Results 21 to 30 of about 47,561 (246)
Microdissection—An Essential Prerequisite for Spatial Cancer Omics
Proteomics, 2020 The problem with cancer tissue is that its intratumoral heterogeneity and its complexity is extremely high as cells possess, depending on their location and function, different mutations, different mRNA expression and the highest intricacy in the protein
F. Eggeling, F. Hoffmann
semanticscholar +1 more source
Identification of Distinct Immune Subtypes in Colorectal Cancer Based on the Stromal Compartment
Frontiers in Oncology, 2020 The tumor environment is of vital importance for the incidence and development of colorectal cancer. Increasing evidence in recent years has elaborated the vital role of the tumor environment in cancer subtype classification and patient prognosis, but a ...
Rongfang Shen +5 more
doaj +1 more source
Microdissection of the Human Renal Nervous System
HYPERTENSION, 2020 Despite the use of renal denervation to treat hypertension, the anatomy of the renal nervous system remains poorly understood. We performed a detailed quantitative analysis of the human renal nervous system anatomy with the goal of optimizing renal ...
A. García-Touchard +3 more
semanticscholar +1 more source
Extracellular vesicles: mediators and biomarkers of pathology along CNS barriers
Fluids and Barriers of the CNS, 2018 Extracellular vesicles (EVs) are heterogeneous, nano-sized vesicles that are shed into the blood and other body fluids, which disperse a variety of bioactive molecules (e.g., protein, mRNA, miRNA, DNA and lipids) to cellular targets over long and short ...
Servio H. Ramirez +3 more
doaj +1 more source
Nature Genetics, 2015 Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease with a 5-year survival rate of 4%. A key hallmark of PDAC is extensive stromal involvement, which makes capturing precise tumor-specific molecular information difficult.
Richard A Moffitt +17 more
semanticscholar +1 more source
Neoplasia: An International Journal for Oncology Research, 2007 Synchronous primary breast cancer describes the occurrence of multiple tumors affecting one or both breasts at initial diagnosis. This provides a unique opportunity to identify tissue-specific genomic markers that characterize each tumor while ...
Arezou A. Ghazani +6 more
doaj +1 more source
Experimental microdissection enables functional harmonization of pancreatic cancer subtypes
Gut, 2019 Objective Pancreatic ductal adenocarcinoma (PDA) has among the highest stromal fractions of any cancer and this has complicated attempts at expression-based molecular classification.
Carlo Maurer +15 more
semanticscholar +1 more source
Penile Microdissection: A Live Donor Feasibility Study in Feminizing Gender-Affirming Surgery
Life, 2023 Femininizing gender affirmation surgery includes the creation of external female genitalia such as a new clitoris, labia, and vagina with removal of the glans and urethral remnants and full corpora cavernosa.
Slavica Pusica +5 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2001 In spite of intensive and increasingly successful attempts to determine the multiple steps involved in colorectal carcinogenesis, the mechanisms responsible for metastasis of colorectal tumors to the liver remain to be clarified.
Rempei Yanagawa +7 more
doaj +1 more source
Computer-aided laser dissection: A microdissection workflow leveraging image analysis tools
Journal of Pathology Informatics, 2018 Introduction: The development and application of new molecular diagnostic assays based on next-generation sequencing and proteomics require improved methodologies for procurement of target cells from histological sections.
Jason D Hipp +14 more
doaj +1 more source