Results 171 to 180 of about 235,228 (311)

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Recovery of microglial function and reduction of amyloid pathology by silencing p16^Ink4a.

reservedL'accumulo di placche amiloidi nel cervello è una caratteristica tipica della malattia di Alzheimer (AD). Questo processo è accompagnato da una progressiva riduzione dell'efficienza della microglia, le cellule immunitarie del sistema nervoso ...
FERRARESE, VERONICA
core  

miR-19a-3p and miR-19b-3p Promote Microglia Activation Associated With Neuroinflammation. [PDF]

J Neurosci Res
Sahebdel F, Battaglino RA, Morse LR, Olson JK.   +3 more
europepmc   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease. [PDF]

iScience
Rogers BB, Anderson AG, Rodriguez-Nunez I, Bartley SC, Johnston SQ, Taylor JW, Meadows SK, Newberry KM, Myers RM, Cochran JN.   +9 more
europepmc   +1 more source

Retinal Microglia

Investigative Opthalmology & Visual Science, 2012
Jost B, Jonas, Xiulan, Zhang, Rutledge, Ellis-Behnke   +2 more
openaire   +2 more sources

Descriptive Epidemiology From the Myhre Syndrome Foundation Registry: The Value of Self‐Reported Data

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome is an ultrarare genetic disease characterized by short stature, distinct craniofacial features, cardiovascular and respiratory fibrosis and stenosis, neurodevelopmental delays, autism, intellectual disability, and hearing loss. The natural history of Myhre syndrome is still not fully understood due to a small patient population ...
Mary K. Young, Armelle Pindon, Maggie R. Brand, Kate Wears, Katherine H. Young, Alyssa Mendel, Michael J. Lyons   +6 more
wiley   +1 more source

Multi-dimensional decoding of the TSPO signal in animal models of neuroinflammation using fluorescence-conjugated DPA714. [PDF]

J Neuroinflammation
Song H, Zhu Z, Xiao L, Zhao Q, Li C, Lv A, Yu X, Gao Z, Lin J, Wang Y, Zhang Y, Zhang L, Li R, Yao S, Cui M, Lin Y, Fu Y, Yong VW, Li R.   +18 more
europepmc   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Aging reprograms microglia toward an inflammasome-linked response to traumatic brain injury. [PDF]

J Clin Invest
Morganti JM, Bachstetter AD.
europepmc   +1 more source