Results 221 to 230 of about 203,390 (263)
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2022
Microglia, a category of glial cells in the central nervous system (CNS), have attracted much attention because of their important role in neuroinflammation. Many translational studies are currently ongoing to discover novel drugs targeting microglia for the treatment of various CNS disorders, such as Alzheimer's disease, Parkinson's disease (PD), and ...
Tomomitsu, Iida +2 more
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Microglia, a category of glial cells in the central nervous system (CNS), have attracted much attention because of their important role in neuroinflammation. Many translational studies are currently ongoing to discover novel drugs targeting microglia for the treatment of various CNS disorders, such as Alzheimer's disease, Parkinson's disease (PD), and ...
Tomomitsu, Iida +2 more
openaire +2 more sources
Biological Reviews, 2021
ABSTRACTMicroglial cells are the scions of foetal macrophages which invade the neural tube early during embryogenesis. The nervous tissue environment instigates the phenotypic metamorphosis of foetal macrophages into idiosyncratic surveilling microglia, which are generally characterised by a small cell body and highly ramified motile processes that ...
Marcus Augusto‐Oliveira +5 more
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ABSTRACTMicroglial cells are the scions of foetal macrophages which invade the neural tube early during embryogenesis. The nervous tissue environment instigates the phenotypic metamorphosis of foetal macrophages into idiosyncratic surveilling microglia, which are generally characterised by a small cell body and highly ramified motile processes that ...
Marcus Augusto‐Oliveira +5 more
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Microscopy Research and Technique, 2001
AbstractThis paper reviews the various proposed hypotheses on the origin of microglia. The seminal study of del Rio‐Hortega first stated that the cells were derived from the mesodermal pial cells that invaded the brain during embryonic development. Along with this was the description of precursor cells in the yolk sac in early development.
Kaur, C. +3 more
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AbstractThis paper reviews the various proposed hypotheses on the origin of microglia. The seminal study of del Rio‐Hortega first stated that the cells were derived from the mesodermal pial cells that invaded the brain during embryonic development. Along with this was the description of precursor cells in the yolk sac in early development.
Kaur, C. +3 more
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Glia, 1993
AbstractThe most characteristic property of microglia is their swift activation in response to neuronal stress and their capacity for site‐directed phagocytosis. The transformation of microglia into intrinsic brain macrophages appears to be under strict control and takes place if neuronal and/or terminal degeneration occurs in response to nerve lesion.
R B, Banati +3 more
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AbstractThe most characteristic property of microglia is their swift activation in response to neuronal stress and their capacity for site‐directed phagocytosis. The transformation of microglia into intrinsic brain macrophages appears to be under strict control and takes place if neuronal and/or terminal degeneration occurs in response to nerve lesion.
R B, Banati +3 more
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Neuropharmacology
TREM2 is a membrane receptor solely expressed on microglia in normal brain. In this review we outline recent advances in TREM2 biology and its implications for microglial function, with particular emphasis on findings from iPSC-derived microglia (iMG) expressing TREM2 loss-of-function mutations.
Jennifer Pocock +3 more
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TREM2 is a membrane receptor solely expressed on microglia in normal brain. In this review we outline recent advances in TREM2 biology and its implications for microglial function, with particular emphasis on findings from iPSC-derived microglia (iMG) expressing TREM2 loss-of-function mutations.
Jennifer Pocock +3 more
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Microglia in neuroregeneration
Microscopy Research and Technique, 2001AbstractMicroglia has the potential to produce and release a range of factors that directly and/or indirectly promote regeneration in the injured nervous system. The overwhelming evidence indicates, however, that this potential is generally not expressed in vivo.
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Acta Neuropathologica, 1985
Using an ammoniacal silver nitrate stain, we have demonstrated typical microglial cells in three teratomas. Microglia appeared identical to their counterparts in the mature human brain, both resting and slightly hypertrophic types being present in differentiated nervous tissue, which also comprised astrocytes, neurones and ependyma. The implications of
PESCE, CARLO, Tobia F, Scott T.
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Using an ammoniacal silver nitrate stain, we have demonstrated typical microglial cells in three teratomas. Microglia appeared identical to their counterparts in the mature human brain, both resting and slightly hypertrophic types being present in differentiated nervous tissue, which also comprised astrocytes, neurones and ependyma. The implications of
PESCE, CARLO, Tobia F, Scott T.
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Myeloid cells are fundamental constituents of the brain tumor microenvironment. In this chapter, we describe the state-of-the-art knowledge on the role of microglial cells in the cross-talk with the most common and aggressive brain tumor, glioblastoma. We report in vitro and in vivo studies related to glioblastoma patients and glioma models to outline ...
Stefano, Garofalo +2 more
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Stefano, Garofalo +2 more
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Microglial cells are unique tissue-resident macrophages located in the parenchyma of the central nervous system (CNS). A recent comparative transcriptional study on microglia across more than 20 species from leach across chicken and many more up to humans revealed multiple conserved features.
Elena, Guffart, Marco, Prinz
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Elena, Guffart, Marco, Prinz
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CNS & Neurological Disorders - Drug Targets, 2011
Microglia, the tissue macrophages of the brain, have under healthy conditions a resting phenotype that is characterized by a ramified morphology. With their fine processes microglia are continuously scanning their environment. Upon any homeostatic disturbance microglia rapidly change their phenotype and contribute to processes including inflammation ...
Olah, M +3 more
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Microglia, the tissue macrophages of the brain, have under healthy conditions a resting phenotype that is characterized by a ramified morphology. With their fine processes microglia are continuously scanning their environment. Upon any homeostatic disturbance microglia rapidly change their phenotype and contribute to processes including inflammation ...
Olah, M +3 more
openaire +3 more sources