Results 41 to 50 of about 1,131 (169)

Assessing a Model for a Complex Systemic Disorder—The Value of Male Mice With a Supernumerary X Chromosome for Klinefelter Syndrome Research

Andrology, EarlyView.
ABSTRACT Introduction Direct experimental investigation of Klinefelter syndrome (KS) in patients is limited because the syndrome manifests heterogeneously and affects multiple organ systems. Studying KS therefore requires a model that captures this complexity as accurately as possible while still permitting controlled experimental manipulation ...
Fariba Saadati, Joachim Wistuba
wiley   +1 more source

Machine Learning‐Based Prediction of Sperm Retrieval Outcomes in Patients With Klinefelter Syndrome: A Multicenter Study With External Validation

Andrology, EarlyView.
ABSTRACT Background The Klinefelter syndrome is a common genetic cause of male infertility, and testicular sperm extraction (TESE) enables sperm retrieval in a subset of affected patients. However, predicting TESE success remains challenging due to the heterogeneous clinical and endocrinological presentation of the Klinefelter syndrome.
Murat Gül, Ali Şahin, Cevahir Özer, Mesut Altan, Tansu Güdelci, Kadir Can Sahin, Mehmet Hamza Gültekin, Muhammed Arif İbis, Mesut Berkan Duran, Burak Sivaslıoğlu, Eray Hasırcı, Mert Kılıç, Ali Can Albaz, Gökhan Çeker, Gianmaria Salvio   +14 more
wiley   +1 more source

Sperm retrieval techniques in azoospermic patients: PESA, MESA, TESA, TESE and MICROTESE [PDF]

Einstein (São Paulo), 2009
Azoospermia is defined as the absence of mature spermatozoa in semen analysis after centrifugation. The causes of azoospermia may be related to spermatogenesis defects and classified as non-obstructive azoospermia, or to the obstruction of the efferent ...
Marcelo Vieira, Sidney Glina
doaj  

Microdissection testicular sperm extraction (micro-TESE): Predictive value of preoperative hormonal levels and pathology in non-obstructive azoospermia

Kaohsiung Journal of Medical Sciences, 2018
The aim of this study was to evaluate the predictive value of preoperative hormonal levels and pathology, as well as the outcome of microsurgical testicular sperm extraction in patients with non-obstructive azoospermia (NOA), presenting to our clinic for
Alper Eken, Feray Gulec
doaj   +1 more source

Revisiting non‐obstructive azoospermia: Is there a best way to retrieve testicular sperm?

Reproductive Medicine and Biology
Background Microdissection TESE has been considered the “gold standard” for retrieving testicular sperm in cases of non‐obstructive azoospermia (NOA) despite limited scientific support. Here we compare all aspects of microdissection TESE with testis fine
Satoru Kanto, Kentaro Ichioka, Yuri Sato, Yoshihiko Uchino, Takayuki Tanaka, Mareyuki Endo   +5 more
doaj   +1 more source

Predictive factors shaping fertility potential and reproductive outcomes in men with Klinefelter syndrome

Asian Journal of Andrology
Klinefelter syndrome (KS), marked by testicular heterogeneity, provides a rationale for testicular sperm extraction in azoospermic men, yet large-scale evaluations of predictive and reproductive outcomes remain limited.
Itai Atar, Shimi Barda, Yael Kalma, Sandra E Kleiman, Foad Azem, Ron Hauser, Snir Dekalo, Noga Fuchs Weizman   +7 more
doaj   +1 more source

ICSI outcome after microdissection testicular sperm extraction, testicular sperm aspiration and ejaculated sperm

Reproductive Biology
We conducted a case-controlled single-center cohort study to evaluate the intracytoplasmic sperm injection (ICSI) outcome in severe male infertility with different methods of sperm obtention. The data was compiled from a tertiary university hospital.
Rauni Klami, Candido Tomás, Harri Mankonen, Antti Perheentupa   +3 more
openaire   +2 more sources

Serum testosterone levels and other determinants of sperm retrieval in microdissection testicular sperm extraction [PDF]

Translational Andrology and Urology, 2017
Microdissection testicular sperm extraction (microTESE) has become the standard of care for sperm retrieval in non-obstructive azoospermia (NOA) patients. Understanding the significant determinants of microTESE outcomes may result in improvements in sperm retrieval rates and provide better-informed clinical decisions.This is a clinical retrospective ...
Althakafi, Sultan A., Mustafa, Osama M., Seyam, Raouf M., Al-Hathal, Naif, Kattan, Said   +4 more
openaire   +2 more sources

Future prospects for the advancement of treatment of men with NOA: focus on gene editing, artificial sperm, stem cells, and use of imaging

Asian Journal of Andrology
Nonobstructive azoospermia (NOA) affects about 60% of men with azoospermia, representing a severe form of male infertility. The current approach to manage NOA primarily involves testicular sperm retrieval methods such as conventional testicular sperm ...
Akeem Babatunde Sikiru, Manh Nguyen Truong, Wael Zohdy   +2 more
doaj   +1 more source

Predictive factors of successful sperm retrieval on microdissection testicular sperm extraction in Japanese men [PDF]

Reproductive Medicine and Biology, 2015
AbstractPurposeTo evaluate retrospectively the outcomes of microdissection testicular sperm extraction (micro‐TESE) in men with nonobstructive azoospermia (NOA) and to identify the parameters predicting successful sperm retrieval in this cohort of patients.MethodsAfter excluding patients with normal testicular volume and serum follicle‐stimulating ...
Noritoshi, Enatsu, Hideaki, Miyake, Koji, Chiba, Masato, Fujisawa   +3 more
openaire   +2 more sources