Results 221 to 230 of about 249,102 (311)

Targeting the microglial phosphatidylethanolamine synthesis pathway promotes GABARAP-associated phagocytosis and Aβ clearance in Alzheimer's disease. [PDF]

Signal Transduct Target Ther
Hyeon SJ, Kim SC, Chu J, Kim Y, Kim C, Park U, Tufail Z, Thi Thanh Nguyen P, Eom A, Kim S, Kim Y, Lee E, Kim S, Lee SE, Woo J, Lee JA, Lee KE, Stein TD, Lee H, Lee J, Ryu H.   +20 more
europepmc   +1 more source

On the evolution of microglia

Zoological Research
Wu, Zhisheng, Cui, Rongfeng, Li, Hanjie
openaire   +2 more sources

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Mild Subcortical Stroke Induces Widespread Chronic Reactive Astrogliosis That Is Largely Unaffected by Microglia and Age. [PDF]

ASN Neuro
Stackhouse TL, Marxmiller BD, Sullivan SJ, McConnell HL, Knittel LM, De La Torre R, Houser A, Ismail O, Zhang W, Woltjer RL, Mishra A.   +10 more
europepmc   +1 more source

Artificial Intelligence‐Driven Network Pharmacology: A Methodological Paradigm Shift Bridging Traditional Wisdom and Modern Science

Advanced Intelligent Discovery, EarlyView.
Artificial intelligence is redefining network pharmacology (NP). By integrating knowledge graph engineering, geometric deep learning, multiomics anchoring, and generative reasoning, AI‐driven NP (AI‐NP) transforms static target mapping into dynamic, predictive modeling.
Cong Wang, Sile Hu, Rigahai Ji, Riguna A, Siqige Hao, Ma Zhuo, Yi‐Hung Chen, Bisihalatu Hu, Ulana Bai, Xigui Hada   +9 more
wiley   +1 more source

Mitochondrial microprotein MOCCI controls neuroinflammation by altering glial activation states. [PDF]

Front Immunol
Shen K, Guo K, Leong SH, Lim R, Chew WL, Lee CQE, Ho L.   +6 more
europepmc   +1 more source

OXidative Stress PREDictor: A Supervised Learning Approach for Annotating Cellular Oxidative Stress States in Inflammatory Cells

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
OxSpred, an eXtreme‐Gradient‐Boosting‐‐based supervised learning model, accurately annotates oxidative stress in innate immune cells at the single‐cell level, providing interpretable embeddings with significant biological relevance. This innovative tool revolutionizes the understanding of innate immune cell functions during inflammation and enhances ...
Po‐Yuan Chen, Tai‐Ming Ko
wiley   +1 more source

Stimulus-Based ApoE Alzheimer's Disease Induction Model Using Microglia-Containing Brain Organoids for Drug Discovery. [PDF]

Cells
Yuan NY, Richards WD, Parham KT, Clark SG, Lebakken CS.   +4 more
europepmc   +1 more source

Severe ADEM‐Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Heterozygous germline variants in CBL disrupt its function as a negative regulator of the Ras/MAPK pathway, classically predisposing to Juvenile myelomonocytic leukemia (JMML) and moyamoya. We describe two affected siblings carrying a paternally inherited CBL variant (c.1210 T> C, p.
Michal Bar‐Hakim, Anat Abramovich, Sara Via‐Dorembus, Gali Heimer, Bruria Ben‐Zeev, Etai Adam, Assaf A. Barg, Jonathan Roth, Basheer Sheick‐Yousif, Rony Beeri Berkowiz, Michal Feldon, Haim Bassan, Moran Hausman‐Kedem   +12 more
wiley   +1 more source

Monomethyl Fumarate Modulates Iron Metabolism and Mitochondrial Function in Microglia with Implications for Multiple Sclerosis Progression. [PDF]

Cell Mol Neurobiol
Dann J, Klöster K, Ceylan U, Heitmann N, Eggers B, Rozanova S, Eisenacher M, Marcus-Alic K, Winklhofer KF, Gold R, Faissner S.   +10 more
europepmc   +1 more source