Results 251 to 260 of about 235,228 (311)

Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

Microglia in Epilepsy: From Molecular Mechanism to Therapeutic Strategy. [PDF]

Cells
Paudel YN, Angelopoulou E, Kulkarni S, Blair RE, Deshpande LS.   +4 more
europepmc   +1 more source

A compendium of extracellular vesicle biogenesis inhibitors: From bench to bedside

Interdisciplinary Medicine, EarlyView.
This review explores a decade of research on extracellular vesicles (EVs), detailing their biogenesis and roles in health and disease. It emphasizes EVs' relevance for potential medical applications covering various conditions such as cancer, neurodegeneration, inflammation, and infectious diseases, bridging experimental findings with clinical ...
Stefano Vecchione, Ana Talamillo, Juan M. Falcón‐Pérez   +2 more
wiley   +1 more source

MIF-Induced CD74+ Microglia and Macrophages Promote Progression of Brain Metastasis and Are Clinically Relevant across Central Nervous System Disorders. [PDF]

Cancer Res
Alvaro-Espinosa L, Marquez-Galera A, Priego N, García-Calvo V, Perea-García M, Hernandez-Oliver C, Retana D, Sanchez O, de Pablos-Aragoneses A, García-Gómez P, Graña-Castro O, Lapuente-Santana Ó, Serrano-Ron L, Al-Shahrour F, Cayuela López A, Peset I, Megías D, Ola M, Varešlija D, Young LS, Martí-Mateos Y, Enríquez JA, Hernández-Encinas E, Blanco-Aparicio C, Soengas MS, Bernhagen J, Antón-Fernández A, Ávila J, Marchena MA, Torres M, de Castro F, Márquez-Ropero M, Sierra A, Lopez-Atalaya JP, RENACER Group, Valiente M.   +35 more
europepmc   +1 more source

Microbial metabolite indole‐3‐propionic acid preserves astrocytic mitochondrial mitofusin 2 to limit neuroinflammation after traumatic brain injury

Interdisciplinary Medicine, EarlyView.
Following traumatic brain injury, indole‐3‐propionic acid (IPA) directly targets the aryl hydrocarbon receptor on astrocytes in the peri‐lesional cortex; this suppresses interferon regulatory factor 1‐driven transcription of the E3 ubiquitin ligase RFFL (ring finger and FYVE‐like domain containing E3 ubiquitin protein ligase).
Ziwen Zhang, Kai Wang, Liangbo Wang, Wencong Li, Hao Guo, Meng Xu, Tinghao Wang, Jiahui Ren, Ting Zhu, Jiahui Wang, Wenxing Cui, Jinpeng Zhou, Yang Tian, Liying Han, Chengxuan Guo, Shuoyao Ma, Qiang Wang, Zhihong Li, Yaning Cai, Jingyu Dong, Xun Wu, Haixiao Liu, Yan Qu   +22 more
wiley   +1 more source

The mechanism of dynamic switching between M1/M2 phenotypes of microglia in neuropathic pain: a narrative review. [PDF]

Front Mol Neurosci
Mao Y, Xu L, Yao M.
europepmc   +1 more source

Bisphenol Analog‐Induced Cytotoxicity: Unraveling Endoplasmic Reticulum (ER) Stress and Apoptotic Pathways

Journal of Applied Toxicology, EarlyView.
ABSTRACT Bisphenol A (BPA) is increasingly replaced by structural analogs, yet their safety remains insufficiently characterized. This study investigated whether BPA and selected analogs, bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol P (BPP), and bisphenol E (BPE), induce cytotoxicity through activation of endoplasmic reticulum (ER) stress and ...
Rafia Afroze Rifa, Ramon Lavado
wiley   +1 more source

Targeting microglia-mediated neuroinflammation in Alzheimer's disease: mechanisms and therapeutic approaches. [PDF]

Front Immunol
Li BF, Chen XY, Xie R, Mo YF, Wu YZ, Meng Y, Han XL, Chen MH, Peng YJ.   +8 more
europepmc   +1 more source

Long-term polystyrene nanoplastics exposure aggravates retinal inflammation and photoreceptor degeneration through microglial SPP1 signaling and neutrophil extracellular traps formation. [PDF]

J Transl Med
Zhou W, Chen X, Li J, He J.
europepmc   +1 more source