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Trends in Ecology & Evolution, 1993
Many evolutionary studies, particularly kinship studies, have been limited by the availability of segregating genetic marker loci. Microsatellites promise to alleviate these problems. Microsatellite loci are segments of DNA with very short sequence motifs repeated in tandem; their often numerous alleles differ in the number of these repeat units.
Colin R. Hughes +2 more
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Many evolutionary studies, particularly kinship studies, have been limited by the availability of segregating genetic marker loci. Microsatellites promise to alleviate these problems. Microsatellite loci are segments of DNA with very short sequence motifs repeated in tandem; their often numerous alleles differ in the number of these repeat units.
Colin R. Hughes +2 more
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Microsatellites for Microbiologists
2012Microsatellites are repeating sequences of 2-6base pairs of DNA. Currently, they are used as molecular markers in many organisms, specifically in genetic studies analyzing kinship and population structure. In addition, they can be used to study gene duplication and/or deletion.
Lucinda A. Scriven +3 more
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A new bovine dinucleotide repeat microsatellite: microsatellite INRA 18
Animal Genetics, 1993An Anonymous clone containing a (TG)11 Microsatellites was isolated from a bovine genomic Sau3A size selected (approx.500pb) pGEM-4-Z library by hybridization to poly (dC-dT). Primers for polymerase chai reaction (PCR) were designed to amplify the region containing this microsatellite.
Moazami-Goudarzi, Katayoun +3 more
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Microsatellites for ecologists: a practical guide to using and evaluating microsatellite markers.
Ecology Letters, 2006AbstractRecent improvements in genetic analysis and genotyping methods have resulted in a rapid expansion of the power of molecular markers to address ecological questions. Microsatellites have emerged as the most popular and versatile marker type for ecological applications.
K. Selkoe, R. Toonen
semanticscholar +4 more sources
Mutational Dynamics of Microsatellites
Molecular Biotechnology, 2009Microsatellites are a ubiquitous class of simple repetitive DNA sequences, which are widespread in both eukaryotic and prokaryotic genomes. The use of microsatellites as polymorphic DNA markers has considerably increased both in the number of studies and in the number of organisms, primarily for genetic mapping, studying genomic instability in cancer ...
Francisco Fuentes, Atul Bhargava
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2013
Microsatellites have been utilized for decades for genotyping individuals in various types of research. Automated scoring of microsatellite loci has allowed for rapid interpretation of large datasets. Although the use of software produces an automated process to score or genotype samples, several sources of error have to be taken into account to ...
Flores-Renteria, Lluvia (R17984) +1 more
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Microsatellites have been utilized for decades for genotyping individuals in various types of research. Automated scoring of microsatellite loci has allowed for rapid interpretation of large datasets. Although the use of software produces an automated process to score or genotype samples, several sources of error have to be taken into account to ...
Flores-Renteria, Lluvia (R17984) +1 more
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Setting microsatellites free [PDF]
Nature Medicine, 1996 Altered microsatellite DNA in the blood of cancer patients may provide a novel method for tumor detection (pages 1033-1037).
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Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Microsatellite instability: an update
Archives of Toxicology, 2015Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Kohzoh Imai, Hiroyuki Yamamoto
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Microsatellite Instability Testing
2003Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Yann Parc, Kevin C. Halling
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