemic events continue to be the most common causes of mortality and morbidity in the world, and their incidence is rapidly increasing in the developing nations.
Quan Li, Jing-Yu Fan, Jing-Yan Han
doaj   +1 more source