Results 71 to 80 of about 388,737 (337)

Automated microfluidic platform for dynamic and combinatorial drug screening of tumor organoids

Nature Communications, 2020
Three-dimensional (3D) cell culture technologies, such as organoids, are physiologically relevant models for basic and clinical applications. Automated microfluidics offers advantages in high-throughput and precision analysis of cells but is not yet ...
Brooke Schuster, M. Junkin, S. S. Kashaf, I. Romero-Calvo, Kori Kirby, Jonathan Matthews, C. Weber, A. Rzhetsky, K. White, S. Tay   +9 more
semanticscholar   +1 more source

On‐Demand Activation of Thin Alginate Shell Encapsulated Volatile Liquid for Untethered Pneumatic Soft Actuation

Advanced Engineering Materials, EarlyView.
Phase‐changing liquids enable untethered pneumatic actuation in soft robotics but suffer from volatility and storage challenges. This work reports a simple method to encapsulate Novec 7000 within micron‐thin alginate shells via in situ injection and ionic crosslinking.
Rayan A. M. Basodan, Jack Keddie, Byoungyoul Park, Hyun‐Joong Chung   +3 more
wiley   +1 more source

High-throughput on-chip DNA fragmentation [PDF]

, 2010
free microfluidic deoxyribonucleic acid (DNA) fragmentation chip that is based on hydrodynamic shearing. Genomic DNA has been reproducibly fragmented with 2-10 kbp fragment lengths by applying hydraulic pressure ΔP across micromachined constrictions in ...
Berg, A. van den, Bomer, J.G., Carlen, E.T., Jin, M., Shui, L.   +4 more
core   +1 more source

Numerical simulation of a multi-inlet microfluidic device for biosensing purposes in osteoporosis management [PDF]

, 2019
Objectives In this paper, the effect of the position of the inlet and outlet microchannels on the flow profile and the geometry of the recognition chamber for sample pre-treatment in an electrochemical biosensor to be used in osteoporosis management were
Adibi, Hossein, Amoabediny, Ghassem, Khashayar, Patricia, Larijani, Bagher, Okhovat, Amir, Vanfleteren, Jan, Windels, Jindrich   +6 more
core   +1 more source

Instrument-free, CRISPR-based diagnostics of SARS-CoV-2 using self-contained microfluidic system

Biosensors & bioelectronics, 2021
Rapid and sensitive detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is critical for early diagnostics and timely medical treatment of coronavirus disease 2019 (COVID-19).

semanticscholar   +1 more source

3D (Bio) Printing Combined Fiber Fabrication Methods for Tissue Engineering Applications: Possibilities and Limitations

Advanced Functional Materials, EarlyView.
Biofabrication aims at providing innovative technologies and tools for the fabrication of tissue‐like constructs for tissue engineering and regenerative medicine applications. By integrating multiple biofabrication technologies, such as 3D (bio) printing with fiber fabrication methods, it would be more realistic to reconstruct native tissue's ...
Waseem Kitana, Indra Apsite, Leonid Ionov   +2 more
wiley   +1 more source

Design automation based on fluid dynamics [PDF]

, 2017
This article was accepted and presented at the 9th International Workshop on Bio-Design Automation, Pittsburgh, Pennsylvania (2017).Microfluidic devices provide researchers with numerous advantages such as high throughput, increased sensitivity and ...
Densmore, Douglas, Lashkaripour, Ali, Lippai, Joshua, Sanka, Radhakrishna   +3 more
core  

Microfluidic immunomagnetic multi-target sorting – a model for controlling deflection of paramagnetic beads [PDF]

, 2011
We describe a microfluidic system that uses a magnetic field to sort paramagnetic beads by deflecting them in the direction normal to the flow. Our experiments systematically study the dependence of the beads’ deflection on: bead size and susceptibility,
Griffiths, I. M., Stone, H. A., Tsai, S. S. H.   +2 more
core   +2 more sources

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, EarlyView.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Construction of a Highly Stable Water-Based Release Agent via 1:1 Silicone Oil-Cyclotetrasiloxane Synergy

Molecules
This study develops a high-performance water-based mold release agent for polyurethane (PU) foaming applications. We demonstrate that incorporating octamethylcyclotetrasiloxane (D4) into a dimethyl silicone oil emulsion (5 vol% fixed concentration ...
Can Wang, Yutong Han, Xiaojuan Du, Sihan Guo, Qiming Zhao, Xiao Chen   +5 more
doaj   +1 more source