Results 261 to 270 of about 249,102 (311)

Microglia and its P2RY12 receptors regulate seizure severity. [PDF]

iScience
Fremuth LE, Gibbs-Shelton S, Doceti M, Lopez-Ortiz AO, Duffy A, Mills WA, Gaykema RP, Singh K, Nguyen A, Cheng S, Perez-Reyes E, Eyo UB.   +11 more
europepmc   +1 more source

Anti-inflammatory CAR-microglia targeting Aβ for Alzheimer's disease therapy. [PDF]

Front Immunol
Ding X, Hu X, Xue W, An Y, Cheng W, Zhang S, Lei A, Zhang J.   +7 more
europepmc   +1 more source

KOLF2.1J iTF-Microglia: A standardized platform to study microglial transcriptional regulatory networks in CNS disease. [PDF]

iScience
Rogers BB, Anderson AG, Rodriguez-Nunez I, Bartley SC, Johnston SQ, Taylor JW, Meadows SK, Newberry KM, Myers RM, Cochran JN.   +9 more
europepmc   +1 more source

Microglia derived from human induced pluripotent stem cells are regulated by osteopontin, an endogenous extracellular matrix protein maintaining immune homeostasis. [PDF]

Front Neurosci
Olschewski DN, Koenig AM, Nerone HM, Gross E, Šarić T, Vay SU, Schroeter M, Fink GR, Rueger MA.   +8 more
europepmc   +1 more source

Ablation of microglial estrogen receptor alpha predisposes male mice to diet-induced obesity. [PDF]

Metabolism
Velasco I, Frey JM, Baglaev V, Jafari T, Huang T, Schwie S, Santiago OD, Fasnacht RD, Thaler JP, Dorfman MD.   +9 more
europepmc   +1 more source

Nutritional substrates and microglial metabolic fitness in brain aging and Alzheimer's disease: from lipid handling to TREM2-linked translation. [PDF]

Front Nutr
Li Z, Ming Q, Fu L, Yang J, Lv Y, Chen B, Lu Z.   +6 more
europepmc   +1 more source

Single-cell discovery of mTOR-associated microglial clusters in human mTORopathies

Kalf RS, Scheper M, Horst EET, Anink JJ, Jansen FE, Hecke Wv, Mühlebner A, Vliet EAv, Mills JD, Aronica E.   +9 more
europepmc   +1 more source

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Physiology of Microglia

2019
Microglial cells derive from fetal macrophages which immigrate into and disseminate throughout the central nervous system (CNS) in early embryogenesis. After settling in the nerve tissue, microglial progenitors acquire an idiosyncratic morphological phenotype with small cell body and moving thin and highly ramified processes currently defined as ...
Garaschuk, Olga, Verkhratsky, Alexei
openaire   +7 more sources

Plasticity of microglia

Biological Reviews, 2021
ABSTRACTMicroglial cells are the scions of foetal macrophages which invade the neural tube early during embryogenesis. The nervous tissue environment instigates the phenotypic metamorphosis of foetal macrophages into idiosyncratic surveilling microglia, which are generally characterised by a small cell body and highly ramified motile processes that ...
Marcus Augusto‐Oliveira, Gabriela P. Arrifano, Charlotte Isabelle Delage, Marie‐Ève Tremblay, Maria Elena Crespo‐Lopez, Alexei Verkhratsky   +5 more
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Origin of microglia

Microscopy Research and Technique, 2001
AbstractThis paper reviews the various proposed hypotheses on the origin of microglia. The seminal study of del Rio‐Hortega first stated that the cells were derived from the mesodermal pial cells that invaded the brain during embryonic development. Along with this was the description of precursor cells in the yolk sac in early development.
Kaur, C., Hao, A.-J., Ling, E.-A., Wu, C.-H.   +3 more
openaire   +2 more sources