Results 111 to 120 of about 498,599 (357)

The microRNA miR-202 prevents precocious spermatogonial differentiation and meiotic initiation during mouse spermatogenesis [PDF]

, 2021
Jian Chen, Chenxu Gao, Xiwen Lin, Yan Ning, Wei He, Chunwei Zheng, Daoqin Zhang, Lin Yan, Binjie Jiang, Yuting Zhao, Md. Alim Hossen, Chunsheng Han   +11 more
openalex   +1 more source

MicroRNA immunobiology: when microRNA chemists meet immunologists [PDF]

Cellular & Molecular Immunology, 2011
Although interdisciplinary research has been heralded as the engine of basic discovery for decades, many in the immunology community have been taken back by the recent marriage between microRNA (miRNA) and immunology. MicroRNAs were first discovered by Ambros and colleagues in 1993.1 They are small untranslated RNAs, highly conserved between different ...
openaire   +2 more sources

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Functional Characteristics of Gene Expression Motifs with Single and Dual Strategies of Regulation

, 2016
Transcriptional regulation by transcription factors and post-transcriptional regulation by microRNAs constitute two major modes of regulation of gene expression.
Bose, Indrani, Ghosh, Sayantari, Pal, Mainak   +2 more
core   +1 more source

Apolipoprotein E and Atherosclerosis: From Lipoprotein Metabolism to MicroRNA Control of Inflammation. [PDF]

, 2018
Apolipoprotein (apo) E stands out among plasma apolipoproteins through its unprecedented ability to protect against atherosclerosis. Although best recognized for its ability to mediate plasma lipoprotein clearance in the liver and protect against ...
Hasty, Hui, Hussain, Lin, Mahley, Pepe, Roselaar   +6 more
core   +2 more sources

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

Protecting and rejuvenating ageing skin by regulating endogenous hyaluronan metabolism using adipose-derived stem cell-secreted siRNAs

Frontiers in Medicine
BackgroundLoss of moisture is the primary cause of skin ageing and dysfunction. The skin’s hydration largely depends on hyaluronan (HA) and its ability to retain water.
Benben Sun, Yanqiu He, Lingzhu Zhang, Siyu Liu, Menghan Chen, Jinmeng Pan, Jingwen Fang, Ye Wang, Haiyue Jiang, Xia Liu, Chen-Yu Zhang, Chen-Yu Zhang, Chen-Yu Zhang, Jing Li, Jing Li   +14 more
doaj   +1 more source

MicroRNA-125b-5p mimic inhibits acute liver failure

Nature Communications, 2016
miR125b-5p has been associated with acute liver failure. Here the authors show that this miRNA targets Keap1 and activates Nrf2 to inhibit liver cell death after APAP or FAS toxicity, plus they show that a miR125b-5p mimic can inhibit ALF in mice.
Dakai Yang, Qinggong Yuan, Asha Balakrishnan, Heike Bantel, Jan-Henning Klusmann, Michael P. Manns, Michael Ott, Tobias Cantz, Amar Deep Sharma   +8 more
doaj   +1 more source

TranspoGene and microTranspoGene: transposed elements influence on the transcriptome of seven vertebrates and invertebrates [PDF]

, 2008
Transposed elements (TEs) are mobile genetic sequences. During the evolution of eukaryotes TEs were inserted into active protein-coding genes, affecting gene structure, expression and splicing patterns, and protein sequences.
Asaf Levy, Biemont, Borchert, Callinan, Clark, Consortium, Dagan, Deininger, Deininger, Gasteiger, Giardine, Gil Ast, Griffiths-Jones, Han, Hedges, Houwing, Johnson, Jordan, Jurka, Karolchik, Kent, Kim, Kim, Kuhn, Lander, Lev-Maor, Lippman, Lorenc, Makalowski, Martignetti, McKusick, Morgan, Noa Sela, Pasyukova, Piriyapongsa, Pruitt, Sayah, Sela, Smalheiser, Smalheiser, Sorek, Sorek, Thornburg, Waterston   +43 more
core   +3 more sources