Results 321 to 330 of about 745,929 (388)

A Refined Adaptive Laboratory Evolution Strategy With Biosensor‐Assisted Selection Resolves the Tolerance–Efficiency Trade‐Off in Toxic Chemical Biosynthesis

open access: yesAdvanced Science, EarlyView.
This study presents a refined adaptive laboratory evolution (ALE) strategy to resolve the trade‐off between tolerance and biosynthetic efficiency in toxic chemical production. Combining in vivo mutagenesis, microdroplet‐based evolution, and biosensor‐assisted selection, this strategy rapidly yields robust “win‐win” phenotypes.
Yufei Zhang   +7 more
wiley   +1 more source

Solvent‐Rich Pre‐Coagulation Bath for Tunable Liquid‐State Fusion Enables Robust Two‐Step Polymer Embedded Printing

open access: yesAdvanced Science, EarlyView.
Additive manufacturing enables complex structures, but polymer printing often suffers from poor interlayer fusion and defects induced by heat or binders. A two‐step, room‐temperature strategy based on immersion phase separation (IPS‐E3DP) achieves precise liquid‐state fusion with high structural fidelity, enhanced mechanical performance, broad material
Kaidong Song   +11 more
wiley   +1 more source

Smart Gated Hollow Mesoporous Silica Hydrogel for Targeting Endoplasmic Reticulum Stress and Promoting Periodontal Tissue Regeneration

open access: yesAdvanced Science, EarlyView.
The hollow mesoporous silica loaded with quercetin (HM‐QU@PEG) is combined with a thermosensitive anti‐bacterial matrix (TF127) to prepare HQUP@TF127. HQUP@TF127 effectively eliminates excessive ROS, alleviates endoplasmic reticulum stress, relieves mitochondrial calcium overload, and blocks the p53‐dependent apoptotic cascade. Furthermore, it enhances
Guichun Wang   +14 more
wiley   +1 more source

Hyperspectral Imaging Techniques for Lyophilization: Advances in Data‐Driven Modeling Strategies and Applications

open access: yesAdvanced Science, EarlyView.
Lyophilization is a key process used in the production of biotherapeutic products. This article reviews and discusses the application of HSI on lyophilization, and the strategies that use the resulting data to build models. It is intended to provide guidance and insights for non‐specialist researchers and engineers into leveraging HSI and the data ...
Huiwen Yu   +5 more
wiley   +1 more source

Engineering Separated Dual O2 Reduction Cores into One Polymer Framework for Boosting Hydrogen Peroxide Production

open access: yesAdvanced Science, EarlyView.
Here the rational design of two O2 reduction cores into one polymer framework is showcased for synergistically facilitating H2O2 production via the “selfmarketing & cooperation” strategy. Photoactive units of pyrrolo[3,2‐b]pyrrole and porphyrin are successfully settled in covalent organic polymers (COPs) through polycyclizations of the relevant ...
Mengmeng Fu   +9 more
wiley   +1 more source

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