Results 81 to 90 of about 197,951 (371)

Integrin α8‐Mediated Pericyte Morphogenesis Controls Blood‐Brain Barrier Integrity

Advanced Science, EarlyView.
This study highlights that ITGA8 impacts pericyte morphology and function, both crucial for BBB integrity, via RhoA/ROCK signaling, thus influencing TGF‐β1 activation through cytoskeletal tension and ECM interactions. Notably, in post‐ischemic recovery models, ITGA8 deficiency exacerbates vascular dysfunction by impairing pericyte‐mediated BBB ...
Chang‐Xiong Gong, Lin‐Lin Hu, Ling Jiang, Pei‐Xia Shi, Shuang Zhang, Yuan Zhao, Bing‐Qiao Wang, Xiao‐Feng Cheng, Cheng‐Kang He, Sen Lin, Yue Dai, Zhao‐You Meng, Chen‐Hao Zhao, Bao‐Liang Sun, Qi Xie, Fang‐Fei Li, Qing‐Wu Yang   +16 more
wiley   +1 more source

Navigating the Landscape of Coronary Microvascular Research: Trends, Triumphs, and Challenges Ahead

Reviews in Cardiovascular Medicine
Coronary microvascular dysfunction (CMD) refers to structural and functional abnormalities of the microcirculation that impair myocardial perfusion. CMD plays a pivotal role in numerous cardiovascular diseases, including myocardial ischemia with non ...
Yingyu Wang, Bing Wang, Hao Ling, Yuan Li, Sunjing Fu, Mengting Xu, Bingwei Li, Xueting Liu, Qin Wang, Ailing Li, Xu Zhang, Mingming Liu   +11 more
doaj   +1 more source

Preload Dependence Is Associated with Reduced Sublingual Microcirculation during Major Abdominal Surgery

Anesthesiology, 2019
What We Already Know about This Topic Whether sublingual microcirculation reflects systemic preload remains unknown What This Article Tells Us That Is New Thirty-two preload dependent episodes were identified in 17 patients Episodes were accompanied by ...
K. Bouattour, J. Teboul, L. Varin, E. Vicaut, J. Duranteau   +4 more
semanticscholar   +1 more source

Predicting optimal hematocrit in silico [PDF]

, 2018
Optimal hematocrit $H_o$ maximizes oxygen transport. In healthy humans, the average hematocrit $H$ is in the range of 40-45$\%$, but it can significantly change in blood pathologies such as severe anemia (low $H$) and polycythemia (high $H$). Whether the
Audemar, Vassanti, Benyoussef, Abdelilah, Coupier, Gwennou, Ez-Zahraouy, Hamid, Farutin, Alexander, Harting, Jens, Misbah, Chaouqi, Podgorski, Thomas, Polack, Benoit, Prado, Gael, Shen, Zaiyi, Vlahovska, Petia M.   +11 more
core   +6 more sources

Tie2‐Dependent Mechanisms Influence Leptomeningeal Collateral Dynamics and Reperfusion Following Stroke

Advanced Science, EarlyView.
This work demonstrates that endothelial EphA4 limits Tie2 activation and curbs leptomeningeal collateral expansion after ischemic stroke. Pharmacological activation of Tie2 by an Ang‐1 mimetic or genetic loss of EphA4 stimulates collateral vessel growth, improves cerebral perfusion, and enhances neurological recovery.
Alexandra M. Kaloss, Caroline de Jager, Kennedie Lyles, Nathalie A. Groot, Jackie Zhu, Yu Lin, Michael Chen, Hehuang Xie, John B. Matson, Michelle H. Theus   +9 more
wiley   +1 more source

Measurement of the blood flow rate and velocity in coronary artery stenosis using intracoronary frequency domain optical coherence tomography: Validation against fractional flow reserve

International Journal of Cardiology: Heart & Vasculature, 2014
Objectives: The main objective of this study was to assess the blood flow rate and velocity in coronary artery stenosis using intracoronary frequency domain optical coherence tomography (FD-OCT). A correlation between fractional flow reserve (FFR) and FD-
Haroon Zafar, Faisal Sharif, Martin J. Leahy   +2 more
doaj   +1 more source

STING signaling sensing of DRP1-dependent mtDNA release in kupffer cells contributes to lipopolysaccharide-induced liver injury in mice

Redox Biology, 2022
Aberrant pro-inflammatory activation of Kupffer cells (KCs) is strongly involved in the pathogenesis of septic liver injury. Recent evidence indicates the crucial roles of excessive stimulator of interferon genes (STING) signaling activation during ...
Qin Zhang, Jiayi Wei, Zhuanhua Liu, Xiaoxia Huang, Maomao Sun, Wujiang Lai, Zhenfeng Chen, Jie Wu, Yanjia Chen, Xiaohua Guo, Qiaobing Huang   +10 more
doaj   +1 more source

Mathematical modeling of local perfusion in large distensible microvascular networks [PDF]

, 2016
Microvessels -blood vessels with diameter less than 200 microns- form large, intricate networks organized into arterioles, capillaries and venules. In these networks, the distribution of flow and pressure drop is a highly interlaced function of single ...
Causin, Paola, Malgaroli, Francesca
core   +2 more sources

Multimodal Imaging Reveals Cerebral Microcirculation Dynamics and Mechanisms in Mouse Central Nervous System After Intranasal Infection With Recombinant Pseudorabies Virus

Advanced Science, EarlyView.
Multi‐modality imaging strategy applied to PRV‐induced central nervous system infection enables dynamic visualization of cerebrovascular dysfunction, including hyperemia, hypoperfusion, and vascular remodeling. These changes are linked to microglial activation and impaired angiogenesis, providing mechanistic insight into PRV neuropathogenesis and ...
Shuting Ling, Chongxin Wu, Mengxuan Gui, Kaiyun Chen, Yanbo Yang, Jiwei Xing, Fengxian Du, Wei Liao, Luyao Yang, Zhaokui Jin, Ningshao Xia, Guosong Wang, Yixin Chen, Qingliang Zhao   +13 more
wiley   +1 more source

Tiny clue reveals the general trend: a bibliometric and visualized analysis of renal microcirculation

Renal Failure
Background Renal microcirculation plays a pivotal role in kidney function by maintaining structural and functional integrity, facilitating oxygen and nutrient delivery, and waste removal.
Bing Wang, Mengting Xu, Sunjing Fu, Yingyu Wang, Hao Ling, Yuan Li, Bingwei Li, Xueting Liu, Qin Ouyang, Xiaoyan Zhang, Ailing Li, Xu Zhang, Mingming Liu   +12 more
doaj   +1 more source