Results 311 to 320 of about 398,176 (385)

ONO‐4578 Plus Nivolumab in Unresectable Advanced or Recurrent Gastric or Gastroesophageal Junction Cancer

Cancer Science, EarlyView.
The limited efficacy of current immune checkpoint inhibitors requires new approaches to overcome immunosuppression. In this phase 1 study, ONO‐4578 plus nivolumab showed a manageable safety profile, signs of antitumor activity, and immune activation, providing reference for further studies evaluating the clinical benefit of ONO‐4578 and nivolumab in ...
Akihito Kawazoe, Kensei Yamaguchi, Tetsuya Hamaguchi, Yukiya Narita, Shogen Boku, Takashi Oshima, Hiroki Hara, Yasuo Hamamoto, Kenji Ishido, Taito Esaki, Hisashi Hosaka, Hirofumi Yasui, Keisuke Koeda, Tomohiro Nishina, Yasushi Tsuji, Takeo Fukagawa, Masahiro Goto, Eiji Oki, Naotoshi Sugimoto, Hiroshi Matsuoka, Fumiharu Yokoyama, Tomoko Yoshida, Kazuo Yoshida, Yoshiaki Oshima, Satoru Iwasa   +24 more
wiley   +1 more source

MSI expresso: a software for determining MSI status and detecting MSI-related transcription events from RNA sequencing data. [PDF]

Front Genet
Tubacher E, How-Kit A, Sahbatou M, Duval A, Renault V, Deleuze JF.   +5 more
europepmc   +1 more source

Real‐World Comparison of Gene‐Matched vs. Non‐Gene‐Matched Therapy Outcomes Using Integrated Genomic and Clinical Data

Cancer Science, EarlyView.
We successfully integrated the C‐CAT repository and QI datasets to compare real‐world outcomes of gene‐matched therapy and non‐gene‐matched therapy, showing no significant difference in 2‐year overall survival between the groups. Potential reasons for this discrepancy from previous trials include differences in cancer types, comprehensive genomic ...
Taisuke Ishii, Takashi Kohno, Takashi Yugawa, Tatsuya Suzuki, Takafumi Koyama, Takahiro Higashi, Hiroyuki Mano, Yusuke Okuma   +7 more
wiley   +1 more source

Immune Checkpoint Inhibitors for Metastatic Colorectal Cancer: A Systematic Review. [PDF]

Cancers (Basel)
Gilson A, Tan V, Koessler T, Meyer J, Meurette G, Liot É, Ris F, Delaune V.   +7 more
europepmc   +1 more source

Correction to “Multi‐sequence MRI‐based clinical‐radiomics models for the preoperative prediction of microsatellite instability‐high status in endometrial cancer”

Precision Radiation Oncology, EarlyView.
wiley   +1 more source

Clinical Application of In‐House Comprehensive Genomic Profiling for Thoracic Cancer: Insights From a Japanese Hospital

Cancer Science, EarlyView.
We clarified the utility and challenges of in‐house comprehensive genomic profiling (CGP) testing in lung cancer care. ABSTRACT Comprehensive genomic profiling (CGP) is useful for optimizing targeted therapy and immunotherapy strategies for thoracic malignancies. This study aimed to evaluate the clinical utility and diagnostic complementarity of the in‐
Hatsuyo Takaoka, Hideki Terai, Kohei Nakamura, Takaaki Mizuno, Ryutaro Kawano, Katsura Emoto, Yutaka Kurebayashi, Nao Takada, Kenta Hamabe, Kazuhito Horie, Akihiko Ogata, Katsuhito Kinoshita, Lisa Shigematsu, Fumimaro Ito, Masahiko Okada, Takahiro Fukushima, Shigenari Nukaga, Testuo Tani, Keiko Ohgino, Kaoru Kaseda, Shinnosuke Ikemura, Hiroyuki Yasuda, Keisuke Asakura, Hajime Okita, Hiroshi Nishihara, Koichi Fukunaga   +25 more
wiley   +1 more source

Neoadjuvant Therapy in Locally Advanced Colon Cancer: A Case for Selective Adoption in pMMR and Transformation in dMMR

ANZ Journal of Surgery, EarlyView.
Rathin Gosavi, T. C. Nguyen, William Teoh, Satish Warrier, Alexander Heriot, Vignesh Narasimhan   +5 more
wiley   +1 more source

PMS2 c.2117del (p.Lys706Serfs*19) is the Most Frequent Cancer‐Associated Founder Pathogenic Variant in the French‐Canadian Population of Quebec, Canada

Clinical Genetics, EarlyView.
Using haplotype analysis, we characterized PMS2 c.2117del, identified in 22 families, as a founder variant in the French‐Canadian population of Quebec. It is the most frequent cancer‐associated founder variant in French‐Canadians, with over‐representation in five regions of Quebec. The variant contributed to colorectal and endometrial cancer incidence.
Anne‐Laure Chong, Alejandro Mejia‐Garcia, Supriya Behl, Zaki El Haffaf, Sébastien Chénier, Bruno Maranda, Valérie Désilets, Sébastien Lévesque, Lysanne Castonguay, Anne‐Marie Mes‐Masson, Sylvie Giroux, François Rousseau, Nancy Hamel, George Chong, Simon Gravel, William D. Foulkes   +15 more
wiley   +1 more source

Challenges and Pitfalls in Diagnosing Twins With Discordant BWS Phenotype

Clinical Genetics, EarlyView.
Accurately diagnosing Beckwith–Wiedemann syndrome (BWS) in twins with discordant phenotypes is essential for personalized oncological monitoring and management. It is advisable to test both twins, even without phenotypic expression, and incorporate prenatal factors like assisted reproduction technologies and twin pregnancies into the diagnostic BWS ...
Iacopo Bellani, Valentina Trevisan, Germana Viscogliosi, Maria Grazia Pomponi, Pietro Chiurazzi, Alessandro Mussa, Giuseppe Zampino, Maurizio Genuardi, Chiara Leoni   +8 more
wiley   +1 more source

Genetic Conservation and Population Management of Non-Human Primates: Parentage Determination Using Seven Microsatellite-Based Multiplexes. [PDF]

Ecol Evol
de Groot NG, de Vos-Rouweler AJM, Heijmans CMC, Louwerse A, Massen JJM, Langermans JAM, Bontrop RE, Bruijnesteijn J.   +7 more
europepmc   +1 more source