Results 101 to 110 of about 734,316 (316)
Esophageal Microenvironment: From Precursor Microenvironment to Premetastatic Niche.
Cancer management and research, 2020 Esophageal cancer (EC) is the sixth most deadly cancer, and its incidence is still increasing year by year. Although the researches on the molecular mechanisms of EC have been widely carried out and incremental progress has been made, its overall survival rate is still low. There is cumulative evidence showing that the esophageal microenvironment plays
Han,Peng +6 more
openaire +4 more sources
, 2023 Chemoresistance is a significant problem in the effective treatment of bone metastasis. Adipocytes are a major stromal cell type in the bone marrow and may play a crucial role in developing microenvironment-driven chemoresistance.
Jun-Goo Kwak, Jungwoo Lee
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CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Drug Design, Development and TherapyYa Xu,1– 3 Weijia Xiang,1– 3 Wanyi Zhu,1– 3 Lanqi Shang,1– 3 Mengting Lun,1– 3 Songyan Qu,1– 3 Yizhen Yin,1– 3 Changrong Chen,4 Honggang Yuan,5 Yinhong Song1– 3 1Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges ...
Xu Y +9 more
doaj
N-cadherin crosstalk with integrin weakens the molecular clutch in response to surface viscosity
Nature CommunicationsMesenchymal stem cells (MSCs) interact with their surroundings via integrins, which link to the actin cytoskeleton and translate physical cues into biochemical signals through mechanotransduction.
Eva Barcelona-Estaje +8 more
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Nature Communications, 2020 The transcription factor Zeb1 is known to promote tumorigenesis and stemness in breast cancer. Here the authors show that tumor endothelial Jagged1 induces activation of Notch1 signaling and increases Zeb1 expression in neighboring breast cancer stem ...
Huimin Jiang +14 more
doaj +1 more source
Targeting the Tumor Microenvironment in Neuroblastoma: Recent Advances and Future Directions
, 2020 Neuroblastoma (NB) is the most common pediatric tumor malignancy that originates from the neural crest and accounts for more than 15% of all the childhood deaths from cancer.
Shweta Joshi
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth
Nature Communications, 2020 Proline metabolism is crucial to tumor proliferation. Here, the authors show PINCH-1 deficiency inhibited proline synthesis by promoting mitochondrial fragmentation via DRP1, downregulating PYCR1 expression and reducing cell proliferation in vitro and in
Ling Guo +9 more
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Editorial for Special Issue “Brain Tumor Microenvironment”
The tumor microenvironment (TME) is a complex interplay of cells, extracellular matrix, and signaling molecules that significantly influences tumor growth, invasion, and resistance to therapy [...
Gianluca Trevisi, Annunziato Mangiola
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