Results 351 to 360 of about 398,176 (385)
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, 2003
In molecular ecology the analysis of large microsatellite data sets is becoming increasingly popular. Here we introduce a new software tool, which is specifically designed to facilitate the analysis of large microsatellite data sets.
D. Dieringer, C. Schlötterer
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In molecular ecology the analysis of large microsatellite data sets is becoming increasingly popular. Here we introduce a new software tool, which is specifically designed to facilitate the analysis of large microsatellite data sets.
D. Dieringer, C. Schlötterer
semanticscholar +1 more source
Microsatellite instability: an update
Archives of Toxicology, 2015Deficient DNA mismatch repair (MMR) results in a strong mutator phenotype known as microsatellite instability (MSI), which is a hallmark of Lynch syndrome-associated cancers. MSI is characterized by length alterations within simple repeated sequences that are called microsatellites.
Kohzoh Imai, Hiroyuki Yamamoto
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Cytogenetic and Genome Research, 2001
Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Unlike aneuploidy, considered to be the cardinal feature of malignant tumors ever since the chromosomal analysis of neoplastic cells became technically feasible, a second pathway toward malignancy has emerged over the past decade that is not characterized by gross aneuploidy but, instead, by inactivation of the DNA mismatch repair system, leading to a ...
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Microsatellite Instability Testing
2003Microsatellites are tandem repeats of simple sequences that occur abundantly and are randomly interspersed throughout the human genome. They typically consist of 10-50 copies of 1-6 bp motifs, and are characterized by a high degree of polymorphism. Despite the variability observed among individuals, microsatellite are replicated faithfully at each cell
Yann Parc, Kevin C. Halling
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Microsatellites: Evolution and Contribution
2013Microsatellites are codominant molecular genetic markers, which are universally dispersed within genomes. These markers are highly popular because of their high level of polymorphism, relatively small size, and rapid detection protocols. They are widely used in a variety of fundamental and applied fields of biological sciences for plants and animal ...
Athanasios Tsaftaris +2 more
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Journal of Computational Biology, 2006
Genotype calling procedures vary from laboratory to laboratory for many microsatellite markers. Even within the same laboratory, application of different experimental protocols often leads to ambiguities. The impact of these ambiguities ranges from irksome to devastating.
Kenneth Lange +3 more
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Genotype calling procedures vary from laboratory to laboratory for many microsatellite markers. Even within the same laboratory, application of different experimental protocols often leads to ambiguities. The impact of these ambiguities ranges from irksome to devastating.
Kenneth Lange +3 more
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Cancer and forensic microsatellites
Forensic Science, Medicine, and Pathology, 2008Although not directly related, circumstances do occur in forensic investigations whereby cancer studies and forensic science cross paths. This review takes a look at the circumstances under which this may occur, and investigates some potential problems that can arise when tumor tissue is submitted for DNA profile analysis.
Karen Page, Eleanor A. M. Graham
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Detection of Microsatellite Instability [PDF]
, 2003 In 1993, three groups independently discovered that the lengths of microsatellites in tumors could vary from the normally constant pattern defined at birth (5-5) (see review in ref. 4). This discovery has been designated either microsatellite instability (MSI) or replication errors (RER).
James R. Eshleman +2 more
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Science immunology, 2019
VEGF-A drives T cell exhaustion via TOX-dependent transcriptional programming in microsatellite stable colorectal cancers. Trawling for drivers of T cell exhaustion Although checkpoint blockade has markedly changed the landscape of cancer therapeutics ...
C. Kim +24 more
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VEGF-A drives T cell exhaustion via TOX-dependent transcriptional programming in microsatellite stable colorectal cancers. Trawling for drivers of T cell exhaustion Although checkpoint blockade has markedly changed the landscape of cancer therapeutics ...
C. Kim +24 more
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Microsatellites: consensus and controversy
Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2000Microsatellite DNA loci have recently been adopted for many biological applications. Comparative studies across a wide range of species has revealed many details of their mutational properties and evolutionary life cycles. Experience shows that a full understanding of these processes is essential to ensure the effective use of microsatellites as ...
Elizabeth S. Macavoy +1 more
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