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Microphysiological systems: What it takes for community adoption
Experimental Biology and Medicine, 2021 Microphysiological systems (MPS) are promising in vitro tools which could substantially improve the drug development process, particularly for underserved patient populations such as those with rare diseases, neural disorders, and diseases impacting pediatric populations.
Passley Hargrove-Grimes +2 more
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Microphysiological systems of the placental barrier
Advanced Drug Delivery Reviews, 2020Methods to evaluate maternal-fetal transport across the placental barrier have generally involved clinical observations after-the-fact, ex vivo perfused placenta studies, or in vitro Transwell assays. Given the ethical and technical limitations in these approaches, and the drive to understand fetal development through the lens of transport-induced ...
Navein, Arumugasaamy +4 more
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Integrated biosensors for monitoring microphysiological systems
Lab on a Chip, 2022This review discusses the state-of-the-art integrated biosensors by providing specific examples, detailing their main advantages in monitoring MPSs, and describing the remaining challenges and potential future developments.
Lei Mou +10 more
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Microphysiological Systems for Cancer Immunotherapy Research and Development
Advanced Biology, 2023AbstractCancer immunotherapy focuses on the use of patients’ adaptive immune systems to combat cancer. In the past decade, FDA has approved many immunotherapy products for cancer patients who suffer from primary tumors, tumor relapse, and metastases. However, these immunotherapies still show resistance in many patients and often lead to inconsistent ...
Yansong Peng, Esak Lee
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Human microphysiological systems for drug development
Science, 2021Organs-on-chips could be used to assess drug efficacy and support personalized ...
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Microfluidic-based vascularized microphysiological systems
Lab on a Chip, 2018Microphysiological systems have emerged in the last decade to provide an alternative to in vivo models in basic science and pharmaceutical research.
Somin Lee +6 more
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Developing Liver Microphysiological Systems for Biomedical Applications
Advanced Healthcare Materials, 2023AbstractMicrophysiological systems (MPSs), also known as organ chips, are micro‐units that integrate cells with diverse physical and biochemical environmental cues. In the field of liver MPSs, cellular components have advanced from simple planar cell cultures to more sophisticated 3D formations such as spheroids and organoids. Additionally, progress in
Jinglin Wang +4 more
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Vascular microphysiological systems
Current Opinion in HematologyPurpose of review This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works. Recent findings Vascular MPS are increasing in complexity and ability to replicate tissue.
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Application of microphysiological systems in biopharmaceutical research and development
Lab on a Chip, 2020In this review, we describe some of the advances made for tissue-specific microphysiological systems and outline the advantages and challenges of applying and further developing MPS technology in preclinical biopharmaceutical research.
Norman C. Peterson +3 more
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Microphysiological systems inspired by leaf venation
Trends in BiotechnologyNature-inspired microfluidic networks are revolutionizing microphysiological systems, allowing for the precise emulation of human physiology. This article delves into the fabrication techniques of leaf-venation-inspired (LVI) microfluidic networks and explores their transformative applications in organ-on-a-chip and tissue engineering, showcasing their
Mao Mao +3 more
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