Results 321 to 330 of about 402,376 (385)

DNA Methylation in Ovarian and Endometrial Cancers: Predictive and Mechanistic Roles in PARP Inhibitor and ICI Response

Cancer Science, EarlyView.
Cancer treatment is shifting from an organ‐based framework to one driven by biological phenotypes, and DNA methylation is increasingly recognized as an important factor that governs tumor behavior beyond genetic mutations. In gynecologic cancers, BRCA1 and MLH1 promoter methylation–associated homologous recombination deficiency and mismatch repair ...
Shuhei Kitamura, Ayumi Taguchi, Kana Tamai, Yoko Yamamoto, Anh Quynh Duong, Daisuke Yoshimoto, Ayako Mori, Aya Ishizaka, Saki Tsuchimochi, Kenbun Sone, Masahito Kawazu, Katsutoshi Oda, Yasushi Hirota   +12 more
wiley   +1 more source

Additional Complexity in Historic and Contemporary Gene Flow Among Hoary, Vancouver Island, and Olympic Marmots Revealed by Microsatellites and Ultraconserved Elements. [PDF]

Ecol Evol
Hamilton NM, Kerhoulas NJ, Everson KM, Gunderson AM, Olson LE.   +4 more
europepmc   +1 more source

Activation of cGAS‐STING Pathway by DAI‐Triggered Ferroptosis in CRC Cells Reprograms TAMs Balance to Promote Anti‐Tumor Immunity

Cancer Science, EarlyView.
Our study identified and preliminarily elucidated the ferroptosis‐induced cGAS‐STING‐mediated anti‐tumor pathway triggered by DAI in colorectal cancer cells, providing new insight into the role of PCD in anti‐tumor immunotherapy and screening out potential targets for the treatment of colorectal cancer.
Pengrui Cheng, Que Yang, Xiao Zhang, Qiang Wang, Bingzheng Zhong   +4 more
wiley   +1 more source

Genetic analysis of the Siberian flying squirrel population in the northern Changbai Mountains, Northeast China: Insights into population status and conservation. [PDF]

Open Life Sci
Tian X, Shi L, Bai X, Wang Z.
europepmc   +1 more source

PMS2 c.2117del (p.Lys706Serfs*19) is the Most Frequent Cancer‐Associated Founder Pathogenic Variant in the French‐Canadian Population of Quebec, Canada

Clinical Genetics, EarlyView.
Using haplotype analysis, we characterized PMS2 c.2117del, identified in 22 families, as a founder variant in the French‐Canadian population of Quebec. It is the most frequent cancer‐associated founder variant in French‐Canadians, with over‐representation in five regions of Quebec. The variant contributed to colorectal and endometrial cancer incidence.
Anne‐Laure Chong, Alejandro Mejia‐Garcia, Supriya Behl, Zaki El Haffaf, Sébastien Chénier, Bruno Maranda, Valérie Désilets, Sébastien Lévesque, Lysanne Castonguay, Anne‐Marie Mes‐Masson, Sylvie Giroux, François Rousseau, Nancy Hamel, George Chong, Simon Gravel, William D. Foulkes   +15 more
wiley   +1 more source

Genetic diversity analysis of four Parabramis pekinensis populations based on microsatellite markers. [PDF]

Sci Rep
Liu Y, Yan C, Li H, Jin X, Liu P, Chen W, Liu H, Zhang Y, Liu J.   +8 more
europepmc   +1 more source

Use of DNA markers (AFLP) for genetically improving the productivity, palatability, sporability and dry matter content of tubers of greater yam. Final report [PDF]

, 2010
Abraham, K., Arnau, Gemma
core  

Neoadjuvant Therapy in Locally Advanced Colon Cancer: A Case for Selective Adoption in pMMR and Transformation in dMMR

ANZ Journal of Surgery, EarlyView.
Rathin Gosavi, T. C. Nguyen, William Teoh, Satish Warrier, Alexander Heriot, Vignesh Narasimhan   +5 more
wiley   +1 more source

Missense Variants in the Second Transmembrane Domain of TMEM17 Disrupt Its Stability and Function and Lead to a Wide Phenotypic Spectrum of Ciliopathies

Clinical Genetics, EarlyView.
Missense variants in TMEM17 disrupt its localization and function at the ciliary transition zone, leading to a wide range of ciliopathy phenotypes, from OFD6 and Joubert syndromes to Meckel syndrome. ABSTRACT Ciliopathies are rare genetic disorders characterized by significant genetic and phenotypic variability.
Lucile Boutaud, Chunmei Li, Candice Moncler, Laure Verlin, Meriem Garfa‐Traoré, Nicolas Bourgon, Dhruvin Akbari, Jeanne Porée, Valentina Serpieri, Marine Panza, Lynda Haddad, Patrick Nitschké, Jacqueline Aziza, Cristina Matt, Enza Maria Valente, Patricia Gargallo, Charlotte Dubucs, Tania Attié‐Bitach, Michel R. Leroux, Sophie Thomas   +19 more
wiley   +1 more source

Comprehensive Whole-Genome Survey and Analysis of the Naozhou Stock of Large Yellow Croakers (<i>Larimichthys crocea)</i>. [PDF]

Animals (Basel)
Wang HJ, Huang SP, Amenyogbe E, Liu Y, Jin JH, Lu Y, Boateng CN, Wang ZL, Huang JS.   +8 more
europepmc   +1 more source