Results 121 to 130 of about 50,169 (235)

Microsatellite Instability [PDF]

, 2020
openaire   +1 more source

Outcomes from the English National Lynch Syndrome transformation project

International Journal of Cancer, Volume 158, Issue 9, Page 2369-2379, 1 May 2026.
What's new? The elevated cancer risk conferred by Lynch syndrome can be mitigated through preventive interventions. However, Lynch syndrome often goes underdiagnosed. The National Lynch Syndrome Transformation Project in England aims to ensure that patients newly diagnosed with colorectal or endometrial cancer are offered testing for the syndrome ...
Kevin J. Monahan, Paul Fleming, Neil A. J. Ryan, Laura Monje‐Garcia, Ruth Armstrong, David N. Church, Jackie Cook, Fiona Lalloo, Sally Lane, Frank D. McDermott, Tracie Miles, Corinne Mallinson, Steven A. Hardy, Simone Gelinas, Francesca Faravelli, Frances Elmslie, Adam C. Shaw   +16 more
wiley   +1 more source

Natural History of Duodenal Adenoma: An 11‐year Follow‐up

DEN Open, Volume 6, Issue 1, April 2026.
ABSTRACT Early detection and treatment are essential to decrease the mortality rate of duodenal cancer (DC). However, the natural history of DC remains unclear. A 78‐year‐old woman underwent screening esophagogastroduodenoscopy (EGD) before surgery for advanced colon cancer.
Hikaru Kuribara, Naomi Kakushima, Hiroyuki Hisada, Yosuke Tsuji, Akihiko Ichida, Kiyoshi Hasegawa, Junichi Nawa, Tetsuo Ushiku, Mitsuhiro Fujishiro   +8 more
wiley   +1 more source

Low microsatellite instability revisited: a review. [PDF]

Virchows Arch
Grosser B, Kohlruss M, Keller G.
europepmc   +1 more source

Genomic and Immune Correlates of EZH2 Expression and Activity in Olfactory Neuroblastoma

Head &Neck, Volume 48, Issue 4, Page 932-940, April 2026.
ABSTRACT Purpose Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy with limited therapeutic options in the recurrent/metastatic setting; little is known regarding its responsiveness to immunotherapy. Inhibition of enhancer of zeste homolog 2 (EZH2) has been shown to improve T‐cell‐mediated killing and susceptibility to immune checkpoint ...
Elisabetta Xue, Tolulope Adeyelu, Harris Krause, Andrew Elliott, Ranee Mehra, Heloisa Soares, Emil Lou, Ari Vanderwalde, David Spetzler, Dara Bracken‐Clarke, Nyall R. London Jr., James L. Gulley, Charalampos S. Floudas   +12 more
wiley   +1 more source

Mismatch repair deficiency and microsatellite instability in adrenocortical carcinoma. [PDF]

ESMO Open
Altieri B, Kircher S, Herterich S, Jahn A, Teleanu MV, Lippert J, Landwehr LS, Kimpel O, Reuter M, Remde H, Stenzinger A, Glimm H, Bargou RC, Fröhling S, Ronchi CL, Appenzeller S, Fassnacht M, Kroiss M.   +17 more
europepmc   +1 more source

A Genome‐Wide Association Study of Colorectal Cancer Mortality Outcomes Among Individuals of African and Admixture Ancestry

Molecular Carcinogenesis, Volume 65, Issue 4, Page 422-433, April 2026.
ABSTRACT African Americans have the highest colorectal cancer (CRC) mortality rates in the United States. We performed the first genome‐wide association study (GWAS) of overall and CRC‐specific mortality among African Americans with incident CRC to identify genetic contributors to CRC outcomes.
Thomas Lawler, Jirong Long, Rene Welch, Irene Ong, Oluwatoyosi Ogunmuyiwa, Rida A. Khatri, Martha Shrubsole, Shaneda Warren Andersen   +7 more
wiley   +1 more source

Integrating artificial intelligence (AI) into colorectal cancer reporting

The Journal of Pathology, Volume 268, Issue 4, Page 367-382, April 2026.
Abstract Artificial intelligence (AI) and deep learning (DL) are transforming cancer research and clinical care, with histopathology playing a central role in this transformation. In colorectal cancer (CRC), the second leading cause of cancer mortality world‐wide, multimodal and vision‐language models (VLMs) hold particular promise for enhancing the ...
Konstantin Bräutigam, Ann‐Marie Baker, Viktor H Koelzer, Jakob N Kather, Trevor A Graham   +4 more
wiley   +1 more source

Intratumoral heterogeneity in microsatellite instability status at single-cell resolution. [PDF]

iScience
Anthony H, Seoighe C.
europepmc   +1 more source

The impact of the patient macroenvironment on molecular subgroups in endometrial cancer

Cancer, Volume 132, Issue 6, 15 March 2026.
Abstract More than half of endometrial cancer diagnoses can be attributed to obesity. A purely molecular classification in endometrial cancer hampers further understanding of the impact of patient macroenvironment as a major risk factor. The relationship between patient factors, such as age, body mass index (BMI), comorbidity, and ethnicity, and ...
Henrica M. J. Werner, Frederiek A. H. van Dijk, Stephanie W. Vrede, Anouk A. S. van den Bosch, Marike S. Lombaers, Jasmin Asberger, Jutta Huvila, Marc Snijders, Valeria Tubita, Gemma Mancebo Moreno, Xavier Matias‐Guiu, Petra Bretová, ENITEC Consortium, Vit Weinberger, Johanna M. A. Pijnenborg   +14 more
wiley   +1 more source