Results 71 to 80 of about 140,760 (298)

Genetic Diversity of Helmeted Guineafowl (Numida meleagris) Based on Microsatellite Analysis

The Journal of Poultry Science, 2010
Characterization of the genetic diversity of indigenous animal populations is a prerequisite for providing needed information for the conservation of useful genotypes against future uncertainties in the face of daunting global challenges such as climate ...
Boniface B. Kayang, Issaka Youssao, Eiji Inoue, Augustine Naazie, Hideaki Abe, Shin'ichi Ito, Miho Inoue-Murayama   +6 more
doaj   +1 more source

Advances in Medical Devices for Augmented Acupuncture Therapy

Advanced Science, EarlyView.
Traditional acupuncture therapy faces several challenges in clinical applications, such as complex operation procedures and prolonged therapeutic periods. By incorporating physical stimulations and drug delivery technologies, engineered acupuncture needles (EANs) can enhance therapeutic efficacy, improve patient compliance, as well as mitigate ...
Ruisi Cai, Chenyi Yu, Xinyi Luo, Ningyu Xu, Jicheng Yu, Xiao Ye, Yuqi Zhang, Zhen Gu   +7 more
wiley   +1 more source

Genetic Characterization of Taiwan Commercial Native Chickens Ascertained by Microsatellite Markers

The Journal of Poultry Science, 2013
Taiwan commercial native chickens have played a vital role in the domestic market due to Taiwanese traditional cooking style and culture. This study investigated the genetic characterization and population structure of 10 Taiwan commercial native ...
Manh-Hung Pham, Wei-Hua Chang, Cécile Berthouly-Salazar, Der-Yuh Lin, Sukanya Yungrahang, Chien-Chan Wang, Yen-Pai Lee, Michèle Tixier-Boichard, Chih-Feng Chen   +8 more
doaj   +1 more source

The Role of CAF‐derived Vitronectin in Promoting Colorectal Cancer Progression and Immunosuppression

Advanced Science, EarlyView.
Cancer‐associated fibroblast (CAF)‐derived VTN upregulates SLC6A8 expression in colorectal cancer (CRC) cells and macrophages through enhanced FAK phosphorylation. This modulation significantly increases the cellular uptake of creatine and ATP, promoting cancer progression and macrophage polarization.
Jiahua Yu, Mengxi Xiu, Shijun Yu, Zhiqin Chen, Yandong Li, Yong Gao   +5 more
wiley   +1 more source

Time-Dependent Changes in the Genetic Diversity and Structure of the Onagadori Breed of Chickens Based on Microsatellite DNA Polymorphisms

The Journal of Poultry Science, 2014
To conserve the Tosa-no-Onagadori (briefly Onagadori), one of the native Japanese chicken breeds designated as a Special National Natural Treasure of Japan, time-dependent changes in genetic diversity and structure were analyzed based on 20 ...
Takao Oka, Ryo Tadano, Tatsuhiko Goto, Jun-ichi Shiraishi, Sayed A.M. Osman, Naohiro Nagasaka, Takashi Bungo, Teruo Maeda, Masahide Nishibori, Tetsuya Umino, Masaoki Tsudzuki   +10 more
doaj   +1 more source

Manipulating Unisexual–Sexual Reproduction Transition to Engineer Genome‐Reconstructed Polyploids

Advanced Science, EarlyView.
This study developed an efficient approach to generate genome‐reconstructed polyploids involving unisexual gynogenetic Carassius gibelio, sexual C. auratus, and sexual C. cuvieri. The selected superior clone inherited gynogenesis ability of C. gibelio and herpesvirus resistance of wild C.
Meng Lu, Qin‐Can Zhang, Zi‐Yu Zhu, Yang Wang, Zhong‐Wei Wang, Xi‐Yin Li, Zhi Li, Xiao‐Juan Zhang, Li Zhou, Jian‐Fang Gui   +9 more
wiley   +1 more source

Radiomics‐Based Unsupervised Clustering Identifies Subtypes Associated With Prognosis and Immune Microenvironment in Clear Cell Renal Cell Carcinoma: A Multicenter Study

Advanced Science, EarlyView.
This study developed an unsupervised radiomics system integrating CT imaging and multi‐omics data to stratify clear cell renal cell carcinoma into two subtypes with distinct clinical outcomes. Cluster 1 showed lower recurrence risk and active immunity, while Cluster 2 exhibited higher recurrence risk, enriched VHL/KDM5C mutations, immunosuppressive ...
Yusheng Guo, Bingxin Gong, Yi Li, Jie Lou, Shuai Shan, Xiaodong Zhang, Qiang Lu, Dongyong Zhu, Qing Sun, Lianwei Miao, Yuanxi Li, Yu‐Dong Zhang, Wei Tan, Lian Yang, Chuansheng Zheng   +14 more
wiley   +1 more source

Comparative population genetic structure and demographic patterns of two killifish species (Aphanius baeticus and Aphanius iberus) at the Iberian Peninsula

Frontiers in Marine Science, 2015
The killifish, Aphanius baeticus and Aphanius iberus (Cyprinodontidae) are endemic species restricted to river basins on Spain’s southern Atlantic and Mediterranean coastline, respectively.
Elena G Gonzalez, Francisco Oliva-Paterna   +1 more
doaj   +1 more source

RUNX1/SLAMF3 Axis Drives Immunosuppression to Contribute to Colorectal Cancer Liver Metastasis by Blocking Phagocytosis and Depleting C1QC+ Tumor‐Associated Macrophages

Advanced Science, EarlyView.
This study identifies the RUNX1/SLAMF3 axis as a key driver of colorectal cancer liver metastasis (CRLM). SLAMF3 suppresses macrophage phagocytosis and depletes C1QC⁺ tumor‐associated macrophages, promoting an immunosuppressive microenvironment. Targeting this axis restores macrophage and CD8⁺ T cell activity and reduces metastasis.
Yinheng Luo, Xiaoli Jin, Lan Huang, Dejia Zeng, Nan Zhang, Shiyu Tang, Shu Luo, Samina Ejaz Syed, Ruiwu Dai, Qiu Li, Shufang Liang   +10 more
wiley   +1 more source

Personalized Neoantigen Vaccine plus Regorafenib Increases Rgs2⁺CD8⁺ T Cells Infiltration and Reprograms the Tumor Microenvironment in Microsatellite Stable Colorectal Cancer Liver Metastases

Advanced Science, EarlyView.
This study synthesized a personalized neoantigen vaccine (Neo‐CRCVAS) and combined it with regorafenib, termed RegoNeo. This combination therapy significantly enhanced antitumor efficacy and promoted long‐term tumor‐specific immune memory in microsatellite stable colorectal cancer liver metastasis (MSS‐CRLM) models by increasing neoantigen‐specific ...
Hengkai Chen, Bin Chen, Yuanfeng Yang, Shoufeng Li, Huajun Cai, Zhicheng Zhuang, Yong Wu, Yuan Gao, Yupeng Chen, Xing Liu, Guoxian Guan, Jinfu Zhuang   +11 more
wiley   +1 more source