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Rewriting Cardiovascular Disease: Are MicroRNAs the Next Frontier? [PDF]
Nepal J EpidemiolBanerjee I +4 more
europepmc +1 more source
Are RNA Therapies a Solid Foundation or a Frontier Yet to Be Conquered? [PDF]
Int J Mol SciNappi F.
europepmc +1 more source
Regulation of Cardiac MicroRNAs by Cardiac MicroRNAs [PDF]
Circulation Research, 2013 Rationale: MicroRNAs modestly suppress their direct mRNA targets, and these direct effects are amplified by modulation of gene transcription pathways. Consequently, indirect mRNA modulatory effects of microRNAs to increase or decrease mRNAs greatly outnumber direct target suppressions.
Scot Matkovich
exaly +3 more sources
Annual Review of Pathology: Mechanisms of Disease, 2014 MicroRNAs (miRNAs) are small noncoding RNAs that typically inhibit the translation and stability of messenger RNAs (mRNAs), controlling genes involved in cellular processes such as inflammation, cell-cycle regulation, stress response, differentiation, apoptosis, and migration.
Gianpiero di Leva +2 more
exaly +3 more sources
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The Cancer Journal, 2008
MicroRNAs (miRNAs) are small, noncoding RNAs with regulatory functions, which play an important role in many human diseases, including cancer. An emerging number of studies show that miRNAs can act either as oncogenes or as tumor suppressor genes or sometimes as both. Germline, somatic mutations and polymorphisms can contribute to cancer predisposition.
Muller, Fabbri +2 more
openaire +2 more sources
MicroRNAs (miRNAs) are small, noncoding RNAs with regulatory functions, which play an important role in many human diseases, including cancer. An emerging number of studies show that miRNAs can act either as oncogenes or as tumor suppressor genes or sometimes as both. Germline, somatic mutations and polymorphisms can contribute to cancer predisposition.
Muller, Fabbri +2 more
openaire +2 more sources
MicroRNAs Regulating MicroRNAs in Cancer
Trends in Cancer, 2018MicroRNAs (miRNA) are capable of self-regulation, termed miRNA to miRNA interaction. Very little is known about these interactions and their impact on the cellular milieu. We discuss known miRNA to miRNA interactions, potential mechanisms, and their role in cancer.
Meredith, Hill, Nham, Tran
openaire +2 more sources
Participation of microRNAs in human interactome: extraction of microRNA–microRNA regulations
Molecular BioSystems, 2011Abstract To date, a significant amount of research has been conducted for computational modeling of the microRNA(miRNA)-targetgene interactions and inferring different kinds of biologically relevant association from their variable expressions, available from microarray experiments.
Debarka, Sengupta +1 more
openaire +2 more sources
2012
MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based on sequence complementarity between the miRNA and its targeted mRNA. Different names have been used to describe various types of miRNA. During evolution, RNA retroviruses or transgenes invaded the
Shao-Yao, Ying +2 more
openaire +3 more sources
MicroRNAs (miRNAs), widely distributed, small regulatory RNA genes, target both messenger RNA (mRNA) degradation and suppression of protein translation based on sequence complementarity between the miRNA and its targeted mRNA. Different names have been used to describe various types of miRNA. During evolution, RNA retroviruses or transgenes invaded the
Shao-Yao, Ying +2 more
openaire +3 more sources