3D-printed barbed microneedle electrodes for biosensing and drug delivery in wound management. [PDF]
Fu X +8 more
europepmc +1 more source
ABSTRACT Electroporation‐based biopsy (e‐biopsy) enables minimally invasive extraction of tissue proteins without excision; however, the effective diffusion from tissue into the sampling medium, a key parameter required for this procedure, has not been quantified in human tissues. We coupled time‐resolved aqueous sampling with a one‐dimensional Fickian
Amir Duenyas +6 more
wiley +1 more source
Composing drug delivery with light distribution improvement: the use of dissolving microneedles in skin cancer with photodynamic therapy. [PDF]
Requena MB +4 more
europepmc +1 more source
Ferroptosis in breast cancer: From adipocyte–immune–iron regulation to therapeutic application
Ferroptosis in breast cancer is regulated by an integrated adipocyte–immune–iron network rather than by tumour‐intrinsic pathways alone. Adipocyte‐derived lipid substrates and redox metabolites, immune‐cell‐mediated cytokine signalling and iron‐dependent oxidative stress collectively shape a dynamic ferroptosis ecosystem that can shift tumours towards ...
Juan Sun, Yang Qu, Ru Yao, Yidong Zhou
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Comprehensive chemical, morphological, thermal, and biological characterization of Agave tequilana extract and chitosan-based dissolving microneedle arrays. [PDF]
Quintero-Rincón P +2 more
europepmc +1 more source
Schematic illustration of the development, optimization, and therapeutic evaluation of the Leucas aspera phytosome‐based thermogel for topical antipsoriatic therapy, highlighting its enhanced solubility, skin deposition, and in vivo efficacy in an imiquimod‐induced psoriasis model. Created with BioRender.com.
Ananda Kumar Chettupalli +2 more
wiley +1 more source
3D-Printed Microneedle Patch for the Treatment of Melanoma via Synergistic Chemotherapy and Photothermal Therapy. [PDF]
Yilmaz H +10 more
europepmc +1 more source
Innovative Drug Delivery Systems for the Treatment of Glaucoma
This review aims to provide a comprehensive overview of current topical drug delivery strategies for ocular hypotensive agents in glaucoma therapy. Additionally, it discusses the potential impact of emerging nanotechnological and biomaterial‐based systems in shaping the future of ophthalmic drug delivery, with an emphasis on enhancing efficacy, safety,
Jing Chu +9 more
wiley +1 more source
A programmable bioresorbable electrochemical microneedle sensor array for perioperative monitoring of organ health. [PDF]
Li X +9 more
europepmc +1 more source
Diabetic Peripheral Neuropathy: Molecular Staging, Risk Factors, Therapeutics, and Emerging Trends
The heterogeneous landscape of DPN can be unified through a tripartite pathogenic model encompassing progressive stages of metabolic dysregulation, chronic inflammation, and overt neuronal damage. Within this framework, six clinical subtypes were identified, namely, hyperglycemia‐driven, dyslipidemia‐driven, inflammation‐driven, dysvascularity‐driven ...
Xiaofeng Dai, Mingze Tang
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