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CCL2 in the Tumor Microenvironment
2021The C-C motif chemokine ligand 2 (CCL2) is a crucial mediator of immune cell recruitment during microbial infections and tissue damage. CCL2 is also frequently overexpressed in cancer cells and other cells in the tumor microenvironment, and a large body of evidence indicates that high CCL2 levels are associated with more aggressive malignancies, a ...
O'Connor, T., Heikenwälder, M.
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Targeting the microenvironment
Leukemia & Lymphoma, 2010The microenvironment in which cancer arises plays a critical role in tumorigenesis. Although previously regarded as an innocent bystander, evidence has accumulated over the past 10 years that the microenvironment contributes to tumor growth and progression by providing nutrients and survival signals, and protecting the tumor from normal immune ...
John, Gribben +3 more
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Immunology Today, 1993
Abstract The thymus has been recognized as a site of primary immune function for more than three decades and yet, despite intense research, many of the central questions regarding its function in T-lymphocyte maturation have remained unanswered. Current cellular and molecular analytical techniques are finally proving to be sophisticated enough to ...
R L, Boyd +9 more
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Abstract The thymus has been recognized as a site of primary immune function for more than three decades and yet, despite intense research, many of the central questions regarding its function in T-lymphocyte maturation have remained unanswered. Current cellular and molecular analytical techniques are finally proving to be sophisticated enough to ...
R L, Boyd +9 more
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The Hematopoietic Microenvironment
New England Journal of Medicine, 1980IN this issue of the Journal, Ershler et al. present the most compelling evidence to date for the existence of a naturally occurring human disease of the hematopoietic microenvironment. Their patient had long-standing and probably congenital anemia due to failure of maturation of erythroid precursors in the marrow.
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2010
Recent advances in stem cell and developmental neurobiology have uncovered new perspectives from which we investigate various forms of cancer. Specifically, the hypothesis at tumors are comprised of a subpopulation of malignant cells similar to stem cells is of great interest to scientists and clinicians and has been dubbed the cancer stem cell ...
Lissa, Baird, Alexey, Terskikh
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Recent advances in stem cell and developmental neurobiology have uncovered new perspectives from which we investigate various forms of cancer. Specifically, the hypothesis at tumors are comprised of a subpopulation of malignant cells similar to stem cells is of great interest to scientists and clinicians and has been dubbed the cancer stem cell ...
Lissa, Baird, Alexey, Terskikh
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The adipocyte microenvironment and cancer
Cancer and Metastasis Reviews, 2022Many epithelial tumors grow in the vicinity of or metastasize to adipose tissue. As tumors develop, crosstalk between adipose tissue and cancer cells leads to changes in adipocyte function and paracrine signaling, promoting a microenvironment that supports tumor growth.
Abir Mukherjee +2 more
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The hematopoietic microenvironment
Critical Reviews in Oncology/Hematology, 1991Hematopoietic microenvironment is comprised of an admixture of several adherent cell types including fibroblasts, reticular adventitial cells, and marcophages. The biologic interaction of these cells with the most primitive hematopoietic progenitor cells capable of reconstituting all hematopoietic lineages within an irradiated host, as well as ...
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The Mammary Tumor Microenvironment
2020A developing breast tumor is regulated by its tumor microenvironment (TME) which includes various immune cell subsets, fibroblasts, adipocytes, and endothelial and epithelial cells surrounded by an extracellular matrix (ECM). Breast tissue density is also a defining feature of breast cancer and plays an integral role in the exchange of biochemical cues
Colleen S, Curran, Suzanne M, Ponik
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Dissecting the Marrow Microenvironment
Annals of the New York Academy of Sciences, 1999Abstract: Cloned human stromal cell lines representing functionally distinct cellular components of the marrow microenvironment were generated to serve as tools for identifying gene products that regulate hematopoiesis. Oligonucleotide arrays, or “gene chips” were used to provide a comprehensive comparison of gene expression among the cell lines.
B, Torok-Storb +5 more
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Metabolism in the Tumor Microenvironment
2020From a general perspective, in the context of solid tumors, we can distinguish metabolic alterations of cancer cells from those of the stroma. These two components interact with each other and with the extracellular matrix (ECM), and these interactions can take the form of either metabolic competition or metabolic symbiosis.
Francesca, Montenegro +1 more
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