Results 141 to 150 of about 778,156 (254)

Is resting muscle sympathetic nerve activity related to peripheral or cerebrovascular haemodynamics at high altitude? A retrospective analysis

Experimental Physiology, EarlyView.
Abstract High‐altitude hypoxia elicits several profound physiological responses, including substantial increases in muscle sympathetic nerve activity (MSNA); however, the association of this heightened MSNA with cardiovascular and cerebrovascular haemodynamics remains unclear in lowlanders and indigenous highlander populations.
Ty J. A. MacDonald, Jenna C. McCrone, Christabel Osei‐Boateng, Connor D. Wideman, Samantha L. Tsioros, Joshua C. Tremblay, Alexander Patrician, Connor A. Howe, Geoff B. Coombs, Benjamin S. Stacey, Lydia L. Simpson, Mike Stembridge, Craig D. Steinback, Jonathan P. Moore, Travis D. Gibbons, Ryan L. Hoiland, Francisco Villafuerte, Gilbert Moralez, Philip N. Ainslie, Michael M. Tymko   +19 more
wiley   +1 more source

New Methods for the Site-Selective Placement of Peptides on a Microelectrode Array: Probing VEGF–v107 Binding as Proof of Concept

, 2016
Cu­(I)-catalyzed “click” reactions cannot be performed on a borate ester derived polymer coating on a microelectrode array because the Cu­(II) precursor for the catalyst triggers background reactions between both acetylene and azide groups with the ...
Matthew D. Graaf (1434328), Bernadette V. Marquez (470753), Kevin D. Moeller (1434331), Suzanne E. Lapi (389414), Nai-Hua Yeh (2099614)   +4 more
core   +1 more source

Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans

Experimental Physiology, EarlyView.
Abstract Sympathetic nervous system activation is a hallmark of high‐altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors – two excitatory pathways co‐activated by hypoxia – to sustained sympathoexcitation at altitude.
Michiel T. Ewalts, Lydia L. Simpson, Jack S. Talbot, Elliott J. Jenkins, Travis D. Gibbons, Connor A. Howe, Lauren E. Maier, Emily R. Vanden Berg, Alex M. Williams, Philip N. Ainslie, Samuel J. Oliver, Craig D. Steinback, Mike Stembridge, Jonathan P. Moore   +13 more
wiley   +1 more source

Age‐related loss of hysteresis in the spontaneous vascular sympathetic baroreflex is associated with altered neural rather than mechanical control

Experimental Physiology, EarlyView.
Abstract The vascular sympathetic baroreflex is critical for stabilising blood pressure. A notable feature of this reflex is hysteresis, a directional asymmetry in responsiveness during rising versus falling pressure that is evident in young adults but attenuated in older age.
Guto Wyn Hughes, Denis J. Wakeham, Christopher J. A. Pugh, Zoe H. Adams, Rachel N. Lord, Jonathan P. Moore   +5 more
wiley   +1 more source

Pulmonary arterial mechanoreceptors modulate exercise‐induced sympathetic activation in healthy humans during moderate‐intensity hypoxic exercise

The Journal of Physiology, EarlyView.
Abstract figure legend This randomized cross‐over trial (N = 12) addressed the hypothesis that selective reduction of pulmonary arterial pressure (i.e. manipulation of pulmonary arterial mechanoreceptor activation) during hypoxic exercise would reduce sympathetic outflow (muscle sympathetic nerve activity (MSNA)) in healthy humans.
Michiel T. Ewalts, Thomas D. Griffiths, Andrew J. M. Douglas, Elliott J. Jenkins, Guto Wyn Hughes, Craig D. Steinback, Lydia L. Simpson, Samuel J. Oliver, Mike Stembridge, Jonathan P. Moore   +9 more
wiley   +1 more source

A local de-insulation method and its application in neural microneedle array

Microsystems & Nanoengineering
Silicon-based neural microneedle arrays, such as the Utah Array, have demonstrated excellent performance in chronic recordings from the cerebral cortex.
Xin Zhao, Chunrong Wei, Deguang Zhu, Xiaowei Yang, Guowei Han, Jin Ning, Qiang Gui, Rongyu Tang, Yijun Wang, Jingfeng Zhou, Zhaoxin Geng, Weihua Pei   +11 more
doaj   +1 more source

Human‐derived cardiac‐neural microtissues reveal catecholaminergic polymorphic ventricular tachycardia is also a disease of the sympathetic neuron

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic diagram illustrating the proposed pathway in which regulatory defects might occur in sympathetic neurons derived from hiPSC in catecholaminergic polymorphic ventricular tachycardia (CPVT). Specifically, enhanced calcium transients appeared to derive from three sources: enhanced membrane excitability (due to loss of ...
Ni Li, Chenchen Zhang, Mengying Xu, YoonYoung Choi, Davi Sidarta‐Oliveira, Ruirui Dong, Xinyu Hu, Enrique M. Toledo, Cesar A. Prada‐Medina, Finbar Argus, Kun Liu, Mingyu Li, Linna Zhou, Hagan Bayley, Corey Smith, Chris Denning, Ana I. Domingos, Guoliang Hao, Dan Li, David J. Paterson   +19 more
wiley   +1 more source

Cell Surface Charge Mapping Using a Microelectrode Array on ITO Substrate. [PDF]

Cells, 2023
Ouyang L, Shaik R, Xu R, Zhang G, Zhe J.
europepmc   +1 more source

Channelrhodopsin ion selectivity determines mechanisms and efficacy of optogenetic defibrillation in human atria and ventricles

The Journal of Physiology, EarlyView.
Abstract figure legend A, we used in silico models of human cardiomyocytes and microelectrode recordings on transgenic zebrafish hearts to study electrophysiology during optogenetic perturbations. Specifically, we compared effects of three distinct classes of channelrhodopsins: the cation non‐selective Chlamydomonas reinhardtii channelrhodopsin‐2 (ChR2)
Sophia Ohnemus, Albert Dasí, Ahmed F. Ramadan, Joachim Greiner, Eike M. Wülfers, Matthew R. Stoyek, Linda Tillert, Johannes Vierock, T. Alexander Quinn, Peter Kohl, Patrick M. Boyle, Viviane Timmermann, Franziska Schneider‐Warme   +12 more
wiley   +1 more source

A flexible protruding microelectrode array for neural interfacing in bioelectronic medicine. [PDF]

Microsyst Nanoeng, 2022
Steins H, Mierzejewski M, Brauns L, Stumpf A, Kohler A, Heusel G, Corna A, Herrmann T, Jones PD, Zeck G, von Metzen R, Stieglitz T.   +11 more
europepmc   +1 more source