Results 131 to 140 of about 642,362 (390)

Synthetic Strategy for mRNA Encapsulation and Gene Delivery with Nanoscale Metal‐Organic Frameworks

Advanced Functional Materials, EarlyView.
This research utilizes the ZIF‐8 for the encapsulation and intracellular delivery of nucleic acids, specifically mRNA, for applications in gene delivery. Integrating PEI addresses the issue of mRNA leakage from ZIF‐8, resulting in the delivery and expression of green fluorescent protein (GFP) in vitro and firefly luciferase in vivo.
Harrison Douglas Lawson, Huy Hoang Nguyen, Keng‐Jung Lee, Nattarat Wongsuwan, Ayesha Tupe, Mengrou Lu, Mariah Lynn Arral, Anne Behre, Zihan Ling, Kathryn Ann Whitehead, Adam Walter Feinberg, Xi Ren, Si‐Yang Zheng   +12 more
wiley   +1 more source

MicroRNA-155—at the critical interface of innate and adaptive immunity in arthritis [PDF]

, 2018
MicroRNAs (miRNAs) are small non-coding RNAs that fine-tune the cell response to a changing environment by modulating the cell transcriptome. MiR-155 is a multifunctional miRNA enriched in cells of the immune system and is indispensable for the immune ...
Barbara Tolusso, Charles McSharry, Elisa Gremese, Gianfranco Ferraccioli, Iain B. McInnes, Iain B. McInnes, Mariola Kurowska-Stolarska, Mariola Kurowska-Stolarska, Stefano Alivernini   +8 more
core   +2 more sources

Bioengineering Strategies for Treating Neointimal Hyperplasia in Peripheral Vasculature: Innovations and Challenges

Advanced Healthcare Materials, Volume 14, Issue 7, March 14, 2025.
This review highlights emerging bioengineering strategies for treating neointimal hyperplasia in the peripheral vasculature, focusing on approaches that promote re‐endothelialization, modulate smooth muscle cell phenotype, reduce inflammation, mitigate oxidative stress, and optimize biomechanical compliance.
Nikita Wilson John, Caitlyn Dang, Nidhi Reddy, Calvin Chao, Karen J. Ho, Bin Jiang   +5 more
wiley   +1 more source

LncRNA CASC2 Alleviates the Progression of Diabetic Nephropathy by Regulating the miR-144/SOCS2 Signalling Axis

Kidney & Blood Pressure Research, 2020
Background: Diabetic nephropathy constitutes a large proportion of end-stage kidney failure in diabetic patients. However, the underlying molecular mechanisms remain unclear.
Xiao-Qiang Min, Yan Xie
doaj   +1 more source

HMDD v3.0: a database for experimentally supported human microRNA–disease associations

Nucleic Acids Res., 2018
Comprehensive databases of microRNA–disease associations are continuously demanded in biomedical researches. The recently launched version 3.0 of Human MicroRNA Disease Database (HMDD v3.0) manually collects a significant number of miRNA–disease ...
Zhou Huang, Jiangcheng Shi, Yuanxu Gao, Chunmei Cui, Shan Zhang, Jianwei Li, Yuan Zhou, Qinghua Cui   +7 more
semanticscholar   +1 more source

The copper microRNAs [PDF]

New Phytologist, 2016
SummaryCopper (Cu) microRNAs are upregulated by Cu deficiency and mediate the post‐transcriptional downregulation of transcripts that encode Cu proteins, suggesting a role directly related to Cu. However, expression and phenotypic analyses of copper microRNA mutants and over‐expressors have suggested roles mainly in tolerance to abiotic stresses.
openaire   +3 more sources

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J., El-Seed, Hesham, Ismail, Amin, Lai, Shanshan, Liu, Dan, Wu, Desheng, Xiao, Jianbo, Zhao, Chao, Zou, Xiaobo   +8 more
core   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source

Specific requirements of MRFs for the expression of muscle specific microRNAs, miR-1, miR-206 and miR-133 [PDF]

, 2008
The expression of three microRNAs, miR-1, miR-206 and miR-133 is restricted to skeletal myoblasts and cardiac tissue during embryo development and muscle cell differentiation, which suggests a regulation by muscle regulatory factors (MRFs).
Anderson, Andrea Münsterberg, Bennett, Braun, Buckingham, Callis, Carvajal, Carvajal, Chen, Chen, Dalmay, Darnell, de Alvaro, Delfini, Dylan Sweetman, Eisenberg, Gayraud-Morel, Gensch, Groom, Haldar, Hamburger, Harfe, Harris, He, Hornstein, Kassar-Duchossoy, Katarzyna Goljanek, Kim, Kontaridis, Kuwahara, Lai, Liu, Lluis, Maroto, McCarthy, McCarthy, McCarthy, O'Rourke, Olwin, Pena, Perry, Portier, Rao, Rawls, Rosenberg, Rudnicki, Rudnicki, Sebolt-Leopold, Smith, Svetlana Oustanina, Sweetman, Tajbakhsh, Tamas Dalmay, Tapscott, Thomas Braun, Tina Rathjen, Ustanina, van Rooij, Wienholds, Xiao, Yue, Zhang   +61 more
core   +1 more source

Aging on Chip: Harnessing the Potential of Microfluidic Technologies in Aging and Rejuvenation Research

Advanced Healthcare Materials, EarlyView.
This review highlights recent advances in microfluidic technologies for modeling human aging and age‐related diseases. It explores how organ‐on‐chip platforms improve physiological relevance, enable rejuvenation strategies, facilitate drug screening, detect senescent cells, and identify biomarkers.
Limor Zwi‐Dantsis, Vignesh Jayarajan, George M. Church, Roger D. Kamm, João Pedro de Magalhães, Emad Moeendarbary   +5 more
wiley   +1 more source