Results 81 to 90 of about 388,737 (337)

Cutting-Edge Technologies for Inflamed Joints on Chip: How Close Are We?

Frontiers in Immunology, 2022
Osteoarthritis (OA) is a painful and disabling musculoskeletal disorder, with a large impact on the global population, resulting in several limitations on daily activities.
Emine Kahraman, Emine Kahraman, Emine Kahraman, Ricardo Ribeiro, Ricardo Ribeiro, Meriem Lamghari, Meriem Lamghari, Estrela Neto, Estrela Neto   +8 more
doaj   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

A Low-Cost Handheld Centrifugal Microfluidic System for Multiplexed Visual Detection Based on Isothermal Amplification

Sensors
A low-cost, handheld centrifugal microfluidic system for multiplexed visual detection based on recombinase polymerase amplification (RPA) was developed.
Nan Wang, Xiaobin Dong, Yijie Zhou, Rui Zhu, Luyao Liu, Lulu Zhang, Xianbo Qiu   +6 more
doaj   +1 more source

Tumor-on-a-chip: Perfusable vascular incorporation brings new approach to tumor metastasis research and drug development

Frontiers in Bioengineering and Biotechnology, 2022
The extracellular matrix interacts with cancer cells and is a key factor in the development of cancer. Traditional two-dimensional models cannot mimic the natural in situ environment of cancer tissues, whereas three-dimensional (3D) models such as ...
Ruixin Wang, Chenghao Zhang, Danxue Li, Yang Yao   +3 more
doaj   +1 more source

Microporous Microgel Assemblies Facilitating the Recruitment and Osteogenic Differentiation of Progenitor Cells for Bone Regeneration

Advanced Functional Materials, EarlyView.
There is a significant need for biomaterials with well‐defined stability and bioactivity to support tissue regeneration. In this study, we developed a tunable microgel platform that enables the decoupling of stiffness from porosity, thereby promoting bone regeneration.
Silvia Pravato, Haishuo Guan, Bianca M. Carrara, Mira Jacobs, Matteo Monticelli, Lukas Moser, Thomas Moragues, Andrew J. deMello, Tomaso Zambelli, Martin Ehrbar   +9 more
wiley   +1 more source

Machine learning for microfluidic design and control

Lab on a Chip, 2022
Microfluidics has developed into a mature field with applications across science and engineering, having particular commercial success in molecular diagnostics, next-generation sequencing, and bench-top analysis.
David McIntyre, A. Lashkaripour, P. Fordyce, D. Densmore   +3 more
semanticscholar   +1 more source

Unleashing the Power of Machine Learning in Nanomedicine Formulation Development

Advanced Functional Materials, EarlyView.
A random forest machine learning model is able to make predictions on nanoparticle attributes of different nanomedicines (i.e. lipid nanoparticles, liposomes, or PLGA nanoparticles) based on microfluidic formulation parameters. Machine learning models are based on a database of nanoparticle formulations, and models are able to generate unique solutions
Thomas L. Moore, Cristiano Pesce, Antonietta Greco, Claudia Pisante, Greta Avancini, Valentina Di Francesco, Yosi Shamay, Paolo Decuzzi   +7 more
wiley   +1 more source

A novel strategy for controllable electrofabrication of molecularly imprinted polymer biosensors utilizing embedded Prussian blue nanoparticles

Scientific Reports
The reproducibility of ultrasensitive biosensors is vital for clinical research, scalable manufacturing, commercialization, and reliable clinical decision-making, as batch-to-batch variations introduce significant uncertainty.
Bahareh Babamiri, Mohammadreza Farrokhnia, Mehdi Mohammadi, Amir Sanati Nezhad   +3 more
doaj   +1 more source

Development of a microfluidic unit for sequencing fluid samples for composition analysis [PDF]

, 2004
A microfluidic sample-sequencing unit was developed as a part of a high-throughput catalyst screening facility. It may find applications wherever a fluid is to be selected for analysis from any one of several sources, such as microreactors operating in ...
Adams, Ehrfeld, J.R. Tippetts, Priestman, R.W.K. Allen, Stone, Tesař, Tesař, Tesař, Tesař, Tesař, Tesař, V. Tesař, Wilkin, Y.Y. Low   +14 more
core   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source