Results 21 to 30 of about 15,619 (228)

Spatiotemporal imaging and pharmacokinetics of fluorescent compounds in zebrafish eleuthero-embryos after different routes of administration

Scientific Reports, 2021
Zebrafish (Danio rerio) is increasingly used to assess the pharmacological activity and toxicity of compounds. The spatiotemporal distribution of seven fluorescent alkyne compounds was examined during 48 h after immersion (10 µM) or microinjection (2 mg ...
Marlly Guarin, Ruben Faelens, Arianna Giusti, Noémie De Croze, Marc Léonard, Deirdre Cabooter, Pieter Annaert, Peter de Witte, Annelii Ny   +8 more
doaj   +1 more source

D2 Receptors and Sodium Ion Channel Blockades of the Basolateral Amygdala Attenuate Lithium Chloride-Induced Conditioned Taste Aversion Applying to Cancer Chemotherapy Nausea and Vomiting

Brain Sciences, 2023
Cancer patients regularly suffer from the behavioral symptoms of chemotherapy-induced nausea and vomiting. Particularly, it is involved in Pavlovian conditioning. Lithium chloride (LiCl) was used as the unconditioned stimulus (US) and contingent with the
Zhi-Yue Gao, Chung Ming Huang, Cai-N Cheng, Andrew Chih-Wei Huang   +3 more
doaj   +1 more source

Involvement of orexin type-2 receptors in genetic absence epilepsy rats

Frontiers in Neurology, 2023
IntroductionOrexin is a neuropeptide neurotransmitter that regulates the sleep/wake cycle produced by the lateral hypothalamus neurons. Recent studies have shown the involvement of orexin system in epilepsy.
Aylin Toplu, Aylin Toplu, Nursima Mutlu, Elif Tuğçe Erdeve, Özge Sariyildiz, Musa Çelik, Devrim Öz-Arslan, Devrim Öz-Arslan, Devrim Öz-Arslan, Özlem Akman, Zoltan Molnár, Nihan Çarçak, Nihan Çarçak, Filiz Onat, Filiz Onat   +14 more
doaj   +1 more source

Pituitary Adenylate-Cyclase Activating Polypeptide Regulates Hunger- and Palatability-Induced Binge Eating

Frontiers in Neuroscience, 2016
While pituitary adenylate cyclase activating polypeptide (PACAP) signaling in the hypothalamic ventromedial nuclei (VMN) has been shown to regulate feeding, a challenge in unmasking a role for this peptide in obesity is that excess feeding can involve ...
Matthew M. Hurley, Brian Maunze, Megan E. Block, Mogen M. Frenkel, Michael J. Reilly, Eugene Kim, Yao Chen, Yan Li, David A. Baker, Qing-Song Liu, SuJean Choi   +10 more
doaj   +1 more source

Antinociceptive Effect of Morphine Microinjections into the Dorsal Hippocampus in the Formalin-Induced Orofacial Pain in Rats [PDF]

Veterinary Research Forum, 2010
In the present study, the effects of intra-hippocampal microinjections of morphine (an opioid agonist) and naloxone (an opioid antagonist) were investigated in the formalin-induced orofacial pain in rats.
Emad Khalilzadeh, Amir Abbas Farshid, Esmaeal Tamaddonfard, Amir Erfanparast   +3 more
doaj  

Effect of platelet-rich plasma microinjections on the healing and histostructure of extended fasciocutaneous flaps based on axial blood supply

Гений oртопедии, 2018
Purpose To reveal a possible effect of platelet-rich plasma (PRP) on healing and histostructure of extended fasciocutaneous flaps with axial blood supply Materials and methods A flap based on the superficial inferior epigastric artery (SIEA) and extended
Natal'ia A. Shchudlo, Tat'iana N. Varsegova, Liudmila I. Sbrodova, Mikhail M. Shchudlo   +3 more
doaj   +1 more source

Modulation of the cough reflex by GABAA receptors in the caudal ventral respiratory group of the rabbit

Frontiers in Physiology, 2012
We have previously shown that the caudal ventral respiratory group (cVRG) is a possible site of action of some antitussive drugs and plays a crucial role in determining both the expiratory and inspiratory components of the cough motor pattern.
Elenia eCinelli, Fulvia eBongianni, Tito ePantaleo, Donatella eMutolo   +3 more
doaj   +1 more source

Optical Imaging-Based Guidance of Viral Microinjections and Insertion of a Laminar Electrophysiology Probe Into a Predetermined Barrel in Mouse Area S1BF

Frontiers in Neural Circuits, 2021
Wide-field Optical Imaging of Intrinsic Signals (OI-IS; Grinvald et al., 1986) is a method for imaging functional brain hemodynamic responses, mainly used to image activity from the surface of the cerebral cortex.
Victor M. Mocanu, Victor M. Mocanu, Amir Shmuel, Amir Shmuel, Amir Shmuel, Amir Shmuel   +5 more
doaj   +1 more source

Nucleus accumbens corticotropin-releasing factor increases cue-triggered motivation for sucrose reward: paradoxical positive incentive effects in stress?

BMC Biology, 2006
Background Corticotropin-releasing factor (CRF) is typically considered to mediate aversive aspects of stress, fear and anxiety. However, CRF release in the brain is also elicited by natural rewards and incentive cues, raising the possibility that some ...
Schulkin Jay, Peciña Susana, Berridge Kent C   +2 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source