Results 211 to 220 of about 315,527 (297)

Persistent microglial activation following neonatal CMV infection mediates neurodegeneration. [PDF]

Sci Adv
McCord JL, Chatterjee D, Han JYS, Scoles D, Smeyne RJ, Philp NJ, Snyder CM.   +6 more
europepmc   +1 more source

A Skull Bone Marrow‐to‐Brain Axis Links Osteoblastic Activity to Myeloid Cell Trafficking, Cerebral Blood Flow, and Cognition in Alzheimer's Progression

Advanced Science, EarlyView.
This study reveals that Alzheimer's disease–linked APP expression in bone‐forming cells drives skull bone marrow remodeling and alters its vascular connections to the brain. These changes disrupt immune cell trafficking, cerebral blood flow, and cognition. Targeting bone marrow macrophages restores brain function, highlighting a previously unrecognized
Lei Xiong, Dong Sun, Hao‐Han Guo, Daehoon Lee, Zhipeng Liu, Lin Mei, Wen‐Cheng Xiong   +6 more
wiley   +1 more source

<i>RBFOX1</i> Dysfunction Unlocks <i>APOE4</i>-Associated Microglial Genesis and Exacerbates Alzheimer's Pathology in Human Cerebral Organoids. [PDF]

Exploration (Beijing)
Zhang B, Shi C, Zhao J, Hua Q, Zhang H, Gao H, Qian Y, Cha J, Li J, Chen J, Kim TH, Xue J, Hou Y, Zhang R.   +13 more
europepmc   +1 more source

Reduced CB1 Cannabinoid Receptor Expression in Alzheimer's Disease and Transgenic Mouse Models

AGING MEDICINE, EarlyView.
CB1 receptor (CB1R) expression was significantly reduced in the hippocampus, medial frontal gyrus, and superior temporal gyrus of Alzheimer's patients. CB1R levels negatively correlated with amyloid‐β and tau pathology. In addition, CB1R expression was also reduced in the cortex of 5xFAD mice and in the hippocampus of Tg4‐42 mice.
Nike von Borcke, Amrei Vivian Purwien, Annik Steiert, Henrike Hasecke, Yvonne Bouter   +4 more
wiley   +1 more source

Microglia cause HIV-induced transcriptional and metabolic changes in human neural organoids. [PDF]

Commun Biol
Capendale PE, Helgers LC, Ambikan AT, Vieira de Sá R, Wolthers KC, Geijtenbeek TBH, Sridhar A, Neogi U, Pajkrt D.   +8 more
europepmc   +1 more source

Cell Segmentation Beyond 2D—A Review of the State‐of‐the‐Art

Advanced Intelligent Discovery, EarlyView.
Cell segmentation underpins many biological image analysis tasks, yet most deep learning methods remain limited to 2D despite the inherently 3D nature of cellular processes. This review surveys segmentation approaches beyond 2D, comparing 2.5D and fully 3D methods, analyzing 31 models and 32 volumetric datasets, and introducing a unified reference ...
Fabian Schmeisser, Haseeb Muhammad, Junaid Younas, Gillian Lovell, Bianca Migliori, Andreas Dengel, Sheraz Ahmed   +6 more
wiley   +1 more source

Deletion of SPI1 in microglia exacerbates amyloid pathology by impairing microglial response in Alzheimer's disease models. [PDF]

Neuron
Kim B, Tate MD, Karahan H, Wijeratne HRS, Sharify AD, Wang SS, Kim JR, Al-Amin MM, Hartigan K, Chung S, Dabin LC, Acri DJ, Doud EH, John SK, Mosley AL, Kim J.   +15 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Microglia Rank signaling regulates GnRH neuronal function and the hypothalamic-pituitary-gonadal axis. [PDF]

Science
Collado-Sole A, Borjini N, Zhai J, Ruiz-Pino F, Soria-Alcaide G, Folgueira C, García-Vilela C, Romero-de la Rosa B, Lopez V, Zouaghi Y, Jacobs A, Mora-Romero B, Barranco A, Yoldi G, Rizzoti K, Sabio G, Perez-Chacon G, Santamaria PG, Esteban JA, Journiac N, Prevot V, Pascual A, Fernández-Chacón R, Tena-Sempere M, Pitteloud N, Gonzalez-Suarez E.   +25 more
europepmc   +1 more source