Results 61 to 70 of about 1,131 (169)
Microdissection testicular sperm extraction for men undergoing cancer treatment [PDF]
Expert Review of Quality of Life in Cancer Care, 2016 ABSTRACTSteady improvements in the long term outlook for adolescents and young adults with cancer require a shift in focus towards ensuring quality of life after cancer treatment as well as quantity. An important component of quality of life for many men is the ability to father a biological child.
Thomas, J +3 more
openaire +2 more sources
Testicular mRNA‐LNP Delivery: A Novel Therapy for Genetic Spermatogenic Disorders
Advanced Science, Volume 13, Issue 22, 17 April 2026.In the current study, we developed a novel therapy for genetic spermatogenic disorders. It was revealed that in vivo delivery of mRNA LNP3 could restore spermatogenesis in Msh5D486Y/D486Y and Maps KO mouse models with meiotic arrest. Notably, the offspring without genomic integration was born using ICSI derived from the rescue of Msh5D486Y/D486Y mouse ...
Chenwang Zhang +22 more
wiley +1 more source
Clinical and Experimental Obstetrics & Gynecology, 2020 The authors report a unique case of a successful live birth in an infertile couple both with male factor (idiopathic hypogonadotropic hypogonadism, IHH/azoospermia) and female factor [atypical polypoid adenomyoma (APA) of the uterus].
K. Okuno +5 more
doaj +1 more source
Endothelial PDGF Signaling Dysregulation Impairs Testicular Interstitial Homeostasis in Diabetes
Advanced Science, Volume 13, Issue 21, 13 April 2026.Testicular endothelial cells (TECs) function as central signaling hubs that coordinate interstitial homeostasis. Diabetes disrupts TEC‐derived PDGF signaling, silences the JUND‐MCL1 survival program in Leydig cells, and impairs peritubular function, leading to fibrosis and testosterone insufficiency.
Wenxiu Zhang +14 more
wiley +1 more source
Advanced Science, Volume 13, Issue 13, 3 March 2026.Spermatogonial stem cells (SSCs) provide critical support to spermatogenesis. Here, the author established Il1r2 as a sorting marker for SSCs, with which further insights into the SSC heterogeneity and dynamic features can be obtained. They also confirmed findings in both mouse and human, thus validating IL1R2 as the surface marker for isolating and ...
Pengyu Li +19 more
wiley +1 more source
Urology Case Reports, 2019 Men with non-obstructive azoospermia (NOA) are candidates for microdissection testicular sperm extraction (microTESE). In men with NOA and varicocele, varicocelectomy has been associated with the appearance of sperm in the ejaculate.
Mohannad Alharbi, Armand Zini
doaj +1 more source
Guideline of guidelines: management of small testicular masses
BJU International, Volume 137, Issue 3, Page 444-453, March 2026.Objective To compare and summarise the most up to date international guidelines and major recommendations for the management of small testicular masses (STMs). Methods A systematic search was conducted in PubMed, EMBASE, Scopus, Google Scholar, and the Cochrane Library up to 1 November 2024.
Marco Tozzi +7 more
wiley +1 more source
Current Treatment Patterns and Outcomes of Sex Cord Stromal Tumor Patients in Japan
International Journal of Urology, Volume 33, Issue 3, March 2026.ABSTRACT Objectives Sex cord‐stromal tumors (SCSTs) constitute approximately 5% of testicular malignancies. This investigation aimed to elucidate contemporary therapeutic approaches and clinical outcomes for patients with testicular SCSTs in Japan. Methods Participating institutions included Japan Clinical Oncology Group facilities, affiliated centers,
Takashige Abe +16 more
wiley +1 more source
Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.ABSTRACT Purpose In mouse embryos derived from round spermatid injection (ROSI), low developmental potential due to abnormal histone modification is improved by histone deacetylase (HDAC) inhibitors. However, some studies suggest that the use of such inhibitors leads to the birth of hypomorphic offspring.
Seiji Watanabe +9 more
wiley +1 more source