Results 181 to 190 of about 315,527 (297)

Microglia-Astrocyte Cooperation and Peripheral T Cells in Alzheimer's Disease: State-of-the-Art and Treatment Perspectives. [PDF]

Int J Mol Sci
Bivona G, Ghersi G.
europepmc   +1 more source

Temporal Interference Stimulation Enhances Neural Regeneration

Advanced Science, EarlyView.
Temporal interference (TI) stimulation is proposed as a non‐invasive approach to enhance neural regeneration in the deep brain. Theta‐band TI modulation selectively promotes neural progenitor cell differentiation in vitro and augments hippocampal neurogenesis in amouse model of Alzheimer's disease‐like amyloidosis.
Sofia Peressott, Maria Garcia Garrido, Patrycja Dzialecka, Rachel Man Hoi Law, Roberto Portillo‐Lara, Bethany Geary, Elena Faillace, Shirine Merlo‐Nikpay Aslie, Marcelina Wojewska, Maria Otero‐Jimenez, Martina Genta, Luqiao Tan, Karen Duff, Javier Alegre‐Abarrategui, Rylie Green, Nir Grossmann   +15 more
wiley   +1 more source

Immune signaling and function in neurodegeneration. [PDF]

J Clin Invest
Latour YL, McGavern DB.
europepmc   +1 more source

Senomorphic Small Extracellular Vesicles Delivered by a Tissue‐Adhesive α‐Lipoic‐Acid Hydrogel Enable Immuno‐Rejuvenation for Bone‐Tendon Interface Regeneration

Advanced Science, EarlyView.
This work identifies M1 macrophage‐mediated inflammation as a key driver of BMSC senescence and bone microstructural deterioration at the enthesis. A tissue‐adhesive hydrogel delivering senomorphic small extracellular vesicles suppresses this inflammatory‐senescent cascade and enhances BMSC resilience by inhibiting the cGAS‐STING‐NF‐κB pathway.
Lingzhi Kong, Wei Song, Wencai Liu, Hui Xu, Yuhao Yu, Xinyue Yang, Haiyan Li, Yanlun Zhu, Yaohua He   +8 more
wiley   +1 more source

Kv1.3 as an upstream regulator of oxidative stress-mediated neuroinflammation following organic dust exposure in murine <i>in vitro</i>, <i>ex vivo</i>, and <i>in vivo</i> models. [PDF]

Front Toxicol
Massey N, Bhat SM, Shrestha D, Malovic E, Karriker LA, Choudhary S, Robertson AP, Nguyen HM, Wulff H, Kanthasamy AG, Charavaryamath C.   +10 more
europepmc   +1 more source

Functional Disorder at the Neural Interface: How Disordered Nanostructures Promote Proper Growth and Differentiation in In Vitro Neural Cultures

Advanced Science, EarlyView.
This work provides a practical guide for neuroengineers to design advanced neural interfaces, embracing and tailoring the concept of functional disorder. By bridging 2D and 3D in vitro models, this work highlights how non‐periodic, spatially heterogeneous, multiscale nanotopography can enable more physiologically relevant platforms for studying neural ...
F. Maita, E. Palmieri, I. Lucarini, L. Montaina, L. Maiolo   +4 more
wiley   +1 more source

Cell Type-Specific Expression of p16, p21, and p53 Reveals Age-Dependent Glial Senescence in the App^NL-G-F Mouse Model of Alzheimer's Disease. [PDF]

Aging Cell
Sweeney EM, Abate G, Bakker BRV, Mastinu A, Lai Y, Uberti D, Nilsson P, Tambaro S.   +7 more
europepmc   +1 more source

Biallelic mutations in NRROS cause an early onset lethal microgliopathy. [PDF]

, 2020
Armishaw, J, Barrington, J, Bridges, LR, Clarke, A, Crow, YJ, Eaton, J, Hobbs, V, Jeffrey, IJM, Livingston, JH, Mansour, S, McColl, BW, Nolan, M, Patir, A, Rice, GI, Rodero, MP, Seabra, L, Smith, C, Uggenti, C   +17 more
core   +2 more sources

Friend, Not Foe: Lowered Tissue Reactivity to Long‐Term Polyimide Implants

Advanced Science, EarlyView.
The choice of optimal neural probe designs remains a major challenge in the field of neurotechnology. This study investigated the biocompatibility of several probe variations, including material, thickness, width, and implantation strategy. It highlights the clear advantage of soft polyimide probes over stiff silicon probes for better device ...
Corinne Orlemann, Laura M. De Santis, Paul Neering, Christian Boehler, Kirti Sharma, Arno Aarts, Tobias Holzhammer, Rik J. J. van Daal, Patrick Ruther, Maria Asplund, Roxana N. Kooijmans, Pieter R. Roelfsema   +11 more
wiley   +1 more source

Research progress on the regulation of microglia and astrocyte functions by protein lactylation in cerebral ischemia-reperfusion injury: A review. [PDF]

Medicine (Baltimore)
Song HH, Jiang XC.
europepmc   +1 more source