Results 51 to 60 of about 23,887 (275)

Increased Prorenin Expression in the Kidneys May Be Involved in the Abnormal Renal Function Caused by Prolonged Environmental Exposure to Microcystin-LR

Toxics
Toxic algae in eutrophic lakes produce cyanotoxic microcystins. Prior research on the effect of microcystin-LR in the kidney utilized intraperitoneal injections, which did not reflect natural exposure.
Yuuka Hitsuda, Yoshihito Koto, Hideaki Kawahara, Koichi Kurata, Keisuke Yoshikiyo, Kohji Nishimura, Ayumi Hashiguchi, Hideaki Maseda, Kunihiro Okano, Norio Sugiura, Kazuya Shimizu, Hidehisa Shimizu   +11 more
doaj   +1 more source

The Use of Sodium Hypochlorite at Point-of-Use to Remove Microcystins from Water Containers

Toxins, 2021
Most conventional water treatment plants are not sufficiently equipped to treat both intracellular and extracellular Microcystins in drinking water. However, the effectiveness of sodium hypochlorite in removing Microcystin in containers at the point-of ...
Matodzi Michael Mokoena, Lutendo Sylvia Mudau, Matlou Ingrid Mokgobu, Murembiwa Stanley Mukhola   +3 more
doaj   +1 more source

Cyanopeptide Mixtures Induce Variable Synergistic and Antagonistic Effects Across Diverse Human Cell Lines

Environmental Toxicology, EarlyView.
ABSTRACT Cyanobacterial harmful algal blooms (cyanoHABs) threaten human, animal, and ecosystem health and safety through production of toxic secondary metabolites. Microcystis, a cosmopolitan bloom‐forming cyanobacterial genus, is well‐known for producing hepatotoxic microcystins (MCs), but it can produce many other bioactive cyanopeptides, such as ...
Lauren N. Hart, Katherine L. Lev, Sierra Hefferan, Sanduni H. Premathilaka, Sharmila I. Thenuwara, Dragan Isailovic, David H. Sherman, Gregory J. Dick   +7 more
wiley   +1 more source

Biodegradation of [D-Leu1] microcystin-LR by a bacterium isolated from sediment of Patos Lagoon estuary, Brazil

Journal of Venomous Animals and Toxins including Tropical Diseases, 2015
Background Toxic cyanobacterial blooms are recurrent in Patos Lagoon, in southern Brazil. Among cyanotoxins, [D-Leu1] microcystin-LR is the predominant variant whose natural cycle involves water and sediment compartments. This study aimed to identify and
Gilmar AF Lemes, Luiza W Kist, Mauricio R Bogo, João S Yunes   +3 more
doaj   +1 more source

Microcystins: Potent xenobiotics

Archive of Oncology, 2011
Having in mind that exposure to low levels of microcystin in drinking water represents the health risk for people, microcystins can be observed as potent xenobiotics. The consequences of exposure to natural products of the blue-green algae, the microcystins, are numerous.
Maja Ilic, Zorica Svircev, Vladimir Baltic   +2 more
openaire   +3 more sources

Exploring the Key Role of Nanotechnology on Intratumoral Microbiome Modulation for Cancer Immunotherapy

MedComm – Biomaterials and Applications, Volume 5, Issue 1, March 2026.
The review provides a comprehensive analysis of microbiome‐mediated oncogenic mechanisms in various cancers, emphasizing the unique therapeutic strategies facilitated by nanotechnology. It aims to fill this gap by systematically reviewing nanotechnology‐driven strategies for microbiome elimination, with a focus on their ability to improve the cold TME ...
Yumei Gan, Yan Zhang, Xia Dong, Feng Lv
wiley   +1 more source

PARP1 Is Up-Regulated in Non-small Cell Lung Cancer Tissues in the Presence of the Cyanobacterial Toxin Microcystin

Frontiers in Microbiology, 2018
Non-small cell lung cancer (NSCLC) is the major form of lung cancer, with adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC) being its major subtypes. Smoking alone cannot completely explain the lung cancer etiology.
Patrick L. Apopa, L. Alley, R. Penney, K. Arnaoutakis, Mathew A. Steliga, S. Jeffus, Emine Bircan, B. Gopalan, Jing Jin, P. Patumcharoenpol, Piroon Jenjaroenpun, T. Wongsurawat, N. Shah, G. Boysen, D. Ussery, I. Nookaew, P. Fagan, G. Bebek, Mohammed S Orloff   +18 more
semanticscholar   +1 more source

Drinking Water Quality Regulations: A Contrast Between Germany and Latin America

Environmental Quality Management, Volume 35, Issue 3, Spring 2026.
ABSTRACT This article investigates the differences among drinking water quality standards adopted in Latin American countries, Mexico, Cuba, and the European Union, considering the growing challenge of ensuring safe drinking water in a context marked by environmental pressures, climate change, and the occurrence of emerging contaminants. The study aims
Eduardo Saldanha Vogelmann, Juliana Prevedello, Gizachew Ayalew Tiruneh   +2 more
wiley   +1 more source

Selectivity and potency of microcystin congeners against OATP1B1 and OATP1B3 expressing cancer cells. [PDF]

PLoS ONE, 2014
Microcystins are potent phosphatase inhibitors and cellular toxins. They require active transport by OATP1B1 and OATP1B3 transporters for uptake into human cells, and the high expression of these transporters in the liver accounts for their selective ...
Timo H J Niedermeyer, Abigail Daily, Monika Swiatecka-Hagenbruch, Jeffrey A Moscow   +3 more
doaj   +1 more source

Characterization of Aerosols Containing Microcystin [PDF]

Marine Drugs, 2007
Toxic blooms of cyanobacteria are ubiquitous in both freshwater and brackishwater sources throughout the world. One class of cyanobacterial toxins, calledmicrocystins, is cyclic peptides. In addition to ingestion and dermal, inhalation is a likelyroute of human exposure.
Lorraine C. Backer, Barbara Kirkpatrick, C. Mitch Irvin, Zhou Yue, Yung Sung Cheng   +4 more
openaire   +3 more sources