Results 101 to 110 of about 122,783 (311)

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Integrated microfluidic tmRNA purification and real-time NASBA device for molecular diagnostics. [PDF]

, 2008
We demonstrate the first integrated microfluidic tmRNA purification and nucleic acid sequence-based amplification (NASBA) device incorporating real-time detection.
Antonio J. Ricco, Breadmore, Bryan Lincoln, Cady, Caroline Viguier, Chen, Chen, Chung, Claus R. Poulsen, Compton, Cremonesi, Dittrich, Easley, Fu-Chun Huang, Glynn, Glynn, Gulliksen, Gulliksen, Ivan K. Dimov, Jaykus, Jose L. Garcia-Cordero, Justin O'Grady, Keiler, Khandurina, Lee, Lee, Legendre, Leone, Lien, Linder, Liu, Lorcan Kent, Luke P. Lee, Majella Maher, Monis, Nagrath, O' Grady, Paul Daly, Richard O'Kennedy, Sia, Terry J. Smith, Toriello, Tyagi, Tyagi, Tyagi, Waters, Younan Xia, Zhang, Zhang   +48 more
core   +1 more source

Development of a Synthetic Hydrogel to Foster Microvascularization of an Endometriosis Microphysiological System

Advanced Healthcare Materials, EarlyView.
ABSTRACT The ascent of novel alternative methods in drug development spotlights the dual needs for improved biological fidelity to in vivo, along with reproducibility, especially in regulatory applications. The need for pre‐clinical models of patient‐derived endometriosis lesions motivates the development of a vascularizable, completely synthetic ...
Lauren Pruett, Laura Bahlmann, Ryan Ogi, Angela Jiao, Priyatanu Roy, Matthew Johnson, David Trumper, Linda Griffith   +7 more
wiley   +1 more source

Dynamic Pattern Formation in a Vesicle-Generating Microfluidic Device [PDF]

, 2001
Spatiotemporal pattern formation occurs in a variety of nonequilibrium physical and chemical systems. Here we show that a microfluidic device designed to produce reverse micelles can generate complex, ordered patterns as it is continuously operated far ...
Arnold, Frances H., Quake, Stephen R., Roberts, Richard W., Thorsen, Todd   +3 more
core   +1 more source

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Improved continuous magnetic separation assisted with advection flows in microfluidic channels [PDF]

, 2019
Department of Biomedical EngineeringMagnetophoretic separation efficiency is determined by a ratio of magnetic particles isolated by magnetic flux density gradients.
Jung, Su Hyun
core  

Classification of large circulating tumor cells isolated with ultra-high throughput microfluidic Vortex technology. [PDF]

, 2016
Circulating tumor cells (CTCs) are emerging as rare but clinically significant non-invasive cellular biomarkers for cancer patient prognosis, treatment selection, and treatment monitoring.
Che, James, Dhar, Manjima, Di Carlo, Dino, Garon, Edward B, Goldman, Jonathan, Heirich, Kyra, Jeffrey, Stefanie S, Kulkarni, Rajan P, Matsumoto, Melissa, Pegram, Mark D, Rao, Jianyu, Renier, Corinne, Sheth, Shruti, Sledge, George W, Sollier, Elodie, Yu, Victor   +15 more
core   +2 more sources

Copper–Collagen Interactions Regulate the Mechanical and Invasive Properties of Tumor Spheroids

Advanced Healthcare Materials, EarlyView.
Ionic copper is investigated as a modulator of tumor spheroid growth and invasiveness in a 3D microfluidic glioblastoma model. Copper exposure alters metabolic activity, cytoskeletal organization, protrusion dynamics, and EMT‐related phenotypes in a dose‐ and timing‐dependent manner, revealing how copper bioavailability shapes tumor aggressiveness ...
Paula Guerrero‐López, Jose I. Garcia‐Peiro, Felipe Hornos, Jose L. Hueso, Jesus Santamaria, J. Manuel Garcia‐Aznar   +5 more
wiley   +1 more source

Hybrid Integrated Silicon Microfluidic Platform for Fluorescence Based Biodetection

Sensors, 2007
The desideratum to develop a fully integrated Lab-on-a-chip device capable ofrapid specimen detection for high throughput in-situ biomedical diagnoses and Point-of-Care testing applications has called for the integration of some of the novel ...
André Darveau, Ion Stiharu, Muthukumaran Packirisamy, Kim Young Soo, Jian Liang You, Ashwin Acharya, Arvind Chandrasekaran   +6 more
doaj   +1 more source