Results 31 to 40 of about 51,233 (376)

Regulation of the NRG1/ErbB4 Pathway in the Intrinsic Cardiac Nervous System Is a Potential Treatment for Atrial Fibrillation

Frontiers in Physiology, 2018
Background: The NRG1/ErbB4 signaling mechanism has been widely studied in the central nervous system for many years. However, the role of this pathway in modulating the intrinsic cardiac nervous system is largely unknown.Objective: The present study ...
Xiaoya Zhou, Zhuo Wang, Bing Huang, Shenxu Yuan, Xia Sheng, Lilei Yu, Guannan Meng, Yuhong Wang, Sunny S. Po, Hong Jiang   +9 more
doaj   +1 more source

Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration

Scientific Reports, 2021
Zebrafish (Danio rerio) is increasingly used to assess the pharmacological activity and toxicity of compounds. The spatiotemporal distribution of seven fluorescent alkyne compounds was examined during 48 h after immersion (10 µM) or microinjection (2 mg ...
Marlly Guarin, Ruben Faelens, Arianna Giusti, Noémie De Croze, Marc Léonard, Deirdre Cabooter, Pieter Annaert, Peter de Witte, Annelii Ny   +8 more
doaj   +1 more source

D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting

Brain Sciences, 2023
Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the
Zhi-Yue Gao, Chung Ming Huang, Cai-N Cheng, Andrew Chih-Wei Huang   +3 more
doaj   +1 more source

A randomized, open-label, comparative study of oral tranexamic acid and tranexamic acid microinjections in patients with melasma.

Indian Journal of Dermatology, Venereology and Leprology, 2019
Background Melasma poses a great challenge as its treatment modalities are unsatisfactory. Treatment using tranexamic acid is a novel concept. Aim This study aimed to compare the therapeutic efficacy and safety of oral tranexamic acid and tranexamic ...
V. Khurana, R. Misri, Swati Agarwal, A. Thole, Sachin Kumar, T. Anand   +5 more
semanticscholar   +1 more source

The effect of combined glutamate receptor blockade in the NTS on the hypoxic ventilatory response in awake rats differs from the effect of individual glutamate receptor blockade. [PDF]

, 2014
Ventilatory acclimatization to hypoxia (VAH) increases the hypoxic ventilatory response (HVR) and causes persistent hyperventilation when normoxia is restored, which is consistent with the occurrence of synaptic plasticity in acclimatized animals ...
Carr, John A, Nguyen, Jetson, Pamenter, Matthew E, Powell, Frank L   +3 more
core   +2 more sources

mGluR5 antagonism inhibits cocaine reinforcement and relapse by elevation of extracellular glutamate in the nucleus accumbens via a CB1 receptor mechanism. [PDF]

, 2018
Metabotropic glutamate receptor 5 (mGluR5) antagonism inhibits cocaine self-administration and reinstatement of drug-seeking behavior. However, the cellular and molecular mechanisms underlying this action are poorly understood.
Bi, Guo-Hua, Gardner, Eliot L, He, Yi, Jordan, Chloe J, Li, Jie, Li, Xia, Peng, Xiao-Qing, Xi, Zheng-Xiong, Yang, Hong-Ju, Zhang, Hai-Ying   +9 more
core   +2 more sources

Involvement of orexin type-2 receptors in genetic absence epilepsy rats

Frontiers in Neurology, 2023
IntroductionOrexin is a neuropeptide neurotransmitter that regulates the sleep/wake cycle produced by the lateral hypothalamus neurons. Recent studies have shown the involvement of orexin system in epilepsy.
Aylin Toplu, Aylin Toplu, Nursima Mutlu, Elif Tuğçe Erdeve, Özge Sariyildiz, Musa Çelik, Devrim Öz-Arslan, Devrim Öz-Arslan, Devrim Öz-Arslan, Özlem Akman, Zoltan Molnár, Nihan Çarçak, Nihan Çarçak, Filiz Onat, Filiz Onat   +14 more
doaj   +1 more source

MMS/FEEPS Observations of Electron Microinjections Due to Kelvin‐Helmholtz Waves and Flux Transfer Events: A Case Study

Journal of Geophysical Research: Space Physics, 2018
The Energetic Particle Detector (EPD) suite onboard the Magnetospheric Multiscale (MMS) spacecraft observes dispersive and repetitive fluxes of high‐energy (50–400 keV) electrons within the Pc5 frequency band (2–8 MHz) in the dusk to midnight region of ...
S. Kavosi, H. Spence, J. Fennell, D. Turner, H. Connor, J. Raeder   +5 more
semanticscholar   +1 more source

Effects of intra-accumbal or intra-prefrontal cortex microinjections of adenosine 2A receptor ligands on responses to cocaine reward and seeking in rats

Psychopharmacology, 2018
Many studies indicated that adenosine via its A2A receptors influences the behavioral effects of cocaine by modulating dopamine neurotransmission. The hypothesis was tested that A2A receptors in the nucleus accumbens (NAc) or the prefrontral cortex (PFc)
K. Wydra, A. Suder, M. Frankowska, D. O. B. Escuela, K. Fuxe, M. Filip   +5 more
semanticscholar   +1 more source

Melanin-Concentrating Hormone (MCH): Role in REM Sleep and Depression. [PDF]

, 2015
The melanin-concentrating hormone (MCH) is a peptidergic neuromodulator synthesized by neurons of the lateral sector of the posterior hypothalamus and zona incerta.
Benedetto, Luciana, Chase, Michael H, Lagos, Patricia, López-Hill, Ximena, Monti, Jaime M, Pascovich, Claudia, Scorza, Cecilia, Torterolo, Pablo, Urbanavicius, Jessika   +8 more
core   +3 more sources