Results 101 to 110 of about 505,053 (355)
FEBS Open Bio, EarlyView.In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara +3 more
wiley +1 more source
Special recipe from pollens for the caste determination of honeybees
ExRNA, 2019 Honeybee caste differentiation is regulated by multiple factors. Here we comment an article published on August 31, 2017, Plos Genetics, which show that miRNAs from pollen may affect honeybee caste formation.
Bo Sun
doaj +1 more source
In-Plant Insect-Proofing by Trans-Kingdom RNAi
Proceedings, 2020 Helicoverpa armigera, the cotton bollworm, is a major insect pest for a wide range of agriculturalcrops. [...]
Julia Bally +5 more
doaj +1 more source
An introspective update on the influence of miRNAs in breast carcinoma and neuroblastoma chemoresistance [PDF]
, 2014 Chemoresistance to conventional cytotoxic drugsmay occur in any type of cancer and this can either be inherent or develop through time. Studies have linked this acquired resistance to the abnormal expression of microRNAs (miRNAs) that normally silence ...
Ayers, Duncan +2 more
core +4 more sources
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Long noncoding RNAs in renal diseases
ExRNA, 2019 Long noncoding RNAs (lncRNAs) play critical roles in eukaryotic gene regulation and diseases, rather than being merely transcriptional “noise”. Over the past decade, the study of lncRNAs has emerged as a burgeoning field of research and expanded our ...
Minghui Liu, Jie Ren
doaj +1 more source
The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling [PDF]
, 2018 Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease
Antonelli, Manila +19 more
core +1 more source
MicroRNA immunobiology: when microRNA chemists meet immunologists [PDF]
Cellular & Molecular Immunology, 2011 Although interdisciplinary research has been heralded as the engine of basic discovery for decades, many in the immunology community have been taken back by the recent marriage between microRNA (miRNA) and immunology. MicroRNAs were first discovered by Ambros and colleagues in 1993.1 They are small untranslated RNAs, highly conserved between different ...
openaire +2 more sources
Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling
Advanced Healthcare Materials, EarlyView.Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee +7 more
wiley +1 more source
The interplay between viral-derived miRNAs and host immunity during infection [PDF]
, 2019 MicroRNAs are short non-coding RNAs that play a crucial role in the regulation of gene expression during cellular processes. The host-encoded miRNAs are known to modulate the antiviral defense during viral infection.
Ingle, Harshad +3 more
core +1 more source