Results 331 to 340 of about 402,376 (385)

Blurring the Lines: Co‐Occurrence of MSH6 Variant and MLH1 Constitutional Epimutation in a Young Colorectal Cancer Patient

Clinical Genetics, EarlyView.
We report a unique case of early‐onset colorectal cancer with both a germline MSH6 variant and constitutional mosaic MLH1 epimutation, revealing a possible digenic mechanism underlying Lynch syndrome. This case highlights the diagnostic complexity of mismatch repair deficiency and the value of integrative tumor–germline molecular profiling.
Aasem Abu Shtaya, Yarin Hadid, Ahmad Mahamid, Debora Kidron, Naama Halpern, Adel Shalata, Zohar Levi, Yael Goldberg   +7 more
wiley   +1 more source

Emergency Colectomy for Obstruction in Microsatellite Instability Colonic Cancer: A Complete Response Following Neoadjuvant Immunotherapy. [PDF]

Cureus
Mohamed L, Alzaz L, Dounya D, Ouazni M, Soufi M.   +4 more
europepmc   +1 more source

Genetic origins and climate‐induced erosion in economically important Asian walnuts

Conservation Biology, EarlyView.
Abstract The global climate is undergoing unprecedented changes, posing significant threats to species persistence. However, the spatiotemporal impacts on genetic diversity remain poorly understood, hindering species conservation and management. Walnuts, generally referred to as Juglans regia and J. sigillata, are economically vital in Asia, but little
Peng‐Zhen Fan, Guang‐Fu Zhu, Moses C. Wambulwa, Richard I. Milne, Zeng‐Yuan Wu, Ya‐Huang Luo, Robabeh Shahi Shavvon, Alistair S. Jump, Debabrata Maity, Lian‐Ming Gao, Hai‐Ling Qi, Hong‐Yu Wu, Xing Kong, Raees Khan, Li‐Jun Yan, Yerlan Turuspekov, De‐Zhu Li, Jie Liu   +17 more
wiley   +1 more source

Overestimation of clinical N-staging in microsatellite instable gastric cancers is associated with VEGF-C signaling and CD8+ T-cell dynamics. [PDF]

Oncologist
Tsai CY, Tai TS, Huang SC, Chen TH, Hsu JT, Yeh CN, Lai YC, Lin G, Yeh TS.   +8 more
europepmc   +1 more source

Genome‐Wide Screening in Haploid Stem Cells Reveals Synthetic Lethality Targeting MLH1 and TP53 Deficient Tumours

Cell Proliferation, EarlyView.
To identify genetic events that can lead to tumour death once either MLH1 or TP53 is mutated, a genome‐wide genetic screening was performed, uncovering a list of putative hits. Synthetic lethal interactions were validated either genetically or chemically by using small molecules that inhibit these genes either in vitro and in vivo.
Rivki Cashman, Guy Haim‐Abadi, Elyad Lezmi, Hagit Philip, Jonathan Nissenbaum, Ruth Viner‐Breuer, Chen Kozulin, Tamar Golan‐Lev, Aseel Gadban, Shiri Spinner‐Potesky, Ofra Yanuka, Oded Kopper, Nissim Benvenisty   +12 more
wiley   +1 more source

Elucidating the Role of <i>KRAS</i>, <i>NRAS</i>, and <i>BRAF</i> Mutations and Microsatellite Instability in Colorectal Cancer via Next-Generation Sequencing. [PDF]

Cancers (Basel)
Rodríguez MR, Biedma BA, Rodríguez Pérez I, Romeo JA.   +3 more
europepmc   +1 more source

Deciphering the Immunomodulatory Function of GSN+ Inflammatory Cancer‐Associated Fibroblasts in Renal Cell Carcinoma Immunotherapy: Insights From Pan‐Cancer Single‐Cell Landscape and Spatial Transcriptomics Analysis

Cell Proliferation, EarlyView.
Pan‐cancer scRNA‐seq and ST‐seq analyses identify GSN+ inflammatory cancer‐associated fibroblasts (CAFs) and their spatial distribution in immune checkpoint inhibitor (ICI) therapy. The Caf.Sig model accurately predicts ICI response across cancers using CAF gene signatures and machine learning.
Shan Li, Xinwei Zhou, Haoqian Feng, Kangbo Huang, Minyu Chen, Mingjie Lin, Hansen Lin, Zebing Deng, Yuhang Chen, Wuyuan Liao, Zhengkun Zhang, Jinwei Chen, Bohong Guan, Tian Su, Zihao Feng, Guannan Shu, Anze Yu, Yihui Pan, Liangmin Fu   +18 more
wiley   +1 more source

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Of Microbes and Microsatellites

Cancer Immunology Research, 2018
Abstract A ubiquitous oral cavity microbe, Fusobacterium nucleatum, is increasingly being implicated in colorectal cancer pathogenesis. An article in this issue elucidates the differential association of F. nucleatum with tumor-infiltrating lymphocytes depending on microsatellite instability status.
Alan P. Venook, Chloe E. Atreya
openaire   +2 more sources