Results 141 to 150 of about 6,641 (226)

BLOC: Buildable and Linkable Organ on a Chip

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
We developed a “Buildable and Linkable Organ on a Chip” (BLOC) that can construct diverse microphysiological systems (MPSs). The BLOC is standardized to the same size and has one of the functions of “Culture,” “Control,” or “Analysis.” Users can freely configure various MPSs, including developing perfusion, cytotoxicity analysis, and biochemical ...
Yusuke Kimura, Hiroki Hamaguchi, Kotaro Oyama, Tomoko G. Oyama, Atsushi Kimura, Yasuhiro Ohshima, Noriko S. Ishioka, Mitsumasa Taguchi   +7 more
wiley   +1 more source

Estradiol and dihydrotestosterone exert sex-specific effects on human fibroblast and endothelial proliferation, bioenergetics, and vasculogenesis

Communications Biology
Sex-specific cell culture methods and microphysiological systems can enhance our understanding of how biological sex influences health and disease. Here, we investigated the effects of estradiol and dihydrotestosterone on primary human lung and ocular ...
Ashley T. Martier, Yasmin V. Maurice, K. Michael Conrad, Delia A. Carlino, Franck Mauvais-Jarvis, Mark J. Mondrinos   +5 more
doaj   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Rescue of impaired blood-brain barrier in tuberous sclerosis complex patient derived neurovascular unit

Journal of Neurodevelopmental Disorders
Background Tuberous sclerosis complex (TSC) is a multi-system genetic disease that causes benign tumors in the brain and other vital organs. The most debilitating symptoms result from involvement of the central nervous system and lead to a multitude of ...
Jacquelyn A. Brown, Shannon L. Faley, Monika Judge, Patricia Ward, Rebecca A. Ihrie, Robert Carson, Laura Armstrong, Mustafa Sahin, John P. Wikswo, Kevin C. Ess, M. Diana Neely   +10 more
doaj   +1 more source

Tumor‐Immune‐On‐Chip to Evaluate Pathophysiological Feature of T Lymphocytes Expanded from Patient Tumors and Lymph Node Tissues

Cancer Medicine, Volume 15, Issue 5, May 2026.
3D Tumor‐Immune On‐Chip reveals patient‐derived tumor‐infiltrating lymphocytes (TILs) exhibit superior infiltration and cytotoxicity against colorectal cancer spheroids compared to lymph node T cells, providing a platform to study patient‐specific tumor‐immune interactions for developing personalized cancer immunotherapies.
Gyu‐Bon Cho, Hyun‐Joo Lee, You Jeong Heo, Jihoon Ko, Won‐Suk Lee, Sujin Hyung   +5 more
wiley   +1 more source

An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery

Microsystems & Nanoengineering
Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support ...
Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo   +8 more
doaj   +1 more source

A modified lethal–potentially lethal model for oxygen‐mediated FLASH sparing in stem cell niches

Medical Physics, Volume 53, Issue 5, May 2026.
Abstract Background Ultra‐high dose rate (FLASH) irradiation can reduce normal‐tissue toxicity while preserving tumor control, but a mechanistic explanation consistent with classical radiobiology remains incomplete. In particular, oxygen‐depletion arguments based solely on bulk tissue oxygenation can appear inconsistent with clinically relevant ...
Sumin Zhou
wiley   +1 more source

Enteric Nervous System Damage by Food Contaminants: A Pathway to Neurodegeneration?

Comprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT The enteric nervous system (ENS), a key component of the gut–brain axis, has emerged as a critical player in the pathogenesis of Parkinson's disease (PD). It is the first neural system exposed to food contaminants (FCs)—a diverse group of ubiquitous toxic compounds fortuitously present in food derived from production, processing, storage, or ...
Helena Ramos, Ana Margarida Araújo, Isabel M. P. L. V. O. Ferreira, Miguel A. Faria   +3 more
wiley   +1 more source

Aerospace medicine and biology: A continuing bibliography with indexes, supplement 130, July 1974 [PDF]

This special bibliography lists 291 reports, articles, and other documents introduced into the NASA scientific and technical information system in June ...

core   +1 more source

Moving lab-grown tissues into the clinic: organ-on-a-chip and bioengineered skin systems

Frontiers in Lab on a Chip Technologies
For patients with end stage organ failure, organ transplant is frequently the only curative option available. However, organs available for transplant are in critically short supply around the world, which has led to lengthy wait times and increased ...
Catherine A. Reed-McBain, Catherine A. Reed-McBain, Janmesh D. Patel, Finnbar L. K. Reed-McBain, David Al-Adra, María Virumbrales-Muñoz, María Virumbrales-Muñoz, María Virumbrales-Muñoz, Jose M. Ayuso, Jose M. Ayuso, Jose M. Ayuso   +10 more
doaj   +1 more source